Fibro-Osseous Lesion Presenting with Refractory Microcytic Hypochromic Anemia

Ossifying fibroma (OF) is a rare, benign, fibro-osseous lesion of the jawbone characterised by replacement of the normal bone with fibrous tissue. The fibrous tissue shows varying amount of calcified structures resembling bone and/or cementum. The central variant of OF is rare, and shows predilection for mandible among the jawbone. Although it is classified as fibro-osseous lesion, it clinically behaves as a benign tumour and can grow to large size, causing bony swelling and facial asymmetry. This paper reports a case of large central OF of mandible in a 40-year-old male patient. The lesion was treated by segmental resection of mandible. Reconstruction of the surgical defect was done using avascular fibula bone graft. Role of three-dimensional printing of jaw and its benefits in surgical planning and reconstruction are also highlighted.

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Impact of Subclinical Haemoproteus columbae Infection on Farmed Domestic Pigeons from Central Java (Yogyakarta), Indonesia, with Special Reference to Changes in the Hemogram

Pathogens ◽

10.3390/pathogens10040440 ◽

2021 ◽

Vol 10 (4) ◽

pp. 440

Author(s):

Imron Rosyadi ◽

Siti Isrina Oktavia Salasia ◽

Bayanzul Argamjav ◽

Hiroshi Sato

Keyword(s):

Chronic Phase ◽

Hypochromic Anemia ◽

Hemoglobin Concentration ◽

Columba Livia ◽

Nucleotide Sequencing ◽

Mean Corpuscular Hemoglobin ◽

Haemoproteus Columbae ◽

Central Java ◽

Mitochondrial Cytochrome B ◽

Domestic Pigeons

Pigeon haemoproteosis caused by Haemoproteus columbae (Apicomplexa: Haemosporida: Haemoproteidae) is globally prevalent in rock doves (Columba livia), although little is known regarding this disease in pigeons and doves in Indonesia. Blood samples of 35 farmed domestic pigeons (C. livia f. domestica) from four localities in Yogyakarta Special Region, Central Java, Indonesia, were collected from March to June, 2016, subjected to a hemogram, and analyzed for the presence of hemoprotozoan infections. Microscopic examination of blood smears revealed a prevalence of 62.5–100% of H. columbae at the four localities (n = 8–10 for each locality), and geometric means of 3.0–5.6% of erythrocytes were parasitized by young and mature gametocytes, suggesting that all infected pigeons were in the chronic phase of infection with repeated recurrences and/or reinfections. Nucleotide sequencing of mitochondrial cytochrome b gene (cytb) for haemosporidian species demonstrated the distribution of four major cytb lineages of H. columbae (mainly HAECOL1, accompanied by COLIV03, COQUI05, and CXNEA02 according to the MalAvi database). Hemogram analysis, involving the estimation of packed cell volume, erythrocyte counts, mean corpuscular volume, mean corpuscular hemoglobin concentration, and plasma protein and fibrinogen levels of 20 parasitized pigeons and five non-infected pigeons demonstrated significant macrocytic hypochromic anemia with hypoproteinemia and hyperfibrinogenemia in the infected pigeons. This study shows the profound impact of long-lasting subclinical pigeon haemoproteosis caused by H. columbae on the health of farmed domestic pigeons.

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Chronic Suppurative Osteomyelitis Associated with Benign Fibro-Osseous Lesion

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2014.07.249 ◽

2015 ◽

Vol 119 (3) ◽

pp. e159

Author(s):

Eduardo Da Campo Junqueira ◽

Eduardo Pereira Guimarães ◽

Marina Lara De Carli ◽

João Adolfo ◽

Costa Hanemann ◽

...

Keyword(s):

Osseous Lesion

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Fibro-Osseous Lesion with Calcified Spherules (Cementifying Fibromalike Lesion) of the Tibia

Ultrastructural Pathology ◽

10.3109/01913129309015399 ◽

1993 ◽

Vol 17 (1) ◽

pp. 25-34 ◽

Cited By ~ 15

Author(s):

Ctibor Povýšil ◽

Zdeněk Matějovský

Keyword(s):

Osseous Lesion

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beta-thalassemia intermedia in a Brazilian patient with - 101(C > T) and codon 39 (C > T) mutations

Sao Paulo Medical Journal ◽

10.1590/s1516-31802003000100007 ◽

2003 ◽

Vol 121 (1) ◽

pp. 28-30

Author(s):

Sylvia Morais de Sousa ◽

Letícia Khater ◽

Luís Antônio Peroni ◽

Karine Miranda ◽

Marcelo Jun Murai ◽

...

Keyword(s):

Clinical Course ◽

Globin Gene ◽

Fetal Hemoglobin ◽

Hypochromic Anemia ◽

Beta Thalassemia ◽

Beta Globin ◽

Thalassemia Intermedia ◽

Mean Cell Volume ◽

Molecular Alterations ◽

Brazilian Patient

CONTEXT: We verified molecular alterations in a 72-year-old Brazilian male patient with a clinical course of homozygous beta-thalassemia intermedia, who had undergone splenectomy and was surviving without regular blood transfusions. The blood cell count revealed microcytic and hypochromic anemia (hemoglobin = 6.5 g/dl, mean cell volume = 74 fl, mean cell hemoglobin = 24 pg) and hemoglobin electrophoresis showed fetal hemoglobin = 1.3%, hemoglobin A2 = 6.78% and hemoglobin A = 79.4%. OBJECTIVE: To identify mutations in a patient with the symptoms of beta-thalassemia intermedia. DESIGN: Molecular inquiry into the mutations possibly responsible for the clinical picture described. SETTING: The structural molecular biology and genetic engineering center of the Universidade Estadual de Campinas, Campinas, Brazil. PROCEDURES: DNA extraction was performed on the patient's blood samples. The polymerase chain reaction (PCR) was done using five specific primers that amplified exons and the promoter region of the beta globin gene. The samples were sequenced and then analyzed via computer programs. RESULTS: Two mutations that cause the disease were found: -101 (C > T) and codon 39 (C > T). CONCLUSIONS: This case represents the first description of 101 (C > T) mutation in a Brazilian population and it is associated with a benign clinical course.

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Unusual fibro-osseous lesion of the spinal cord with positive staining for glial fibrillary acidic protein and radiological progression: A case report

Human Pathology ◽

10.1016/0046-8177(94)90256-9 ◽

1994 ◽

Vol 25 (8) ◽

pp. 835-838 ◽

Cited By ~ 28

Author(s):

David M. Smith ◽

Allen D. Berry

Keyword(s):

Spinal Cord ◽

Case Report ◽

Glial Fibrillary Acidic Protein ◽

Acidic Protein ◽

Positive Staining ◽

Radiological Progression ◽

Osseous Lesion

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Gardner's syndrome with an unusual fibro-osseous lesion of the mandible

Oral Surgery Oral Medicine Oral Pathology ◽

10.1016/0030-4220(80)90066-3 ◽

1980 ◽

Vol 49 (6) ◽

pp. 477-486 ◽

Cited By ~ 7

Author(s):

Irwin A. Small ◽

Harvey Shandler ◽

Mujtaba Husain ◽

Haskell David

Keyword(s):

Gardner's Syndrome ◽

Gardner’S Syndrome ◽

Osseous Lesion

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Hemoglobin variants in southern China: results obtained during the measurement of glycated hemoglobin in a large population

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2020-0767 ◽

2021 ◽

Vol 59 (1) ◽

pp. 227-232

Author(s):

Anping Xu ◽

Weidong Chen ◽

Weijie Xie ◽

Yajun Wang ◽

Ling Ji

Keyword(s):

High Performance ◽

Southern China ◽

Hematological Parameters ◽

Large Population ◽

Hypochromic Anemia ◽

Molecular Characteristics ◽

Inherited Disorders ◽

Hematological Analysis ◽

Hemoglobin Variants ◽

Hb Variant

AbstractObjectivesHemoglobin (Hb) variant is one of the most common monogenic inherited disorders. We aimed to explore the prevalence and hematological and molecular characteristics of Hb variants in southern China.MethodsWe collected blood samples from all patients with suspected variants found during HbA1c measurement via a cation-exchange high-performance liquid chromatography system (Bio-Rad Variant II Turbo 2.0) or a capillary electrophoresis method (Sebia Capillarys). Hematological analysis, Sanger sequencing, and gap-PCR were performed for these samples.ResultsAmong the 311,024 patients tested, we found 1,074 Hb variant carriers, including 823 identified using Capillarys and 251 using Variant II Turbo 2.0, with a total carrier rate of 0.35%. We discovered 117 types of Hb variants (52 HBB, 47 HBA, and 18 HBD mutations) containing 18 new mutations. The most common variant found was Hb E, followed by Hb New York, Hb J-Bangkok, Hb Q-Thailand, Hb G-Coushatta, Hb G-Honolulu, Hb G-Taipei, and Hb Broomhill. Most heterozygotes for the Hb variant exhibited normal hematological parameters. However, most patients with compound heterozygotes for the Hb variant and thalassemia showed varied degrees of microcytic hypochromic anemia.ConclusionsThe prevalence of hemoglobin variants remains high and exhibits genetic diversity and widespread distribution in the population of southern China.

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