scholarly journals CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein

2009 ◽  
Vol 174 (6) ◽  
pp. 2061-2072 ◽  
Author(s):  
Paul Gutwein ◽  
Mohamed Sadek Abdel-Bakky ◽  
Anja Schramme ◽  
Kai Doberstein ◽  
Nicole Kämpfer-Kolb ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells

2005 ◽  
Vol 393 (1) ◽  
pp. 107-115 ◽  
Author(s):  
Jane E. Murphy ◽  
Daryl Tacon ◽  
Philip R. Tedbury ◽  
Jonathan M. Hadden ◽  
Stuart Knowling ◽  
...  
Keyword(s):  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Dependent Manner ◽  
Oxidized Low Density Lipoprotein ◽  
Bivalent Cation ◽  
Calcium Dependent

The LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) scavenger receptor regulates vascular responses to oxidized-low-density-lipoprotein particles implicated in atherosclerotic plaque formation. LOX-1 is closely related to C-type lectins, but the mechanism of ligand recognition is not known. Here we show that human LOX-1 recognizes a key cellular phospholipid, PS (phosphatidylserine), in a Ca2+-dependent manner, both in vitro and in cultured cells. A recombinant, folded and glycosylated LOX-1 molecule binds PS, but not other phospholipids. LOX-1 recognition of PS was maximal in the presence of millimolar Ca2+ levels. Mg2+ was unable to substitute for Ca2+ in LOX-1 binding to PS, indicating a Ca2+-specific requirement for bivalent cations. LOX-1-mediated recognition of PS-containing apoptotic bodies was dependent on Ca2+ and was decreased to background levels by bivalent-cation chelation, LOX-1-blocking antibodies or PS-containing liposomes. The LOX-1 membrane protein is thus a Ca2+-dependent phospholipid receptor, revealing novel recognition of phospholipids by mammalian lectins.

scholarly journals Oxidized Low Density Lipoprotein Decreases Macrophage Expression of Scavenger Receptor B-I

2001 ◽  
Vol 276 (19) ◽  
pp. 16567-16572 ◽  
Author(s):  
Jihong Han ◽  
Andrew C. Nicholson ◽  
Xiaoye Zhou ◽  
Jianwei Feng ◽  
Antonio M. Gotto ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Antagonistic Effects of Oxidized Low Density Lipoprotein and α-Tocopherol on CD36 Scavenger Receptor Expression in Monocytes

2006 ◽  
Vol 281 (10) ◽  
pp. 6489-6497 ◽  
Author(s):  
Adelina Munteanu ◽  
Michele Taddei ◽  
Ilaria Tamburini ◽  
Ettore Bergamini ◽  
Angelo Azzi ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Receptor Expression ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Antagonistic Effects

Binding and Uptake of 125Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of a-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate

1997 ◽  
Vol 52 (1-2) ◽  
pp. 97-104 ◽  
Author(s):  
Daniela Selmer ◽  
Reingard Senekowitsch-Schmidtke ◽  
W. Schneider ◽  
E. F. Elstner
Keyword(s):  
Specific Binding ◽  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Protective Effects ◽  
Oxidized Low Density Lipoprotein ◽  
Unspecific Binding

Abstract Specific and unspecific binding and uptake (internalization) by macrophages of 125iodine -labelled, copper-oxidized human low density lipoprotein is differently influenced by the anti­ oxidants α-tocopherol (α-Toc), probucol (Prob), pyridoxal-5'-phosphate (PP) and the magnesium-pyridoxal-5'-phosphate glutamate complex (MPPG). Binding as well as internalization, mediated by the so-called "scavenger receptor" is lower in the presence of MPPG whereas both specific binding and internalization are enhanced. The comparison of the effects in vitro allows a rating of the potentially anti-atherogenic and thus protective effects of the tested substances as follows: MPPG > PP > α-Toc > Prob.

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