Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse

Diabetes ◽  
1997 ◽  
Vol 46 (7) ◽  
pp. 1124-1132 ◽  
Author(s):  
D. Zekzer ◽  
F. S. Wong ◽  
L. Wen ◽  
M. Altieri ◽  
T. Gurlo ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Clone ◽  
Diabetic Mouse ◽  
Cd4 T Cell ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic ◽  
T Cell Clone

Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse

Diabetes ◽  
1997 ◽  
Vol 46 (7) ◽  
pp. 1124-1132 ◽  
Author(s):  
D. Zekzer ◽  
F. S. Wong ◽  
L. Wen ◽  
M. Altieri ◽  
T. Gurlo ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Clone ◽  
Diabetic Mouse ◽  
Cd4 T Cell ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic ◽  
T Cell Clone

scholarly journals Transfer of protective immunity in murine histoplasmosis by a CD4+ T-cell clone.

1993 ◽  
Vol 61 (2) ◽  
pp. 714-718 ◽  
Author(s):  
R Allendoerfer ◽  
D M Magee ◽  
G S Deepe ◽  
J R Graybill
Keyword(s):  
T Cell ◽  
Protective Immunity ◽  
Cell Clone ◽  
Cd4 T Cell ◽  
T Cell Clone

Tachyzoite-specific isoform of Toxoplasma gondii lactate dehydrogenase is the target antigen of a murine CD4+ T-cell clone

2001 ◽  
Vol 3 (10) ◽  
pp. 779-787 ◽  
Author(s):  
Gaby Reichmann ◽  
Henryka Długońska ◽  
Ela Hiszczyńska-Sawicka ◽  
Hans-Georg Fischer
Keyword(s):  
Lactate Dehydrogenase ◽  
T Cell ◽  
Toxoplasma Gondii ◽  
Cell Clone ◽  
Cd4 T Cell ◽  
Target Antigen ◽  
T Cell Clone

scholarly journals Targeting of a T Cell Agonist Peptide to Lysosomes by DNA Vaccination Induces Tolerance in the Nonobese Diabetic Mouse

2011 ◽  
Vol 186 (7) ◽  
pp. 4078-4087 ◽  
Author(s):  
Elisa I. Rivas ◽  
John P. Driver ◽  
Nahir Garabatos ◽  
Maximiliano Presa ◽  
Conchi Mora ◽  
...  
Keyword(s):  
T Cell ◽  
Diabetic Mouse ◽  
Dna Vaccination ◽  
Nonobese Diabetic Mouse ◽  
Agonist Peptide ◽  
Nonobese Diabetic

scholarly journals Characterization of an I-E-Restricted, gp63-Specific, CD4-T-Cell Clone from Leishmania major-Resistant C3H Mice That Secretes Type 2 Cytokines and Exacerbates Infection with L. major

2004 ◽  
Vol 72 (8) ◽  
pp. 4486-4493
Author(s):  
Cynthia M. Theodos ◽  
Robin V. Morris ◽  
Jeanette V. Bishop ◽  
Jeremy D. Jones ◽  
W. Robert McMaster ◽  
...  
Keyword(s):  
T Cell ◽  
Leishmania Major ◽  
Transforming Growth Factor ◽  
Cell Clone ◽  
Parasite Burden ◽  
Cd4 T Cell ◽  
Amino Terminal ◽  
T Cell Clone ◽  
C3h Mice

ABSTRACT A T-cell clone (designated KLmB-3) was derived from resistant C3H mice 2 weeks after infection with Leishmania major. KLmB-3 was a CD4-T-cell clone that utilized the Vβ8.1 T-cell receptor. When adoptively transferred to naive C3H mice, KLmB-3 unexpectedly exacerbated infection with L. major (it increased the cutaneous lesion size and the parasite burden within the lesion). The ability of KLmB-3 to exacerbate disease correlated with its ability to produce the type 2-associated cytokines interleukin-4 (IL-4), IL-5, IL-10, and transforming growth factor beta. Interestingly, KLmB-3 was specific for an epitope in the amino-terminal end of the L. major surface gp63 zinc metalloproteinase (leishmanolysin) that has been shown to be capable of inducing a protective immune response. Moreover, KLmB-3 was activated when this epitope was presented in the context of H-2 I-E rather than H-2 I-A.

scholarly journals Immunization with soluble BDC 2.5 T cell receptor-immunoglobulin chimeric protein:antibody specificity and protection of nonobese diabetic mice against adoptive transfer of diabetes by maternal immunization.

1996 ◽  
Vol 184 (5) ◽  
pp. 1755-1768 ◽  
Author(s):  
U McKeever ◽  
S Khandekar ◽  
J Newcomb ◽  
J Naylor ◽  
P Gregory ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Adoptive Transfer ◽  
Cell Clone ◽  
Nod Mice ◽  
Cell Receptor ◽  
Transfer Model ◽  
Maternal Immunization ◽  
Nonobese Diabetic ◽  
T Cell Clone

The BDC 2.5 T cell clone is specific for pancreatic beta-cell antigen presented by I-Ag7, and greatly accelerates diabetes when injected into 10-21-d-old nonobese diabetic (NOD) mice. The BDC 2.5 T cell receptor (TCR) has been solubilized as a TCR-IgG1 chimeric protein. All NOD mice immunized against BDC 2.5 TCR-IgG1 produced antibodies recognizing TCR C alpha/C beta epitopes that were inaccessible on the T cell surface. 56% of the mice produced antibodies against the BDC 2.5 clonotype that specifically blocked antigen activation of BDC 2.5 cells. We have used the adoptive transfer model of diabetes to demonstrate that maternal immunization with soluble TCR protects young mice from diabetes induced by the BDC 2.5 T cell clone.

Generation of an Immortalized Human CD4+ T Cell Clone Inhibiting Tumor Growth in Mice

2001 ◽  
Vol 283 (4) ◽  
pp. 738-742 ◽  
Author(s):  
Gabriele Pecher ◽  
Ulf Harnack ◽  
Matthias Günther ◽  
Michael Hummel ◽  
Iduna Fichtner ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Growth ◽  
Cell Clone ◽  
Cd4 T Cell ◽  
T Cell Clone
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