<b>OBJECTIVE</b>
<p><a>To
investigate whether intraindividual variability of fasting glucose (FG) in
young adulthood is associated with coronary artery calcification (CAC)
progression in middle age.</a></p>
<p><b>RESEARCH DESIGN
AND METHODS</b></p>
<p>We
included 2,256 CARDIA (<a></a><a>Coronary Artery Risk Development Study in Young
Adults</a>) participants with CAC assessment by computed tomography scanner
at baseline (2000–2001) and 10 years later (2010-2011). CAC progression was assessed
for each individual as the difference of logarithmic CAC scores at follow-up
and baseline (log [CAC (follow-up) + 1] - log [CAC (baseline) + 1]). FG
variability was defined by the coefficient of variation about the mean FG
(FG-CV), the SD of FG (FG-SD), and the average real variability of FG (FG-ARV) during
10-year follow-up. We investigated the association between FG variability and
CAC progression with adjustment for demographics, clinical risk factors, mean
FG level, change in FG level, diabetes incidence and medication use.</p>
<p><b>RESULTS</b></p>
<p>After
multivariable adjustment, 1-SD increment in FG-CV was associated with worse progression
of CAC as demonstrated as percent change in CAC with 5.9% (incident CAC, 95% CI
1.0%, 10.7%) and 6.7% (any CAC progression, 95% CI 2.3%, 11.1%) progression during
10 years. Similar findings were also observed in FG-SD and FG-ARV.</p>
<p><b>CONCLUSIONS</b></p>
<p>Higher
FG variability during young adulthood was associated with greater CAC
progression in middle age, suggesting its value in predicting risk for
subclinical coronary artery diseases.</p>
Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
