Genome-wide association study meta-analysis identifies the SOAT1/AXDND1 locus to be associated with hip and forearm fracture risk

2013 ◽  
Author(s):  
Ulrika Pettersson-Kymmer ◽  
Andrea Lacroix ◽  
Joel Eriksson ◽  
Ulrica Bergstrom ◽  
Beatrice Melin ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Forearm Fracture ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse

2021 ◽  
Author(s):  
Mengyao Yu ◽  
Sergiy Kyryachenko ◽  
Stephanie Debette ◽  
Philippe Amouyel ◽  
Jean-Jacques Schott ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cardiac Development ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Uk Biobank ◽  
Additional Risk ◽  
Genome Wide ◽  
The Uk

Background: Mitral valve prolapse (MVP) is a common cardiac valve disease, which affects 1 in 40 in the general population. Previous genome-wide association study have identified 6 risk loci for MVP. But these loci explained only partially the genetic risk for MVP. We aim to identify additional risk loci for MVP by adding data set from the UK Biobank. Methods: We reanalyzed 1007/479 cases from the MVP-France study, 1469/862 controls from the MVP-Nantes study for reimputation genotypes using HRC and TOPMed panels. We also incorporated 434 MVP cases and 4527 controls from the UK Biobank for discovery analyses. Genetic association was conducted using SNPTEST and meta-analyses using METAL. We used FUMA for post-genome-wide association study annotations and MAGMA for gene-based and gene-set analyses. Results: We found TOPMed imputation to perform better in terms of accuracy in the lower ranges of minor allele frequency below 0.1. Our updated meta-analysis included UK Biobank study for ≈8 million common single-nucleotide polymorphisms (minor allele frequency >0.01) and replicated the association on Chr2 as the top association signal near TNS1 . We identified an additional risk locus on Chr1 ( SYT2 ) and 2 suggestive risk loci on chr8 ( MSRA ) and chr19 ( FBXO46 ), all driven by common variants. Gene-based association using MAGMA revealed 6 risk genes for MVP with pronounced expression levels in cardiovascular tissues, especially the heart and globally part of enriched GO terms related to cardiac development. Conclusions: We report an updated meta-analysis genome-wide association study for MVP using dense imputation coverage and an improved case-control sample. We describe several loci and genes with MVP spanning biological mechanisms highly relevant to MVP, especially during valve and heart development.

scholarly journals Genome-Wide Association Study Meta-Analysis Reveals Transethnic Replication of Mean Arterial and Pulse Pressure Loci

Hypertension ◽  
2013 ◽  
Vol 62 (5) ◽  
pp. 853-859 ◽  
Author(s):  
Tanika N. Kelly ◽  
Fumihiko Takeuchi ◽  
Yasuharu Tabara ◽  
Todd L. Edwards ◽  
Young Jin Kim ◽  
...  
Keyword(s):  
Association Study ◽  
Pulse Pressure ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies

Placenta ◽  
2018 ◽  
Vol 66 ◽  
pp. 8-16 ◽  
Author(s):  
Tsegaselassie Workalemahu ◽  
Daniel A. Enquobahrie ◽  
Bizu Gelaye ◽  
Sixto E. Sanchez ◽  
Pedro J. Garcia ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Placental Abruption ◽  
Association Studies ◽  
Meta Analysis ◽  
Genetic Variations ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
A Genome

GENOME WIDE ASSOCIATION STUDY META-ANALYSIS OF HOMOARGININE USING THE HRC REFERENCE PANEL

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e94
Author(s):  
M. Kleber ◽  
L.P. Lyytikainen ◽  
G.E. Delgado ◽  
C. Drechsler ◽  
C. Wanner ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Reference Panel ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Melanie D. Napier ◽  
Nora Franceschini ◽  
Rahul Gondalia ◽  
James D. Stewart ◽  
Raúl Méndez-Giráldez ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women

Bone Reports ◽  
2016 ◽  
Vol 5 ◽  
pp. 233-242 ◽  
Author(s):  
Kira C. Taylor ◽  
Daniel S. Evans ◽  
Digna R. Velez Edwards ◽  
Todd L. Edwards ◽  
Tamar Sofer ◽  
...  
Keyword(s):  
African American ◽  
Association Study ◽  
African American Women ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
American Women ◽  
Clinical Fracture ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide association study of glioma and meta-analysis

2012 ◽  
Vol 131 (12) ◽  
pp. 1877-1888 ◽  
Author(s):  
Preetha Rajaraman ◽  
Beatrice S. Melin ◽  
Zhaoming Wang ◽  
Roberta McKean-Cowdin ◽  
Dominique S. Michaud ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide
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