scholarly journals The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease

2018 ◽  
Vol 37 (3) ◽  
pp. 222-229 ◽  
Author(s):  
Harin Rhee ◽  
Miyeun Han ◽  
Sang Soo Kim ◽  
Il Young Kim ◽  
Hye Won Lee ◽  
...  
2006 ◽  
Vol 366 (1-2) ◽  
pp. 243-248 ◽  
Author(s):  
Horng-Rong Chang ◽  
Shun-Fa Yang ◽  
Mei-Lan Li ◽  
Chiu-Chu Lin ◽  
Yih-Shou Hsieh ◽  
...  

2014 ◽  
Vol 307 (4) ◽  
pp. F407-F417 ◽  
Author(s):  
Alexander Lehners ◽  
Sascha Lange ◽  
Gianina Niemann ◽  
Alva Rosendahl ◽  
Catherine Meyer-Schwesinger ◽  
...  

Myeloperoxidase (MPO) is an enzyme expressed in neutrophils and monocytes/macrophages. Beside its well-defined role in innate immune defence, it may also be responsible for tissue damage. To identify the role of MPO in the progression of chronic kidney disease (CKD), we investigated CKD in a model of renal ablation in MPO knockout and wild-type mice. CKD was induced by 5/6 nephrectomy. Mice were followed for 10 wk to evaluate the impact of MPO deficiency on renal morbidity. Renal ablation induced CKD in wild-type mice with increased plasma levels of MPO compared with controls. No difference was found between MPO-deficient and wild-type mice regarding albuminuria 1 wk after renal ablation, indicating similar acute responses to renal ablation. Over the next 10 wk, however, MPO-deficient mice developed significantly less albuminuria and glomerular injury than wild-type mice. This was accompanied by a significantly lower renal mRNA expression of the fibrosis marker genes plasminogen activator inhibitor-I, collagen type III, and collagen type IV as well as matrix metalloproteinase-2 and matrix metalloproteinase-9. MPO-deficient mice also developed less renal inflammation after renal ablation, as indicated by a lower infiltration of CD3-positive T cells and F4/80-positive monocytes/macrophages compared with wild-type mice. In vitro chemotaxis of monocyte/macrophages isolated from MPO-deficient mice was impaired compared with wild-type mice. No significant differences were observed for mortality and blood pressure after renal ablation. In conclusion, these results demonstrate that MPO deficiency ameliorates renal injury in the renal ablation model of CKD in mice.


2009 ◽  
Vol 29 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Makio Nagano ◽  
Kei Fukami ◽  
Sho-ichi Yamagishi ◽  
Seiji Ueda ◽  
Yusuke Kaida ◽  
...  

2019 ◽  
Vol 37 ◽  
pp. e224
Author(s):  
S. Stabouli ◽  
O. Maliachova ◽  
N. Printza ◽  
A. Chainoglou ◽  
A. Christoforidis ◽  
...  

2009 ◽  
Vol 84 (3) ◽  
pp. 494-504 ◽  
Author(s):  
Ada W.Y. Chung ◽  
H.H. Clarice Yang ◽  
Mhairi K. Sigrist ◽  
Genevieve Brin ◽  
Elliott Chum ◽  
...  

Author(s):  
Nóra Kovács ◽  
Attila Nagy ◽  
Viktor Dombrádi ◽  
Klára Bíró

The prevalence of type 2 diabetes mellitus (T2DM) and the burden of complications are increasing worldwide. Chronic kidney disease (CKD) is one serious complication. Our aim was to investigate the trends and inequalities of the burden of CKD due to T2DM between 1990 and 2019. Data were obtained from the Global Health Data Exchange database. Age-standardized incidence, mortality, and DALYs rates of CKD were used to estimate the disease burden across the Human Development Index (HDI). Joinpoint regression was performed to assess changes in trend, and the Gini coefficient was used to assess health inequality. A higher incidence was observed in more developed countries (p < 0.001), while higher mortality and DALYs rates were experienced in low and middle HDI countries in 2019 (p < 0.001). The trend of incidence has increased since 1990 (AAPC: 0.9–1.5%), while slight decrease was observed in low HDI countries in mortality (APC: −0.1%) and DALYs (APC: −0.2%). The Gini coefficients of CKD incidence decreased from 0.25 in 2006 to 0.23 in 2019. The socioeconomic development was associated with disease burden. Our findings indicate that awareness of complications should be improved in countries with high incidence, and cost-effective preventive, diagnostic, and therapeutic tools are necessary to implement in less developed regions.


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