Determination of the initial minimum effective dose of 0.5% bupivacaine with 20 μg of fentanyl for an operative fixation of fractured neck of femur: a prospective, observational trial

2021 ◽  
Vol 87 (7) ◽  
Author(s):  
Tomas HITKA ◽  
Jane O’SULLIVAN ◽  
Szilard SZUCS ◽  
Gabriella IOHOM
Keyword(s):  
Effective Dose ◽  
Minimum Effective Dose ◽  
Fractured Neck Of Femur ◽  
Neck Of Femur ◽  
Observational Trial ◽  
Operative Fixation

scholarly journals On the Methods of Standardising Suprarenal Preparations

1906 ◽  
Vol 26 (1) ◽  
pp. 157-171 ◽  
Author(s):  
I. D. Cameron
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Effective Dose ◽  
Colorimetric Method ◽  
Minimum Effective Dose ◽  
Satisfactory Method

SUMMARYFor the standardisation of adrenalin preparations.(a) The colorimetric method is not reliable with weak or impure solutions.(b) The effect on the pupil of the frog's eye gives uncertain results.(c) The determination of the minimum effective dose on the arterioles of the perfused frog is tedious and uncertain; on an average 0·1 per million produces an effect.(d) The determination of the minimum effective dose in causing a rise on the blood pressure of the atropinised rabbit yields fairly satisfactory results.(e) Adrenalin, suprarenalin, and hemisine all give a precisely similar result, 0·0003 mg. per kilo of body weight, or 0·006 per million, of the rabbit's blood causing a distinct rise in the blood pressure in the rabbit, and 0·012 mg. per kilo of body weight, or 0·24 per million, of the blood causing a rise in the cat.(f) The most satisfactory method is the determination of the dose just sufficient to antagonise 0·6 mg. of nitroglycerin (Parke, Davis & Co.). Of adrenalin, 0·0075 mg. is sufficient.I wish to express my indebtedness to Dr Noël Paton for much help in the preparation of this paper.The expenses of this research were defrayed from a grant made to the Laboratory by Mr J. Francis Mason for investigations on the physiology of the ductless glands.

Lipolytic and hypocalcemic effects of sheep beta-lipotropic hormone

1970 ◽  
Vol 48 (11) ◽  
pp. 762-767 ◽  
Author(s):  
M. Chrétien ◽  
J. Davignon ◽  
M. Lis ◽  
P. V. Chari ◽  
F. Aubry ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Effective Dose ◽  
Chemical Structure ◽  
Minimum Effective Dose ◽  
Short Term ◽  
Hypocalcemic Effect ◽  
Plasma Magnesium ◽  
Fat Pads

Sheep beta-LPH is a hypophyseal lipolytic hormone with defined chemical structure which has been shown to be hypocalcemic when injected into rabbits. The thyroid gland seems to be essential for production of this hypocalcemic effect. Beta-LPH may be a stimulating hormone for calcitonin-secreting cells. It has no effect on plasma magnesium, cholesterol, triglycerides, and glucose, at least in short-term experiments. When intact epididymal fat pads are used for the determination of the LPH lipolytic effect in vitro, a lower minimum effective dose is found than when small pieces are used.

Trial of Aspirin and RA 233 in Prevention of Post-operative Deep Vein Thrombosis

1973 ◽  
Vol 30 (01) ◽  
pp. 018-024 ◽  
Author(s):  
Edward H. Wood ◽  
Colin R.M. Prentice ◽  
D. Angus McGrouther ◽  
John Sinclair ◽  
George P. McNicol
Keyword(s):  
Deep Vein Thrombosis ◽  
Controlled Trial ◽  
Oral Anticoagulants ◽  
Antithrombotic Agent ◽  
Fractured Neck Of Femur ◽  
Neck Of Femur ◽  
Vein Thrombosis ◽  
Effective Prophylaxis ◽  
Deep Vein ◽  
Calf Vein

SummaryAlthough the oral anticoagulants provide effective prophylaxis against postoperative deep vein thrombosis following fracture of neck of femur there is a need for an antithrombotic agent which needs less laboratory control and does not cause haemorrhagic complications. It has been suggested that drugs causing inhibition of platelet function may fulfil these requirements. A controlled trial was carried out in which aspirin, RA 233, or a combination of these drugs was compared with a placebo in the prevention of post-operative deep vein thrombosis. In thirty patients undergoing surgery for fractured neck of femur the incidence of post-operative calf vein thrombosis, as detected by 125I-fibrinogen scanning, was not significantly different between the untreated and treated groups.

102 Peer Teaching in Hip Fracture: Responding to the Medical Needs of Surgical Patients and Educational Needs of Junior Doctors

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
N Jones ◽  
J Francis ◽  
R Parikh ◽  
M Shaath
Keyword(s):  
Metastatic Cancer ◽  
Vascular Complications ◽  
Educational Programme ◽  
Junior Doctors ◽  
Fractured Neck Of Femur ◽  
Neck Of Femur ◽  
Teaching Programme ◽  
Medical Needs ◽  
Strongly Agree ◽  
Case Based

Abstract Introduction Fractured Neck of Femur (FNOF) patients are complex. A mortality project identified topics for a peer-led teaching programme. Method Eight bite-sized case-based sessions were devised, to provide a framework to approach the following topics: Anaemia, delirium/dementia, ECG abnormalities, metastatic cancer, osteoporosis, renal disease, respiratory disease, and vascular complications. Attendees were asked to complete pre- and post- teaching programme questionnaires using a Likert Scale to indicate agreement with statements relating to the topic areas chosen (1=strongly disagree and 5=strongly agree). Result Pre-programme questionnaire: respondents were neutral (average 3.04) when asked whether topic areas were currently “well managed”. Attendees lacked confidence, indicating preparedness as neutral (average 3.35). Trainees agreed that they would benefit from teaching (average 4.56). Post-programme questionnaire: increased confidence was reported when considering preparedness (average 4.3). Attendees felt the teaching programme was “accessible” and the “topics well-chosen”. 100% of attendees regarded the teaching as ‘excellent’ or ‘very-good’. Conclusions Matching patient needs to an educational programme is important. The “bite-sized” nature of the programme paired with case-based learning increased confidence. A peer-led teaching programme is a positive response to themes emerging from morbidity and mortality reviews.

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