scholarly journals Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism

Diabetes ◽  
2021 ◽  
pp. db210397
Author(s):  
Ruifang Li-Gao ◽  
David A. Hughes ◽  
Jan B. van Klinken ◽  
Renée de Mutsert ◽  
Frits R. Rosendaal ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Genetic Studies ◽  
Liquid Meal ◽  
Glucose And Lipid Metabolism

scholarly journals Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism

2021 ◽  
Author(s):  
Ruifang Li-Gao ◽  
David A. Hughes ◽  
Jan B. van Klinken ◽  
Renée de Mutsert ◽  
Frits R. Rosendaal ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Association Studies ◽  
P Value ◽  
Genome Wide Association Studies ◽  
Insulinogenic Index ◽  
Genetic Studies ◽  
Liquid Meal ◽  
Glucose And Lipid Metabolism ◽  
Matsuda Index ◽  
The Uk

Humans spend the greater part of the day in a postprandial state. However, the genetic basis of postprandial blood measures is relatively uncharted territory. We set out to examine the genetics of variation in concentrations of postprandial metabolites (t=150 min) in response to a liquid mixed meal through genome-wide association studies (GWAS) performed in the Netherlands Epidemiology of Obesity study (N=5,705). The metabolite response GWAS identified an association between glucose change and rs10830963:G in the melatonin receptor 1B (beta (SE): -0.23 (0.03), P-value: 2.15×10<sup>-19</sup>). In addition, <i>ANKRD55</i> locus led by rs458741:C showed strong associations to extremely large VLDL particle (XXLVLDL) response (with XXLVLDLC: beta (SE): 0.17 (0.03) P-value: 5.76×10<sup>-10 </sup>and with XXLVLDLCE: beta (SE): 0.17 (0.03), P-value: 9.74×10<sup>-10</sup>), which also revealed strong associations to body composition and diabetes in the UK Biobank (p-values<5×10<sup>-8</sup>). Furthermore, the associations between XXLVLDL response and insulinogenic index, HOMA-β, ISI matsuda index and HbA1c in the NEO study further implied the role of chylomicron synthesis in diabetes (with FDR corrected q-value<0.05). To conclude, genetic studies of metabolomics change after a liquid meal illuminate novel pathways for glucose and lipid metabolism. Further studies are warranted to corroborate biological pathways of <i>ANKRD55</i> locus underlying diabetes.

scholarly journals Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism

2021 ◽  
Author(s):  
Ruifang Li-Gao ◽  
David A. Hughes ◽  
Jan B. van Klinken ◽  
Renée de Mutsert ◽  
Frits R. Rosendaal ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Association Studies ◽  
P Value ◽  
Genome Wide Association Studies ◽  
Insulinogenic Index ◽  
Genetic Studies ◽  
Liquid Meal ◽  
Glucose And Lipid Metabolism ◽  
Matsuda Index ◽  
The Uk

Humans spend the greater part of the day in a postprandial state. However, the genetic basis of postprandial blood measures is relatively uncharted territory. We set out to examine the genetics of variation in concentrations of postprandial metabolites (t=150 min) in response to a liquid mixed meal through genome-wide association studies (GWAS) performed in the Netherlands Epidemiology of Obesity study (N=5,705). The metabolite response GWAS identified an association between glucose change and rs10830963:G in the melatonin receptor 1B (beta (SE): -0.23 (0.03), P-value: 2.15×10<sup>-19</sup>). In addition, <i>ANKRD55</i> locus led by rs458741:C showed strong associations to extremely large VLDL particle (XXLVLDL) response (with XXLVLDLC: beta (SE): 0.17 (0.03) P-value: 5.76×10<sup>-10 </sup>and with XXLVLDLCE: beta (SE): 0.17 (0.03), P-value: 9.74×10<sup>-10</sup>), which also revealed strong associations to body composition and diabetes in the UK Biobank (p-values<5×10<sup>-8</sup>). Furthermore, the associations between XXLVLDL response and insulinogenic index, HOMA-β, ISI matsuda index and HbA1c in the NEO study further implied the role of chylomicron synthesis in diabetes (with FDR corrected q-value<0.05). To conclude, genetic studies of metabolomics change after a liquid meal illuminate novel pathways for glucose and lipid metabolism. Further studies are warranted to corroborate biological pathways of <i>ANKRD55</i> locus underlying diabetes.

1060-P: The Effect of FGF21/GLP-1 Fusion Protein on Glucose and Lipid Metabolism Using Diabetic Mice Models

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1060-P
Author(s):  
LIXIN GUO ◽  
QI PAN ◽  
CHAO CHEN ◽  
SHUSHAN LIN ◽  
YU LI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Fusion Protein ◽  
Diabetic Mice ◽  
Glucose And Lipid Metabolism

1878-P: The Role and Potential Mechanism of LncRNA Gm15441 in Skeletal Muscle Glucose and Lipid Metabolism

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1878-P
Author(s):  
LIANGHUI YOU ◽  
YU ZENG ◽  
NAN GU ◽  
CHENBO JI
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Potential Mechanism ◽  
Glucose And Lipid Metabolism

scholarly journals High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights into Its Antimicrobial Potential

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1981 ◽  
Author(s):  
Qiufen Mo ◽  
Aikun Fu ◽  
Lingli Deng ◽  
Minjie Zhao ◽  
Yang Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Systemic Inflammation ◽  
Body Weight Gain ◽  
High Dose ◽  
Dependent Manner ◽  
Glucose And Lipid Metabolism ◽  
Glycerol Monolaurate ◽  
Indigenous Microbiota ◽  
Anti Inflammatory ◽  
Dose Dependent

Glycerol monolaurate (GML) has potent antimicrobial and anti-inflammatory activities. The present study aimed to assess the dose-dependent antimicrobial-effects of GML on the gut microbiota, glucose and lipid metabolism and inflammatory response in C57BL/6 mice. Mice were fed on diets supplemented with GML at dose of 400, 800 and 1600 mg kg−1 for 4 months, respectively. Results showed that supplementation of GML, regardless of the dosages, induced modest body weight gain without affecting epididymal/brown fat pad, lipid profiles and glycemic markers. A high dose of GML (1600 mg kg−1) showed positive impacts on the anti-inflammatory TGF-β1 and IL-22. GML modulated the indigenous microbiota in a dose-dependent manner. It was found that 400 and 800 mg kg−1 GML improved the richness of Barnesiella, whereas a high dosage of GML (1600 mg kg−1) significantly increased the relative abundances of Clostridium XIVa, Oscillibacter and Parasutterella. The present work indicated that GML could upregulate the favorable microbial taxa without inducing systemic inflammation and dysfunction of glucose and lipid metabolism.

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