Insulin Binding and Glucose Transport in Adipocytes in Neonatal Streptozocin-Injected Rat Model of Diabetes Mellitus

Diabetes ◽  
1987 ◽  
Vol 36 (5) ◽  
pp. 654-660 ◽  
Author(s):  
I. G. Fantus ◽  
R. Chayoth ◽  
L. O'Dea ◽  
E. B. Marliss ◽  
J.-F. Yale ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Transport ◽  
Rat Model ◽  
Insulin Binding

Insulin binding and glucose transport in adipocytes in neonatal streptozocin-injected rat model of diabetes mellitus

Diabetes ◽  
1987 ◽  
Vol 36 (5) ◽  
pp. 654-660 ◽  
Author(s):  
I. G. Fantus ◽  
R. Chayoth ◽  
L. O'Dea ◽  
E. B. Marliss ◽  
J. F. Yale ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Transport ◽  
Rat Model ◽  
Insulin Binding

scholarly journals Early Renoprotective Effect of Ruxolitinib in a Rat Model of Diabetic Nephropathy

2021 ◽  
Vol 14 (7) ◽  
pp. 608
Author(s):  
Mohamed M. El-Kady ◽  
Reham A. Naggar ◽  
Maha Guimei ◽  
Iman M. Talaat ◽  
Olfat G. Shaker ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Disease ◽  
Rat Model ◽  
Diabetic Kidney Disease ◽  
Tubulointerstitial Fibrosis ◽  
Favorable Effect ◽  
Glomerular Sclerosis ◽  
Diabetic Kidney ◽  
Renoprotective Effect ◽  
Tgf Β1

Diabetic kidney disease (DKD) is still one of the unresolved major complications of diabetes mellitus, which leads ultimately to end-stage renal disease in both type 1 and type 2 diabetes patients. Available drugs that suppress the renin–angiotensin system have partially minimized the disease impact. Yet, there is an unmet need for new therapeutic interventions to protect the kidneys of diabetic patients. In DN, glomerular sclerosis and tubulointerstitial fibrosis are mediated through several pathways, of which JAK/STAT is a key one. The current study explored the potential renoprotective effect of the JAK1/JAK2 inhibitor ruxolitinib (at doses of 0.44, 2.2, and 4.4 mg·kg−1) compared to that of enalapril at a dose of 10 mg·kg−1, in a rat model of streptozotocin-induced diabetes mellitus over 8 weeks. The effect of ruxolitinib was assessed by determining urinary albumin/creatinine ratio, serum level of cystatin, and levels of TGF-β1, NF-κB, and TNF-α in renal tissue homogenates by biochemical assays, the glomerular sclerosis and tubulointerstitial fibrosis scores by histological analysis, and fibronectin, TGF-β1, and Vimentin levels by immunohistochemical staining with the respective antibodies. Our results revealed a significant early favorable effect of a two-week ruxolitinib treatment on the renal function, supported by a decline in the proinflammatory biomarkers of DKD. This pre-clinical study suggests that the renoprotective effect of ruxolitinib in the long term should be investigated in animals, as this drug may prove to be a potential option for the treatment of diabetic kidney disease.

Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study

2015 ◽  
Vol 31 (5) ◽  
pp. 388-391 ◽  
Author(s):  
Oytun Erbas ◽  
Halil Gursoy Pala ◽  
Emel Ebru Pala ◽  
Burcu Artunc Ulkumen ◽  
Levent Akman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Model Study ◽  
Experimental Rat Model

CARDIOPROTECTIVE EFFECTS OF DIALLYL TRISULFIDE IN A RAT MODEL OF TYPE-1 DIABETES MELLITUS

2018 ◽  
Vol 25 (3) ◽  
pp. 217
Author(s):  
Jovana Jeremic ◽  
Ivan Srejovic ◽  
Vladimir Zivkovic ◽  
Tamara Nikolic Turnic ◽  
Isidora Milosavljevic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Rat Model ◽  
Diallyl Trisulfide ◽  
Cardioprotective Effects

scholarly journals Role of TLR4/MyD88/NF-κB signaling in heart and liver-related complications in a rat model of type 2 diabetes mellitus

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199759
Author(s):  
Jiajia Tian ◽  
Yanyan Zhao ◽  
Lingling Wang ◽  
Lin Li
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Signaling Pathway ◽  
Rat Model ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Primary Response ◽  
Monocyte Chemoattractant Protein 1

Aims To analyze expression of members of the Toll-like receptor (TLR)4/myeloid differentiation primary response 88 (MyD88)/nuclear factor (NF)-κB signaling pathway in the heart and liver in a rat model of type 2 diabetes mellitus (T2DM). Our overall goal was to understand the underlying pathophysiological mechanisms. Methods We measured fasting blood glucose (FBG) and insulin (FINS) in a rat model of T2DM. Expression of members of the TLR4/MyD88/NF-κB signaling pathway as well as downstream cytokines was investigated. Levels of mRNA and protein were assessed using quantitative real-time polymerase chain reaction and western blotting, respectively. Protein content of tissue homogenates was assessed using enzyme-linked immunosorbent assays. Results Diabetic rats had lower body weights, higher FBG, higher FINS, and higher intraperitoneal glucose tolerance than normal rats. In addition, biochemical indicators related to heart and liver function were elevated in diabetic rats compared with normal rats. TLR4 and MyD88 were involved in the occurrence of T2DM as well as T2DM-related heart and liver complications. TLR4 caused T2DM-related heart and liver complications through activation of NF-κB. Conclusions TLR4/MyD88/NF-κB signaling induces production of tumor necrosis factor-α, interleukin-6, and monocyte chemoattractant protein-1, leading to the heart- and liver-related complications of T2DM.

Antioxidant effects of a grape seed extract in a rat model of diabetes mellitus

2009 ◽  
Vol 6 (3) ◽  
pp. 200-204 ◽  
Author(s):  
Irina C. Chis ◽  
Marius I. Ungureanu ◽  
Adriana Marton ◽  
Ramona Simedrea ◽  
Adriana Muresan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Rat Model ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Antioxidant Effects
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