scholarly journals A histochemical study on condylar cartilage and glenoid fossa during mandibular advancement

2011 ◽  
Vol 81 (2) ◽  
pp. 270-276 ◽  
Author(s):  
Payam Owtad ◽  
Zoe Potres ◽  
Gang Shen ◽  
Peter Petocz ◽  
M. Ali Darendeliler
Keyword(s):  
Histochemical Study ◽  
Mandibular Advancement ◽  
Glenoid Fossa ◽  
Condylar Cartilage

scholarly journals PTHrP Regulates Chondrocyte Maturation in Condylar Cartilage

2003 ◽  
Vol 82 (8) ◽  
pp. 627-631 ◽  
Author(s):  
A.B.M. Rabie ◽  
G.H. Tang ◽  
H. Xiong ◽  
U. Hägg
Keyword(s):  
Cell Differentiation ◽  
Skeletal Development ◽  
Mesenchymal Cell ◽  
Cartilage Volume ◽  
Mandibular Advancement ◽  
Sprague Dawley ◽  
Condylar Cartilage ◽  
Experimental Animals ◽  
Chondrocyte Maturation ◽  
Pthrp Expression

PTHrP is a key factor regulating the pace of endochondral ossification during skeletal development. Mandibular advancement solicits a cascade of molecular responses in condylar cartilage. However, the pace of cellular maturation and its effects on condylar growth are still unknown. The purpose of this study was to evaluate the pattern of expression of PTHrP and correlate it to cellular dynamics of chondrocytes in condylar cartilage during natural growth and mandibular advancement. We fitted 35-day-old Sprague-Dawley rats with functional appliances. Experimental animals with matched controls were labeled with bromodeoxyuridine 3 days before their death, so that mesenchymal cell differentiation could be traced. Mandibular advancement increased the number of differentiated chondroblasts and subsequently increased the cartilage volume. Higher levels of PTHrP expression in experimental animals coincided with the slowing of chondrocyte hypertrophy. Thus, mandibular advancement promoted mesenchymal cell differentiation and triggered PTHrP expression, which retarded their further maturation to allow for more growth.

scholarly journals Runx2 Regulates Endochondral Ossification in Condyle during Mandibular Advancement

2005 ◽  
Vol 84 (2) ◽  
pp. 166-171 ◽  
Author(s):  
G.H. Tang ◽  
A.B.M. Rabie
Keyword(s):  
Endochondral Ossification ◽  
Mandibular Condyle ◽  
Mandibular Advancement ◽  
New Bone Formation ◽  
Sprague Dawley ◽  
Condylar Cartilage ◽  
Runx2 Expression ◽  
Chondrocyte Maturation ◽  
Sprague Dawley Rats ◽  
Functional Appliances

Runx2 is a transcription factor prerequisite for chondrocyte maturation and osteoblast differentiation. We tested the hypothesis that Runx2 is responsible for signaling chondrocyte maturation and endochondral ossification in the condyle during mandibular advancement. Fifty 35-day-old Sprague-Dawley rats were fitted with functional appliances for 3, 7, 14, 21, and 30 days. Experimental animals with 50 matched controls were labeled with bromodeoxyuridine for evaluation of the invasion of chondroclasts and osteoblasts into condylar cartilage. Mandibular advancement elicited Runx2 expression in condylar cartilage, and subsequently led to an expansion of type X collagen domain in the hypertrophic layer. Stronger Runx2 mRNA signals in subchondral bone corresponded with the increase in the recruitment of osteoblasts and chondroclasts, which preceded the increase of new bone formation in the condyle. Thus, Runx2 mediates chondrocyte terminal maturation and endochondral ossification in the mandibular condyle in response to mandibular advancement.

scholarly journals Indian Hedgehog: A Mechanotransduction Mediator in Condylar Cartilage

2004 ◽  
Vol 83 (5) ◽  
pp. 434-438 ◽  
Author(s):  
G.H. Tang ◽  
A.B.M. Rabie ◽  
U. Hägg
Keyword(s):  
Cellular Proliferation ◽  
Signal Transduction Pathway ◽  
Mesenchymal Cells ◽  
Turnover Time ◽  
Tissue Growth ◽  
Mandibular Advancement ◽  
Indian Hedgehog ◽  
Sprague Dawley ◽  
Condylar Cartilage ◽  
Mechanical Signals

Indian hedgehog (Ihh) is a critical mediator transducing mechanical signals to stimulate chondrocyte proliferation. To clarify the cellular signal transduction pathway that senses and converts mechanical signals into tissue growth in mandibular condyle, we evaluated Ihh expression and its relation to the kinetics of replicating mesenchymal cells in condylar cartilage during natural growth and mandibular advancement. Thirty-five-day-old Sprague-Dawley rats were fitted with functional appliances. Experimental animals with matched controls were doubly labeled with iododeoxyuridine and bromodeoxyuridine so that we could evaluate the cycles of the proliferative mesenchymal cells. Mandibular advancement triggered Ihh expression in condylar cartilage. A higher level of Ihh expression coincided with the increase of the replicating mesenchymal cells’ population and the shortening of the turnover time. These findings suggested that Ihh acts as a mediator of mechanotransduction that converts mechanical signals resulting from anterior mandibular displacement to stimulate cellular proliferation in condylar cartilage.

Osteogenesis in the glenoid fossa in response to mandibular advancement

2001 ◽  
Vol 119 (4) ◽  
pp. 390-400 ◽  
Author(s):  
A.Bakr M. Rabie ◽  
Zhihe Zhao ◽  
Gang Shen ◽  
E.Urban Hägg ◽  
Wayne Robinson
Keyword(s):  
Mandibular Advancement ◽  
Glenoid Fossa
Sign in / Sign up

Export Citation Format

Share Document