scholarly journals Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Autoimmune Encephalomyelitis

2006 ◽  
Vol 168 (4) ◽  
pp. 1179-1188 ◽  
Author(s):  
Elena Gonzalez-Rey ◽  
Amelia Fernandez-Martin ◽  
Alejo Chorny ◽  
Javier Martin ◽  
David Pozo ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Vasoactive Intestinal Peptide ◽  
Therapeutic Effect ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

scholarly journals Selected Clostridia Strains from The Human Microbiota and their Metabolite, Butyrate, Improve Experimental Autoimmune Encephalomyelitis

2021 ◽  
Author(s):  
Laura Calvo-Barreiro ◽  
Herena Eixarch ◽  
Thais Cornejo ◽  
Carme Costa ◽  
Mireia Castillo ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Therapeutic Effect ◽  
Clinical Effect ◽  
Short Chain Fatty Acid ◽  
Human Gut ◽  
Autoimmune Encephalomyelitis ◽  
Gut Dysbiosis ◽  
Cns Autoimmunity ◽  
The Central Nervous System ◽  
Experimental Autoimmune

SummaryGut microbiome studies in multiple sclerosis (MS) patients are unravelling some consistent but modest patterns of gut dysbiosis. Among these, a significant decrease of Clostridia cluster IV and XIVa has been reported. In the present study, we investigated the therapeutic effect of a previously selected mixture of human gut-derived 17 Clostridia strains, which belong to Clostridia clusters IV, XIVa, and XVIII, on the clinical outcome of experimental autoimmune encephalomyelitis (EAE). The observed clinical improvement was related to lower demyelination and astrocyte reactivity as well as a tendency to lower microglia reactivity/infiltrating macrophages and axonal damage in the central nervous system (CNS), and to an enhanced immunoregulatory response of regulatory T cells in the periphery. Transcriptome studies also highlighted increased antiinflammatory responses related to interferon beta in the periphery and lower immune responses in the CNS. Since Clostridia-treated mice were found to present higher levels of the immunomodulatory short-chain fatty acid (SCFA) butyrate in the serum, we studied if this clinical effect could be reproduced by butyrate administration alone. Further EAE experiments proved its preventive but slight therapeutic impact on CNS autoimmunity. Thus, this smaller therapeutic effect highlighted that the Clostridia-induced clinical effect was not exclusively related to the SCFA and could not be reproduced by butyrate administration alone. Although it is still unknown if these Clostridia strains will have the same effect on MS patients, gut dysbiosis in MS patients could be partially rebalanced by these commensal bacteria and their immunoregulatory properties could have a beneficial effect on MS clinical course.

scholarly journals Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yuan Zhang ◽  
Xing Li ◽  
Bogoljub Ciric ◽  
Cun-Gen Ma ◽  
Bruno Gran ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Therapeutic Effect ◽  
Regulatory Pathway ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

Therapeutic effect of mbp immunodominant peptides encapsulated in nanovehicles in the development of experimental autoimmune encephalomyelitis in DA rats

2012 ◽  
Vol 38 (3) ◽  
pp. 266-273
Author(s):  
A. V. Stepanov ◽  
A. A. Belogurov ◽  
A. E. Mamedov ◽  
D. Melamed ◽  
I. V. Smirnov ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Therapeutic Effect ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

Therapeutic effect of ghrelin in experimental autoimmune encephalomyelitis by inhibiting antigen-specific Th1/Th17 responses and inducing regulatory T cells

2013 ◽  
Vol 30 ◽  
pp. 54-60 ◽  
Author(s):  
Luciana Souza-Moreira ◽  
Virginia Delgado-Maroto ◽  
Maria Morell ◽  
Francisco O’Valle ◽  
Raimundo G. Del Moral ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Therapeutic Effect ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune
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