scholarly journals Diabetes and Abnormal Glucose Tolerance in Women With Previous Gestational Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (4) ◽  
pp. 1199-1205 ◽  
Author(s):  
M. Albareda ◽  
A. Caballero ◽  
G. Badell ◽  
S. Piquer ◽  
A. Ortiz ◽  
...  
2013 ◽  
Vol 169 (5) ◽  
pp. 681-687 ◽  
Author(s):  
E Noctor ◽  
C Crowe ◽  
L A Carmody ◽  
G M Avalos ◽  
B Kirwan ◽  
...  

ObjectivePrevious gestational diabetes (GDM) is associated with a significant lifetime risk of type 2 diabetes. In this study, we assessed the performance of HbA1c and fasting plasma glucose (FPG) measurements against that of 75 g oral glucose tolerance testing (OGTT) for the follow-up screening of women with previous GDM.MethodsTwo hundred and sixty-six women with previous GDM underwent the follow-up testing (mean of 2.6 years (s.d. 1.0) post-index pregnancy) using HbA1c (100%), and 75 g OGTT (89%) or FPG (11%). American Diabetes Association (ADA) criteria for abnormal glucose tolerance were used.Design, cohort study, and resultsThe ADA HbA1c high-risk cut-off of 39 mmol/mol yielded sensitivity of 45% (95% CI 32, 59), specificity of 84% (95% CI 78, 88), negative predictive value (NPV) of 87% (95% CI 82, 91) and positive predictive value (PPV) of 39% (95% CI 27, 52) for detecting abnormal glucose tolerance. ADA high-risk criterion for FPG of 5.6 mmol/l showed sensitivity of 80% (95% CI 66, 89), specificity of 100% (95% CI 98, 100), NPV of 96% (95% CI 92, 98) and PPV of 100% (95% CI 91, 100). Combining HbA1c ≥39 mmol/mol with FPG ≥5.6 mmol/l yielded sensitivity of 90% (95% CI 78, 96), specificity of 84% (95% CI 78, 88), NPV of 97% (95% CI 94, 99) and PPV of 56% (95% CI 45, 66).ConclusionsCombining test cut-offs of 5.6 mmol/l and HbA1c 39 mmol/mol identifies 90% of women with abnormal glucose tolerance post-GDM (mean 2.6 years (s.d.1.0) post-index pregnancy). Applying this follow-up strategy will reduce the number of OGTT tests required by 70%, will be more convenient for women and their practitioners, and is likely to lead to increased uptake of long-term retesting by these women whose risk for type 2 diabetes is substantially increased.


2018 ◽  
Vol 131 ◽  
pp. 36S
Author(s):  
Christopher A. Enakpene ◽  
Tiffany Jones ◽  
Dimitrios Mastrogiannis ◽  
Micaela Della Torre ◽  
Lauren Knazze ◽  
...  

2021 ◽  
Vol 6 (2) ◽  
pp. 58
Author(s):  
Shradha Shrestha ◽  
Sharmin Jahan ◽  
Nusrat Sultana ◽  
Mohammad Fakhrul Alam ◽  
Yasmin Akter ◽  
...  

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