Deficient axonal transport of substance P in streptozocin-induced diabetic rats. Effects of sorbinil and insulin

Diabetes ◽  
1988 ◽  
Vol 37 (4) ◽  
pp. 488-493 ◽  
Author(s):  
D. R. Tomlinson ◽  
J. P. Robinson ◽  
G. B. Willars ◽  
P. Keen
Keyword(s):  
Substance P ◽  
Axonal Transport ◽  
Diabetic Rats

Axonal transport of substance P-like immunoreactivity in ganglioside-treated diabetic rats

1990 ◽  
Vol 96 (2-3) ◽  
pp. 283-291 ◽  
Author(s):  
Nigel A. Calcutt ◽  
David R. Tomlinson ◽  
Gary B. Willars ◽  
Peter Keen
Keyword(s):  
Substance P ◽  
Axonal Transport ◽  
Diabetic Rats

Deficient Axonal Transport of Substance P in Streptozocin-Induced Diabetic Rats: Effects of Sorbinil and Insulin

Diabetes ◽  
1988 ◽  
Vol 37 (4) ◽  
pp. 488-493 ◽  
Author(s):  
D. R. Tomlinson ◽  
J. P. Robinson ◽  
G. B. Willars ◽  
P. Keen
Keyword(s):  
Substance P ◽  
Axonal Transport ◽  
Diabetic Rats

Changes of substance P and somatostatin contents in the gastrointestinal tract of streptozotocin diabetic rats

1991 ◽  
Vol 129 (2) ◽  
pp. 173-176 ◽  
Author(s):  
Takeo Karakida ◽  
Masaharu Sakai ◽  
Seiki Ito ◽  
Yukio Yamada ◽  
Shinji Homma
Keyword(s):  
Gastrointestinal Tract ◽  
Substance P ◽  
Diabetic Rats ◽  
Streptozotocin Diabetic Rats

scholarly journals Impaired axonal transport of acetylcholinesterase in the sciatic nerve of alloxan-diabetic rats: effect of ganglioside treatment

Diabetologia ◽  
1986 ◽  
Vol 29 (4) ◽  
pp. 254-258 ◽  
Author(s):  
P. Marini ◽  
M. Vitadello ◽  
R. Bianchi ◽  
C. Triban ◽  
A. Gorio
Keyword(s):  
Sciatic Nerve ◽  
Axonal Transport ◽  
Diabetic Rats

scholarly journals Spatial Distribution of Nociceptive Neuropeptide and Nerve Growth Factor Depletion in Experimental Diabetic Peripheral Nervous System

2002 ◽  
Vol 30 (5) ◽  
pp. 512-519 ◽  
Author(s):  
H Kanbayashi ◽  
H Itoh ◽  
T Kashiwaya ◽  
K Atoh ◽  
I Makino
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Substance P ◽  
Dorsal Root ◽  
Time Course ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dependent Manner ◽  
Nerve Growth

This study investigated the time-course of the nociceptive neuropeptide substance P and nerve growth factor (NGF), which facilitates substance P production, in lumbar and cervical dorsal root ganglia (DRG) of streptozotocin-induced diabetic rats. Levels of substance P and NGF were measured by radioimmunoassay and sandwich enzyme-linked immunosorbent assay, respectively, 2 months, 4 months and 8 months after induction of diabetes, and compared with age-matched non-diabetic control rats. At 2 months and 4 months, substance P and NGF levels were lower in the lumbar DRG of the diabetic rats than in controls. At 8 months, substance P and NGF were lower in both the lumbar and cervical DRG of the diabetic rats than in controls. These data demonstrate that a decrease in substance P levels in primary sensory neurons with NGF depletion occurs in an axonal length-dependent manner in diabetic rats, and that this decrease may be correlated with the duration of diabetes.

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