scholarly journals Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice: The Paradox in Transgenic Models

Diabetes ◽  
2008 ◽  
Vol 57 (7) ◽  
pp. 1861-1869 ◽  
Author(s):  
C.-J. Wang ◽  
F.-C. Chou ◽  
C.-H. Chu ◽  
J.-C. Wu ◽  
S.-H. Lin ◽  
...  
Keyword(s):  
Protective Role ◽  
Diabetic Mice ◽  
Transgenic Models ◽  
Nonobese Diabetic ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Nonobese Diabetic Mice

scholarly journals Correction: Autoimmunity during Thymectomy-Induced Lymphopenia: Role of Thymus Ablation and Initial Effector T Cell Activation Timing in Nonobese Diabetic Mice

2010 ◽  
Vol 185 (5) ◽  
pp. 3111-3111
Author(s):  
Marie-Claude Gagnerault ◽  
Olivia Lanvin ◽  
Virginie Pasquier ◽  
Corinne Garcia ◽  
Diane Damotte ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Diabetic Mice ◽  
Effector T Cell ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Autoimmunity during Thymectomy-Induced Lymphopenia: Role of Thymus Ablation and Initial Effector T Cell Activation Timing in Nonobese Diabetic Mice

2009 ◽  
Vol 183 (8) ◽  
pp. 4913-4920 ◽  
Author(s):  
Marie-Claude Gagnerault ◽  
Olivia Lanvin ◽  
Virginie Pasquier ◽  
Corinne Garcia ◽  
Diane Damotte ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Diabetic Mice ◽  
Effector T Cell ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Reversal of Spontaneous Autoimmune Insulitis in Nonobese Diabetic Mice by Soluble Lymphotoxin Receptor

2001 ◽  
Vol 193 (11) ◽  
pp. 1327-1332 ◽  
Author(s):  
Qiang Wu ◽  
Benoît Salomon ◽  
Min Chen ◽  
Yang Wang ◽  
Lisa M. Hoffman ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Critical Role ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Transfer Model ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Insulin Dependent ◽  
Nonobese Diabetic Mice

One striking feature of spontaneous autoimmune diabetes is the prototypic formation of lymphoid follicular structures within the pancreas. Lymphotoxin (LT) has been shown to play an important role in the formation of lymphoid follicles in the spleen. To explore the potential role of LT-mediated microenvironment in the pathogenesis of insulin-dependent diabetes mellitus (IDDM), an LTβ receptor–immunoglobulin fusion protein (LTβR–Ig) was administered to nonobese diabetic mice. Early treatment with LTβR–Ig prevented insulitis and IDDM, suggesting that LT plays a critical role in the insulitis development. LTβR–Ig treatment at a late stage of the disease also dramatically reversed insulitis and prevented diabetes. Moreover, LTβR–Ig treatment prevented the development of IDDM by diabetogenic T cells in an adoptive transfer model. Thus, LTβR–Ig can disassemble the well established lymphoid microenvironment in the islets, which is required for the development and progression of IDDM.

The role of cytokines during rejection of foetal pig and foetal mouse pancreas grafts in nonobese diabetic mice

1997 ◽  
Vol 5 (4) ◽  
pp. 307-314 ◽  
Author(s):  
Jiri Kovarik ◽  
Maria Koulmanda ◽  
Thomas E. Mandel
Keyword(s):  
Diabetic Mice ◽  
Mouse Pancreas ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice.

1994 ◽  
Vol 91 (26) ◽  
pp. 12604-12608 ◽  
Author(s):  
X. D. Yang ◽  
S. A. Michie ◽  
R. Tisch ◽  
N. Karin ◽  
L. Steinman ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Predominant Role ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Testing the Role of P2X7 Receptors in the Development of Type 1 Diabetes in Nonobese Diabetic Mice

2011 ◽  
Vol 186 (7) ◽  
pp. 4278-4284 ◽  
Author(s):  
Yi-Guang Chen ◽  
Felix Scheuplein ◽  
John P. Driver ◽  
Amanda A. Hewes ◽  
Peter C. Reifsnyder ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Mice ◽  
P2x7 Receptors ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

Correction: The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic Mice

2012 ◽  
Vol 188 (7) ◽  
pp. 3552-3552
Author(s):  
Changyun Hu ◽  
Wei Du ◽  
Xiaojun Zhang ◽  
F. Susan Wong ◽  
Li Wen
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice ◽  
Anti Cd20

The Role of Fas Ligand in the Development of Insulitis in Nonobese Diabetic Mice

Pancreas ◽  
1998 ◽  
Vol 16 (2) ◽  
pp. 154-159 ◽  
Author(s):  
S Sainio-Pöllänen ◽  
S Erkkilä ◽  
S Alanko ◽  
A Hänninen ◽  
P. Pöllänen ◽  
...  
Keyword(s):  
Fas Ligand ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals The Role of Gr1+ Cells after Anti-CD20 Treatment in Type 1 Diabetes in Nonobese Diabetic Mice

2011 ◽  
Vol 188 (1) ◽  
pp. 294-301 ◽  
Author(s):  
Changyun Hu ◽  
Wei Du ◽  
Xiaojun Zhang ◽  
F. Susan Wong ◽  
Li Wen
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice ◽  
Anti Cd20
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