Hypoglycemia-Associated Autonomic Failure in Type 1 Diabetes: Beyond Hypoglycemia Unawareness

2021 ◽  
pp. cd210100
Author(s):  
Aristeidis Giannakopoulos ◽  
Alexandra Efthymiadou ◽  
Anastasia Chrysanthakopoulou ◽  
Dionisios Chrysis
Keyword(s):  
Type 1 Diabetes ◽  
Autonomic Failure ◽  
Hypoglycemia Unawareness

scholarly journals Differential Expression of Inflammatory Markers in Hypoglycemia Unawareness Associated with Type 1 Diabetes: A Case Report

2020 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Yousef Al Zoubi ◽  
Bashair M. Mussa ◽  
Ankita Srivastava ◽  
Abdul Khader Mohammed ◽  
Elamin Abdelgadir ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Case Report ◽  
Differential Expression ◽  
Insulin Pump ◽  
Mrna Level ◽  
Insulin Injection ◽  
Hypoglycemia Unawareness ◽  
Tnf Α ◽  
Ifn Γ

The recurrence of hypoglycemic episodes leads to attenuation of the normal counter-regulatory mechanisms that are controlled by the hypothalamus, which results in hypoglycemia unawareness (HU). In this case report, we described for the first time the differential expression of TNF-α, IL-1β, IL-6, and IFN-γ in a blood sample that was taken from a 27-year-old patient with type 1 diabetes mellitus (T1DM) who was diagnosed with HU. The anti-diabetic regimen is currently based on insulin injection, but the patient is planning to start the use of an insulin pump to have better control of glucose levels. Our results showed a trend toward an increase in the expression of IL-1β, IL-6, and IFN-γ in T1DM patient with HU. However, the mRNA level of TNF-α showed a significant decrease. These observations suggest that systemic inflammation could be an underlying cause of HU.

Hypoglycemia Unawareness and Type 1 Diabetes

2004 ◽  
Vol 97 (11) ◽  
pp. 1143-1144
Author(s):  
Steven V. Edelman ◽  
Candis M. Morello
Keyword(s):  
Type 1 Diabetes ◽  
Hypoglycemia Unawareness

The Arg16Gly variant of the ??2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus

2008 ◽  
Vol 18 (4) ◽  
pp. 369-372 ◽  
Author(s):  
Bas J. Schouwenberg ◽  
Bart A. Veldman ◽  
Wilko Spiering ◽  
Marieke J. Coenen ◽  
Barbara Franke ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Adrenergic Receptor ◽  
Hypoglycemia Unawareness

Abstract P011: Hypoglycemia Unawareness is Associated With Impaired Cognition Among Older Adults With Type 1 Diabetes: the Study of Longevity in Diabetes

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
Mary E Lacy ◽  
Paola Gilsanz ◽  
Michal Schnaider-Beeri ◽  
Andrew J Karter ◽  
Charles P Quesenberry ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Hypoglycemia Unawareness ◽  
Impaired Cognition

scholarly journals Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222771 ◽  
Author(s):  
Jan Benedikt Groener ◽  
Aikaterini Valkanou ◽  
Zoltan Kender ◽  
Jan Pfeiffenberger ◽  
Lars Kihm ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Hypoglycemia Unawareness
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