scholarly journals Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”

2017 ◽  
Vol 214 (7) ◽  
pp. 2157-2159
Author(s):  
Carolin Daniel ◽  
Benno Weigmann ◽  
Harald von Boehmer
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Preventive Effect ◽  
Peptide Therapy ◽  
Cell Conversion

In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.

scholarly journals Tolerogenic insulin peptide therapy precipitates type 1 diabetes

2017 ◽  
Vol 214 (7) ◽  
pp. 2153-2156 ◽  
Author(s):  
Marie-Louise Bergman ◽  
Thiago Lopes-Carvalho ◽  
Ana-Catarina Martins ◽  
Fabio A. Grieco ◽  
Décio L. Eizirik ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Disease Onset ◽  
Osmotic Pump ◽  
Preventive Effect ◽  
Peptide Therapy ◽  
Pump Delivery

Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.

scholarly journals Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

PLoS Medicine ◽  
2016 ◽  
Vol 13 (10) ◽  
pp. e1002139 ◽  
Author(s):  
John A. Todd ◽  
Marina Evangelou ◽  
Antony J. Cutler ◽  
Marcin L. Pekalski ◽  
Neil M. Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
T Cell ◽  
Regulatory T Cell ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Dose Finding ◽  
Open Label ◽  
Cell Responses

scholarly journals Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability

Diabetologia ◽  
2020 ◽  
Vol 63 (5) ◽  
pp. 987-1001
Author(s):  
Jing Zhang ◽  
Longmin Chen ◽  
Faxi Wang ◽  
Yuan Zou ◽  
Jingyi Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Stability

scholarly journals A Mimic of Viral Double-Stranded RNA Triggers Fulminant Type 1 Diabetes-like Syndrome in Regulatory T Cell-Deficient Autoimmune Diabetic Mouse

2011 ◽  
Vol 187 (10) ◽  
pp. 4947-4953 ◽  
Author(s):  
Ai Tada ◽  
Akira Shimada ◽  
Taketo Yamada ◽  
Yoichi Oikawa ◽  
Yoshifumi Yamada ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Diabetic Mouse ◽  
Fulminant Type 1 Diabetes ◽  
Double Stranded Rna ◽  
Fulminant Type

Treatment of type 1 diabetes by regulatory T‐cell infusion via regulating the expression of inflammatory cytokines

2019 ◽  
Vol 120 (12) ◽  
pp. 19338-19344 ◽  
Author(s):  
Guofeng Wang ◽  
Yongxin Yan ◽  
Ning Xu ◽  
Dong Yin ◽  
Yuan Hui
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Inflammatory Cytokines ◽  
Regulatory T Cell

Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes

Diabetologia ◽  
2014 ◽  
Vol 57 (7) ◽  
pp. 1428-1436 ◽  
Author(s):  
Michael S. Turner ◽  
Kumiko Isse ◽  
Douglas K. Fischer ◽  
Hēth R. Turnquist ◽  
Penelope A. Morel
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Signal Strength ◽  
Cell Populations

scholarly journals Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it?

Diabetologia ◽  
2017 ◽  
Vol 60 (10) ◽  
pp. 1839-1850 ◽  
Author(s):  
Caroline M. Hull ◽  
Mark Peakman ◽  
Timothy I. M. Tree
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Dysfunction ◽  
T Cell Dysfunction

scholarly journals Increased resistance to CD4+ CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

2008 ◽  
Vol 154 (3) ◽  
pp. 353-359 ◽  
Author(s):  
J. M. Lawson ◽  
J. Tremble ◽  
C. Dayan ◽  
H. Beyan ◽  
R. D. G. Leslie ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell

scholarly journals 1,25-Dihydroxyvitamin D3 and Its Analog TX527 Promote a Stable Regulatory T Cell Phenotype in T Cells from Type 1 Diabetes Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109194 ◽  
Author(s):  
Tom L. Van Belle ◽  
An-Sofie Vanherwegen ◽  
Dorien Feyaerts ◽  
Pierre De Clercq ◽  
Annemieke Verstuyf ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Phenotype ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Diabetes Patients
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