1674-P: Age of Onset Is Associated with Insulin Resistance in Patients with Type 1 Diabetes Mellitus

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1674-P
Author(s):  
DAIZHI YANG ◽  
XUEYING WEI ◽  
CHAOFAN WANG ◽  
XUEYING ZHENG ◽  
SIHUI LUO ◽  
...  
Metabolism ◽  
2015 ◽  
Vol 64 (12) ◽  
pp. 1629-1639 ◽  
Author(s):  
Kirti Kaul ◽  
Maria Apostolopoulou ◽  
Michael Roden

Author(s):  
Helena Vavrova

Type l diabetes is one of the most common chronic diseases, even in childhood. New data sugest a trend towards a decreasing age of onset of type 1 Diabetes mellitus.


Author(s):  
Sultan Ali Alshehri ◽  
Sultan Abdulwahab M. Asiri ◽  
Aalaa Mohammad Algarni ◽  
Manal Mohammed Alamari

Background: Type 1 diabetes mellitus is the main risk factor for cardiovascular complications. Therefore, intensified insulin therapy might be needed to achieve better glycemic control in some patients. However, insulin therapy might lead to increase body weight and induce hypoglycemia. Increase body weight is directly correlated to insulin resistance, the main factor for cardiovascular risk.  Objective: To assess the effectiveness of adding SGLT2 inhibitors to insulin therapy in type 1 diabetes mellitus.  Methods: We searched in the PubMed database looking for relevant articles on the topic. We used Mesh words search, including SGLT2 inhibitor, sotagliflozin, type 1 diabetes mellitus, insulin treatment.  Conclusion: Adding oral antidiabetic agents, such as SGLT2 or dual SGLT inhibitors to insulin regimen might be beneficial in improving insulin resistance. Thus, it achieved better insulin resistance by decrease daily insulin requirements and bodyweight control, leading to better cardiovascular outcomes among Type-1 diabetes patients.


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