scholarly journals Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice

Diabetes ◽  
2018 ◽  
Vol 67 (11) ◽  
pp. 2349-2360 ◽  
Author(s):  
Christopher S. Wilson ◽  
Preeti Chhabra ◽  
Andrew F. Marshall ◽  
Caleigh V. Morr ◽  
Blair T. Stocks ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Healthy Donor ◽  
B Lymphocyte ◽  
Nod Mice ◽  
Cell Generation

scholarly journals Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a β-cell neo-self-antigen in type 1 diabetes prone NOD mice

2010 ◽  
Vol 40 (12) ◽  
pp. 3413-3425 ◽  
Author(s):  
Selwyn Lewis Cox ◽  
Jessica Stolp ◽  
Nicole L. Hallahan ◽  
Jacqueline Counotte ◽  
Wenyu Zhang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
B Lymphocyte ◽  
Nod Mice ◽  
Β Cell ◽  
T Cell Help ◽  
Self Antigen

scholarly journals Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

PLoS Medicine ◽  
2016 ◽  
Vol 13 (10) ◽  
pp. e1002139 ◽  
Author(s):  
John A. Todd ◽  
Marina Evangelou ◽  
Antony J. Cutler ◽  
Marcin L. Pekalski ◽  
Neil M. Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
T Cell ◽  
Regulatory T Cell ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Dose Finding ◽  
Open Label ◽  
Cell Responses

scholarly journals T-Cell–Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities

Diabetes ◽  
2019 ◽  
Vol 68 (6) ◽  
pp. 1251-1266 ◽  
Author(s):  
Florian Wiede ◽  
Thomas C. Brodnicki ◽  
Pei Kee Goh ◽  
Yew A. Leong ◽  
Gareth W. Jones ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Nod Mice

scholarly journals Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability

Diabetologia ◽  
2020 ◽  
Vol 63 (5) ◽  
pp. 987-1001
Author(s):  
Jing Zhang ◽  
Longmin Chen ◽  
Faxi Wang ◽  
Yuan Zou ◽  
Jingyi Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Stability

scholarly journals Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”

2017 ◽  
Vol 214 (7) ◽  
pp. 2157-2159
Author(s):  
Carolin Daniel ◽  
Benno Weigmann ◽  
Harald von Boehmer
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Preventive Effect ◽  
Peptide Therapy ◽  
Cell Conversion

In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.

scholarly journals A Mimic of Viral Double-Stranded RNA Triggers Fulminant Type 1 Diabetes-like Syndrome in Regulatory T Cell-Deficient Autoimmune Diabetic Mouse

2011 ◽  
Vol 187 (10) ◽  
pp. 4947-4953 ◽  
Author(s):  
Ai Tada ◽  
Akira Shimada ◽  
Taketo Yamada ◽  
Yoichi Oikawa ◽  
Yoshifumi Yamada ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Diabetic Mouse ◽  
Fulminant Type 1 Diabetes ◽  
Double Stranded Rna ◽  
Fulminant Type

scholarly journals Deficiency in NOD Antigen-Presenting Cell Function May Be Responsible for Suboptimal CD4+CD25+ T-Cell-Mediated Regulation and Type 1 Diabetes Development in NOD Mice

Diabetes ◽  
2006 ◽  
Vol 55 (7) ◽  
pp. 2098-2105 ◽  
Author(s):  
P. Alard ◽  
J. N. Manirarora ◽  
S. A. Parnell ◽  
J. L. Hudkins ◽  
S. L. Clark ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cell Function ◽  
Nod Mice ◽  
Antigen Presenting Cell ◽  
Diabetes Development ◽  
Antigen Presenting

Treatment of type 1 diabetes by regulatory T‐cell infusion via regulating the expression of inflammatory cytokines

2019 ◽  
Vol 120 (12) ◽  
pp. 19338-19344 ◽  
Author(s):  
Guofeng Wang ◽  
Yongxin Yan ◽  
Ning Xu ◽  
Dong Yin ◽  
Yuan Hui
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Inflammatory Cytokines ◽  
Regulatory T Cell

Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes

Diabetologia ◽  
2014 ◽  
Vol 57 (7) ◽  
pp. 1428-1436 ◽  
Author(s):  
Michael S. Turner ◽  
Kumiko Isse ◽  
Douglas K. Fischer ◽  
Hēth R. Turnquist ◽  
Penelope A. Morel
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Signal Strength ◽  
Cell Populations

scholarly journals A Reg Family Protein Is Overexpressed in Islets From a Patient With New-Onset Type 1 Diabetes and Acts as T-Cell Autoantigen in NOD Mice

Diabetes ◽  
2002 ◽  
Vol 51 (2) ◽  
pp. 339-346 ◽  
Author(s):  
W. Gurr ◽  
R. Yavari ◽  
L. Wen ◽  
M. Shaw ◽  
C. Mora ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Nod Mice ◽  
Onset Type ◽  
Family Protein ◽  
New Onset
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