Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes

Diabetologia ◽  
2014 ◽  
Vol 57 (7) ◽  
pp. 1428-1436 ◽  
Author(s):  
Michael S. Turner ◽  
Kumiko Isse ◽  
Douglas K. Fischer ◽  
Hēth R. Turnquist ◽  
Penelope A. Morel
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Signal Strength ◽  
Cell Populations

scholarly journals Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

PLoS Medicine ◽  
2016 ◽  
Vol 13 (10) ◽  
pp. e1002139 ◽  
Author(s):  
John A. Todd ◽  
Marina Evangelou ◽  
Antony J. Cutler ◽  
Marcin L. Pekalski ◽  
Neil M. Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
T Cell ◽  
Regulatory T Cell ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Dose Finding ◽  
Open Label ◽  
Cell Responses

scholarly journals Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability

Diabetologia ◽  
2020 ◽  
Vol 63 (5) ◽  
pp. 987-1001
Author(s):  
Jing Zhang ◽  
Longmin Chen ◽  
Faxi Wang ◽  
Yuan Zou ◽  
Jingyi Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Stability

scholarly journals Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”

2017 ◽  
Vol 214 (7) ◽  
pp. 2157-2159
Author(s):  
Carolin Daniel ◽  
Benno Weigmann ◽  
Harald von Boehmer
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Preventive Effect ◽  
Peptide Therapy ◽  
Cell Conversion

In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.

scholarly journals A Mimic of Viral Double-Stranded RNA Triggers Fulminant Type 1 Diabetes-like Syndrome in Regulatory T Cell-Deficient Autoimmune Diabetic Mouse

2011 ◽  
Vol 187 (10) ◽  
pp. 4947-4953 ◽  
Author(s):  
Ai Tada ◽  
Akira Shimada ◽  
Taketo Yamada ◽  
Yoichi Oikawa ◽  
Yoshifumi Yamada ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Diabetic Mouse ◽  
Fulminant Type 1 Diabetes ◽  
Double Stranded Rna ◽  
Fulminant Type

Treatment of type 1 diabetes by regulatory T‐cell infusion via regulating the expression of inflammatory cytokines

2019 ◽  
Vol 120 (12) ◽  
pp. 19338-19344 ◽  
Author(s):  
Guofeng Wang ◽  
Yongxin Yan ◽  
Ning Xu ◽  
Dong Yin ◽  
Yuan Hui
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Inflammatory Cytokines ◽  
Regulatory T Cell

scholarly journals Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it?

Diabetologia ◽  
2017 ◽  
Vol 60 (10) ◽  
pp. 1839-1850 ◽  
Author(s):  
Caroline M. Hull ◽  
Mark Peakman ◽  
Timothy I. M. Tree
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Dysfunction ◽  
T Cell Dysfunction

scholarly journals Increased resistance to CD4+ CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

2008 ◽  
Vol 154 (3) ◽  
pp. 353-359 ◽  
Author(s):  
J. M. Lawson ◽  
J. Tremble ◽  
C. Dayan ◽  
H. Beyan ◽  
R. D. G. Leslie ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell

scholarly journals 1,25-Dihydroxyvitamin D3 and Its Analog TX527 Promote a Stable Regulatory T Cell Phenotype in T Cells from Type 1 Diabetes Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109194 ◽  
Author(s):  
Tom L. Van Belle ◽  
An-Sofie Vanherwegen ◽  
Dorien Feyaerts ◽  
Pierre De Clercq ◽  
Annemieke Verstuyf ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Phenotype ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Diabetes Patients

scholarly journals Regulatory T cell therapy for type 1 diabetes: May the force be with you

2016 ◽  
Vol 71 ◽  
pp. 78-87 ◽  
Author(s):  
Stephen E. Gitelman ◽  
Jeffrey A. Bluestone
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
T Cell Therapy
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