scholarly journals On the Methods of Standardising Suprarenal Preparations

1906 ◽  
Vol 26 (1) ◽  
pp. 157-171 ◽  
Author(s):  
I. D. Cameron
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Effective Dose ◽  
Colorimetric Method ◽  
Minimum Effective Dose ◽  
Satisfactory Method

SUMMARYFor the standardisation of adrenalin preparations.(a) The colorimetric method is not reliable with weak or impure solutions.(b) The effect on the pupil of the frog's eye gives uncertain results.(c) The determination of the minimum effective dose on the arterioles of the perfused frog is tedious and uncertain; on an average 0·1 per million produces an effect.(d) The determination of the minimum effective dose in causing a rise on the blood pressure of the atropinised rabbit yields fairly satisfactory results.(e) Adrenalin, suprarenalin, and hemisine all give a precisely similar result, 0·0003 mg. per kilo of body weight, or 0·006 per million, of the rabbit's blood causing a distinct rise in the blood pressure in the rabbit, and 0·012 mg. per kilo of body weight, or 0·24 per million, of the blood causing a rise in the cat.(f) The most satisfactory method is the determination of the dose just sufficient to antagonise 0·6 mg. of nitroglycerin (Parke, Davis & Co.). Of adrenalin, 0·0075 mg. is sufficient.I wish to express my indebtedness to Dr Noël Paton for much help in the preparation of this paper.The expenses of this research were defrayed from a grant made to the Laboratory by Mr J. Francis Mason for investigations on the physiology of the ductless glands.

scholarly journals THE PULMONARY ARTERIAL PRESSURE IN NORMAL ALBINO RATS AND THE EFFECT THEREON OF EPINEPHRINE

1934 ◽  
Vol 59 (2) ◽  
pp. 173-180 ◽  
Author(s):  
F. J. C. Smith ◽  
Granville A. Bennett
Keyword(s):  
Blood Pressure ◽  
Pulmonary Artery ◽  
Arterial Pressure ◽  
Pulmonary Arterial Pressure ◽  
Direct Determination ◽  
Albino Rats ◽  
Satisfactory Method ◽  
Pulmonary Arterial ◽  
Nembutal Anesthesia

1. A satisfactory method for the direct determination of the pulmonary arterial pressure in rats is described. 2. The arithmetical mean of the blood pressure in the pulmonary artery in a series of thirty-four normal albino rats under nembutal anesthesia is 256 mm. H20 (18.8 mm. Hg). 3. Intravenous epinephrine causes an abrupt but briefly sustained rise in the pulmonary arterial pressure with a gradual return to normal.

A milk-derived pentapeptide reduces blood pressure in advanced hypertension in a CCK system-dependent manner

2020 ◽  
Vol 11 (11) ◽  
pp. 9489-9494
Author(s):  
Daiki Koyama ◽  
Masaki Sasai ◽  
Shigenobu Matsumura ◽  
Kazuo Inoue ◽  
Kousaku Ohinata
Keyword(s):  
Blood Pressure ◽  
Effective Dose ◽  
Dependent Manner ◽  
Minimum Effective Dose ◽  
Hypotensive Drugs

Orally administered KFWGK exhibits potent and long-lasting antihypertensive effects in SHR with advanced hypertension, at which known hypotensive drugs are sometimes less effective. The minimum effective dose of KFWGK was 5 μg kg−1.

scholarly journals STUDIES ON EXPERIMENTAL HYPERTENSION

1943 ◽  
Vol 77 (4) ◽  
pp. 309-313 ◽  
Author(s):  
Harry Goldblatt ◽  
Yale J. Katz ◽  
Harvey A. Lewis ◽  
Evelyn Richardson
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Rapid Method ◽  
Standard Method ◽  
Renal Tissue ◽  
The Body ◽  
Experimental Hypertension

A simple, rapid method for the bioassay of renin has been presented. Reliable and consistent results are obtained by this method whereby an arbitrary dog unit of renin has been established. The response of normal unanesthetized dogs to renin is independent of the body weight of dogs weighing between 10 and 25 kilos. An estimate of potency of renin per kilo of body weight of the test animals is therefore not only unnecessary but misleading. A dog unit of renin has been defined as that amount which raises the blood pressure at least 30 and not more than 35 mm. Hg within 3 minutes in at least three unanesthetized dogs. The potency is expressed as dog units of renin per cubic centimeter. The determination of the amount of renal substance represented by a cubic centimeter of extract and the number of dog units per cubic centimeter give an estimate of the yield of renin which can be expressed as dog units of renin per gram of original renal tissue. By determination of the number of dog units per cubic centimeter and the amount of nitrogen in milligrams per cubic centimeter in any renal extract the purity of the renin can be determined and expressed as dog units of renin per milligram N. The establishment of a standard method for the bioassay of renin is considered highly desirable and the method outlined in this paper is suggested for this purpose.

Lipolytic and hypocalcemic effects of sheep beta-lipotropic hormone

1970 ◽  
Vol 48 (11) ◽  
pp. 762-767 ◽  
Author(s):  
M. Chrétien ◽  
J. Davignon ◽  
M. Lis ◽  
P. V. Chari ◽  
F. Aubry ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Effective Dose ◽  
Chemical Structure ◽  
Minimum Effective Dose ◽  
Short Term ◽  
Hypocalcemic Effect ◽  
Plasma Magnesium ◽  
Fat Pads

Sheep beta-LPH is a hypophyseal lipolytic hormone with defined chemical structure which has been shown to be hypocalcemic when injected into rabbits. The thyroid gland seems to be essential for production of this hypocalcemic effect. Beta-LPH may be a stimulating hormone for calcitonin-secreting cells. It has no effect on plasma magnesium, cholesterol, triglycerides, and glucose, at least in short-term experiments. When intact epididymal fat pads are used for the determination of the LPH lipolytic effect in vitro, a lower minimum effective dose is found than when small pieces are used.

Efficacy and safety of drospirenone-containing microdosage combined oral contraceptive use with starting contraception

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 9-13
Author(s):  
A R Khachaturian ◽  
E V Misharina ◽  
M I Yarmolinskaya
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Oral Contraceptive ◽  
Waist Circumference ◽  
Young Women ◽  
Iron Metabolism ◽  
Serum Iron ◽  
The Body ◽  
Menstrual Bleeding ◽  
Combined Oral Contraceptive

Androgen-dependent dermopathy, as well as premenstrual syndrome of varying severity in young women, can cause emotional depression, difficulties in social adaptation and even depressive disorders. The aim of the study was to study the safety and efficacy of using a combined oral contraceptive (COC) Dimia® containing 20 μg ethinyl estradiol and 3 mg drospirenone in young women, as well as its therapeutic effects in androgen-dependent dermopathy. Materials and methods. The study included 57 young women aged 23.1±2.2 years with signs of androgen-dependent dermopathy. The evaluation of the change in the character of menstrual bleeding, the anthropometric parameters (body weight, waist circumference and hips), the therapeutic effect of the drug on the symptoms of androgen-dependent dermopathy, as well as the dynamics of arterial pressure, hemoglobin level, serum iron have been studied. The psycho-emotional state was assessed using the SAN questionnaire (well-being-activity-mood). Results. During 6 months of observation, there was no significant change in the body mass index, waist circumference, and hips, and the drug did not affect the blood pressure numbers. Against the background of taking the drug, there was an increase in the parameters of iron metabolism (hemoglobin content, serum iron). After 3 months of taking the contraceptive with drospirenone, the number of patients with a complaint about the abundance of menstruation decreased more than twofold (from 22.8 to 10.5%), and after 6 months of taking the drug no patient noted the profuse nature of menstruation. Before the start of taking COC with drospirenone, 57.9% of women reported painful menstrual bleeding. Against the background of taking the contraceptive within 3 months, this complaint was stopped in all patients. Sufficient efficacy of treatment of androgen dependent dermopathy in young women with the help of a microdosed drospirenone-containing combined oral contraceptive is estimated from the dermatological acne index. The analysis of the SAN questionnaire made it possible to reveal the improvement in the psychoemotional state of patients on the background of taking the drug. The conclusion. The results obtained proved the effectiveness and safety of the microclinized COC Dimia®. The drug has no significant effect on body weight, blood pressure, provides reliable control of the cycle and a decrease in menstrual bleeding, which results in stabilization of iron metabolism in the body. Dimia® is effective in the treatment of androgen-dependent dermopathy and can be recommended to young women for starting contraception.

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