scholarly journals Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study

Diabetes ◽  
2018 ◽  
Vol 67 (8) ◽  
pp. 1684-1696 ◽  
Author(s):  
Stephanie J. Loomis ◽  
Man Li ◽  
Nisa M. Maruthur ◽  
Abigail S. Baldridge ◽  
Kari E. North ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Glycated Albumin ◽  
Genome Wide Association ◽  
Atherosclerosis Risk In Communities ◽  
Genome Wide ◽  
Serum Fructosamine ◽  
Atherosclerosis Risk ◽  
Diagnosed Diabetes

scholarly journals An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript

2021 ◽  
Author(s):  
Fernando Riveros-Mckay ◽  
David Roberts ◽  
Emanuele Di Angelantonio ◽  
Bing Yu ◽  
Nicole Soranzo ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
European Ancestry ◽  
Diabetes Diagnosis ◽  
Atherosclerosis Risk In Communities ◽  
Functional Studies ◽  
Genome Wide ◽  
Novel Association ◽  
Localization Analysis

Fructosamine is a measure of short-term glycemic control, which has been suggested as a useful complement to glycated hemoglobin (HbA1c) for the diagnosis and monitoring of diabetes. To date, a single genome-wide association study (GWAS) including 8,951 US White and 2,712 US Black individuals without a diabetes diagnosis has been published. Results in Whites and Blacks yielded different association loci, near <i>RCN3</i> and <i>CNTN5</i>, respectively. Here we performed a GWAS on 20,731 European ancestry blood donors, and meta-analysed our results with previous data from US White participants from The Atherosclerosis Risk in Communities (ARIC) study (N<sub>meta</sub>=29,685). We identified a novel association near <i>GCK</i> (rs3757840, beta<sub>meta</sub>=0.0062, MAF=0.49, <i>p<sub>meta</sub></i>=3.66x10<sup>-08</sup>) and confirmed the association near <i>RCN3</i> (rs113886122, beta<sub>meta</sub>=0.0134, MAF=0.17, <i>p<sub>meta</sub></i>= 5.71x10<sup>-18</sup>). Co-localization analysis with whole blood eQTL data suggested <i>FCGRT</i> as the effector transcript at the <i>RCN3</i> locus. We further showed that fructosamine has low heritability (h2=7.7%), has no significant genetic correlation with HbA1c and other glycemic traits in individuals without a diabetes diagnosis (p>0.05), but has evidence of shared genetic etiology with some anthropometric traits (Bonferroni corrected p<0.0012). Our results broaden knowledge of the genetic architecture of fructosamine and prioritize <i>FCGRT </i>for downstream functional studies at<i> </i>the established <i>RCN3</i> locus.

scholarly journals An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript

2021 ◽  
Author(s):  
Fernando Riveros-Mckay ◽  
David Roberts ◽  
Emanuele Di Angelantonio ◽  
Bing Yu ◽  
Nicole Soranzo ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
European Ancestry ◽  
Diabetes Diagnosis ◽  
Atherosclerosis Risk In Communities ◽  
Functional Studies ◽  
Genome Wide ◽  
Novel Association ◽  
Localization Analysis

Fructosamine is a measure of short-term glycemic control, which has been suggested as a useful complement to glycated hemoglobin (HbA1c) for the diagnosis and monitoring of diabetes. To date, a single genome-wide association study (GWAS) including 8,951 US White and 2,712 US Black individuals without a diabetes diagnosis has been published. Results in Whites and Blacks yielded different association loci, near <i>RCN3</i> and <i>CNTN5</i>, respectively. Here we performed a GWAS on 20,731 European ancestry blood donors, and meta-analysed our results with previous data from US White participants from The Atherosclerosis Risk in Communities (ARIC) study (N<sub>meta</sub>=29,685). We identified a novel association near <i>GCK</i> (rs3757840, beta<sub>meta</sub>=0.0062, MAF=0.49, <i>p<sub>meta</sub></i>=3.66x10<sup>-08</sup>) and confirmed the association near <i>RCN3</i> (rs113886122, beta<sub>meta</sub>=0.0134, MAF=0.17, <i>p<sub>meta</sub></i>= 5.71x10<sup>-18</sup>). Co-localization analysis with whole blood eQTL data suggested <i>FCGRT</i> as the effector transcript at the <i>RCN3</i> locus. We further showed that fructosamine has low heritability (h2=7.7%), has no significant genetic correlation with HbA1c and other glycemic traits in individuals without a diabetes diagnosis (p>0.05), but has evidence of shared genetic etiology with some anthropometric traits (Bonferroni corrected p<0.0012). Our results broaden knowledge of the genetic architecture of fructosamine and prioritize <i>FCGRT </i>for downstream functional studies at<i> </i>the established <i>RCN3</i> locus.

Genome wide association study on memory in schizophrenia patients and unaffected probands

2009 ◽  
Vol 42 (05) ◽  
Author(s):  
B Konte ◽  
I Giegling ◽  
AM Hartmann ◽  
H Konnerth ◽  
P Muglia ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

Genome-wide association study meta-analysis identifies the SOAT1/AXDND1 locus to be associated with hip and forearm fracture risk

2013 ◽  
Author(s):  
Ulrika Pettersson-Kymmer ◽  
Andrea Lacroix ◽  
Joel Eriksson ◽  
Ulrica Bergstrom ◽  
Beatrice Melin ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Forearm Fracture ◽  
Genome Wide Association ◽  
Genome Wide

1701-P: Genome-Wide Association Study Identifies Novel Potential Associations with Birth Weight in a Southwestern American Indian Population

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1701-P
Author(s):  
LAUREN E. WEDEKIND ◽  
WEN-CHI HSUEH ◽  
SAYUKO KOBES ◽  
MUIDEEN T. OLAIYA ◽  
WILLIAM C. KNOWLER ◽  
...  
Keyword(s):  
Birth Weight ◽  
American Indian ◽  
Association Study ◽  
Indian Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
American Indian Population ◽  
Genome Wide
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