Innovative Parameters RET-Y, sTfR, and sTfR-F Index in Patients with Microcytic, Hypochromic Anemia—Their Special Value for Hemoglobinopathies

2007 ◽  
Vol 13 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Athanasia Agorasti ◽  
Theodore Trivellas ◽  
Vassilios Papadopoulos ◽  
Despina Konstantinidou
2018 ◽  
Vol 64 (3) ◽  
pp. 335-344
Author(s):  
Aleksey Karachun ◽  
Yuriy Pelipas ◽  
Oleg Tkachenko ◽  
D. Asadchaya

The concept of biopsy of sentinel lymph node as the first lymph node in the pathway of lymphogenous tumor spread has been actively discussed over the past decades and has already taken its rightful place in breast and melanoma surgery. The goal of this method is to exclude vain lymphadenectomy in patients without solid tumor metastases in regional lymph nodes. In the era of minimally invasive and organ-saving operations interventions it seems obvious an idea to introduce a biopsy of sentinel lymph node in surgery of early gastric cancer. Meanwhile the complexity of lymphatic system of the stomach and the presence of so-called skip metastases are factors limiting the introduction of a biopsy of sentinel lymph node in stomach cancer. This article presents a systematic analysis of biopsy technology of signaling lymph node as well as its safety and oncological adequacy. Based on literature data it seems to us that the special value of biopsy of sentinel lymph nodes in the future will be in the selection of personalized surgical tactics for stomach cancer.


Author(s):  
A.V. Zhigunov ◽  
◽  
Q.T. Nguyen

The increasing need for herbal medicines requires the study of not only biological resources of medical plants, but also methods for their reproduction. Of special value are the medicinal plants that have a long history of success in traditional medicine. One of such plants is Eucommia ulmoides Oliv., which belongs to a rare relict species growing in natural conditions, for the most part, in the undergrowth of humid subtropical forests in China, mainly in the middle course of the Yangtze river. E. ulmoides compares favorably with most subtropical plants owing to its significant frost resistance, which makes it possible to cultivate it outside the humid subtropics. It has been widely introduced in Krasnodar Krai and in the Republic of Adygea (Russia) since the mid-20th century and successfully adapted to various environmental conditions in the Northwest Caucasus. The increasing demand for E. ulmoides bark can only be satisfied by laying out industrial plantations. However, the difficulties encountered in the traditional seed reproduction of E. ulmoides (dioecious species, pollen low quality, parthenocarpy, prolonged seed dormancy, irregular fruiting, long juvenile period, etc.) make scientists turn to modern biotechnological methods of plant propagation. While considering cultivation of planting material, we should focus on highly efficient methods that ensure stable and mass reproduction of the plants under study. An important role is played here by in vitro plant regeneration. The effectiveness of biotechnology methods is due to a reduction in timing of obtaining a large number of vegetative progeny of plants difficult for propagation, as well saving of the area required for their cultivation. The conditions for producing an aseptic culture of E. ulmoides were chosen based on the results of the studies. The highest degree of sterilization of E. ulmoides shoot segments was achieved when the explants were sequentially immersed first in 70 % ethanol (30 s) and then in 0.1 % mercuric chloride solution (5 min). With such a sterilization procedure, 63.3 % of the studied cuttings were made sterile, and 56.7 % of them proved to be viable. The optimal composition of the nutrient medium for regeneration of E. ulmoides microshoots has been determined: MS medium complemented with 1 mg/L 6-Benzylaminopurine (BAP) + 0.2 mg/L 1-Naphthaleneacetic acid (NAA). The best media for explant rooting are the following: 2/3 MS + 1.5 mg/L NAA + 30 g sucrose + 7 g agar; 2/3 MS + 1 mg/L NAA + 0.4 mg/L IBA + 30 g sucrose + 7 g agar.


Author(s):  
V. J Manzo

In Max/MSP/Jitter for Music, expert author and music technologist V. J. Manzo provides a user-friendly introduction to a powerful programming language that can be used to write custom software for musical interaction. Through clear, step-by-step instructions illustrated with numerous examples of working systems, the book equips you with everything you need to know in order to design and complete meaningful music projects. The book also discusses ways to interact with software beyond the mouse and keyboard through use of camera tracking, pitch tracking, video game controllers, sensors, mobile devices, and more. This book will be of special value for everyone who teaches music at any level, from classroom instructors to ensemble directors to private studio instructors. Whether you want to create simple exercises for beginning performers or more complex programs for aspiring composers, this book will show you how to write customized software that can complement and even inspire your instructional objectives. No specialist foreknowledge is required to use this book to enliven your experience with music technology. Even musicians with no prior programming skills can learn to supplement their lessons with interactive instructional tools, to develop adaptive instruments to aid in composition and performance activities, and to create measurement tools with which to conduct research. This book allows you to: -Learn how to design meaningful projects for composition, performance, music therapy, instruction, and research -Understand powerful software through this accessible introduction, written for beginners -Follow along through step-by-step tutorials -Grasp the principles by downloading the extensive software examples from the companion website This book is ideal for: -Music educators at all levels looking to integrate software in instruction -Musicians interested in how software can improve their practice and performance -Music composers with an interest in designing interactive music -Music therapists looking to tailor programs to the needs of specific groups or individuals And all who are interested in music technology. Visit the companion website at www.oup.com/us/maxmspjitter


2021 ◽  
Vol 2021 (7) ◽  
Author(s):  
Andrés Anabalón ◽  
Simon F. Ross

Abstract We study Lorentzian supersymmetric configurations in D = 4 and D = 5 gauged $$ \mathcal{N} $$ N = 2 supergravity. We show that there are smooth 1/2 BPS solutions which are asymptotically AdS4 and AdS5 with a planar boundary, a compact spacelike direction and with a Wilson line on that circle. There are solitons where the S1 shrinks smoothly to zero in the interior, with a magnetic flux through the circle determined by the Wilson line, which are AdS analogues of the Melvin fluxtube. There is also a solution with a constant gauge field, which is pure AdS. Both solutions preserve half of the supersymmetries at a special value of the Wilson line. There is a phase transition between these two saddle-points as a function of the Wilson line precisely at the supersymmetric point. Thus, the supersymmetric solutions are degenerate, at least at the supergravity level. We extend this discussion to one of the Romans solutions in four dimensions when the Euclidean boundary is S1× Σg where Σg is a Riemann surface with genus g > 0. We speculate that the supersymmetric state of the CFT on the boundary is dual to a superposition of the two degenerate geometries.


Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 440
Author(s):  
Imron Rosyadi ◽  
Siti Isrina Oktavia Salasia ◽  
Bayanzul Argamjav ◽  
Hiroshi Sato

Pigeon haemoproteosis caused by Haemoproteus columbae (Apicomplexa: Haemosporida: Haemoproteidae) is globally prevalent in rock doves (Columba livia), although little is known regarding this disease in pigeons and doves in Indonesia. Blood samples of 35 farmed domestic pigeons (C. livia f. domestica) from four localities in Yogyakarta Special Region, Central Java, Indonesia, were collected from March to June, 2016, subjected to a hemogram, and analyzed for the presence of hemoprotozoan infections. Microscopic examination of blood smears revealed a prevalence of 62.5–100% of H. columbae at the four localities (n = 8–10 for each locality), and geometric means of 3.0–5.6% of erythrocytes were parasitized by young and mature gametocytes, suggesting that all infected pigeons were in the chronic phase of infection with repeated recurrences and/or reinfections. Nucleotide sequencing of mitochondrial cytochrome b gene (cytb) for haemosporidian species demonstrated the distribution of four major cytb lineages of H. columbae (mainly HAECOL1, accompanied by COLIV03, COQUI05, and CXNEA02 according to the MalAvi database). Hemogram analysis, involving the estimation of packed cell volume, erythrocyte counts, mean corpuscular volume, mean corpuscular hemoglobin concentration, and plasma protein and fibrinogen levels of 20 parasitized pigeons and five non-infected pigeons demonstrated significant macrocytic hypochromic anemia with hypoproteinemia and hyperfibrinogenemia in the infected pigeons. This study shows the profound impact of long-lasting subclinical pigeon haemoproteosis caused by H. columbae on the health of farmed domestic pigeons.


2003 ◽  
Vol 121 (1) ◽  
pp. 28-30
Author(s):  
Sylvia Morais de Sousa ◽  
Letícia Khater ◽  
Luís Antônio Peroni ◽  
Karine Miranda ◽  
Marcelo Jun Murai ◽  
...  

CONTEXT: We verified molecular alterations in a 72-year-old Brazilian male patient with a clinical course of homozygous beta-thalassemia intermedia, who had undergone splenectomy and was surviving without regular blood transfusions. The blood cell count revealed microcytic and hypochromic anemia (hemoglobin = 6.5 g/dl, mean cell volume = 74 fl, mean cell hemoglobin = 24 pg) and hemoglobin electrophoresis showed fetal hemoglobin = 1.3%, hemoglobin A2 = 6.78% and hemoglobin A = 79.4%. OBJECTIVE: To identify mutations in a patient with the symptoms of beta-thalassemia intermedia. DESIGN: Molecular inquiry into the mutations possibly responsible for the clinical picture described. SETTING: The structural molecular biology and genetic engineering center of the Universidade Estadual de Campinas, Campinas, Brazil. PROCEDURES: DNA extraction was performed on the patient's blood samples. The polymerase chain reaction (PCR) was done using five specific primers that amplified exons and the promoter region of the beta globin gene. The samples were sequenced and then analyzed via computer programs. RESULTS: Two mutations that cause the disease were found: -101 (C > T) and codon 39 (C > T). CONCLUSIONS: This case represents the first description of 101 (C > T) mutation in a Brazilian population and it is associated with a benign clinical course.


2016 ◽  
Vol 22 (1) ◽  
pp. 46-58 ◽  
Author(s):  
Liat Shani

Animal-assisted psychotherapy (AAP) inherently incorporates standpoints, interventions, and ways of action promoting the development of the reflective function and mentalization, and thus has special value for parent–child psychotherapy. Two central tools in AAP contribute to this process. The first is the ethical stance of the therapist, who sees the animals as full partners in the therapy situation, respecting them as subjects with needs, desires, and thoughts of their own. The second tool combines nonverbal communication with animals together with the relating, in the here and now, to the understanding and decoding of body language of everyone in the setting. Nonverbal communication in AAP enables access to implicit communication patterns occurring between parent and child. This article provides a survey of theoretical development and research constituting a basis for the development of therapeutic approaches for the improvement of parent–children dynamics, followed by a description of a dyadic therapy model of a mentalization-based treatment originating from a psychoanalytic-relational orientation. Clinical examples are provided to illustrate AAP processes in parent–child psychotherapy (consent was received for examples that were not aggregated).


1863 ◽  
Vol 153 ◽  
pp. 617-648 ◽  

1. In a paper which the Royal Society have printed in their Philosophical Transactions for 1862, I gave a series of curves exhibiting to the eye the diurnal inequalities of Terrestrial Magnetism in the three directions of Westerly Force, Northerly Force, and Nadir Force, as inferred from eye-observations and photographic registers at the Royal Obser­vatory from 1841 to 1857. The paper, or the works to which it refers, exhibits also the secular change and the annual inequality through that period, and the lunar inequalities as inferred from the period 1848 to 1857. These results were obtained by excluding the observations of certain days (of whch a list was given) on which the motions of the magnetometers were so violent that it was difficult to draw a mean curve through the magnetic curve of the day. In the present paper I propose to give the principal results deducible from the days omitted in the former paper. But before entering into the details of the numerical investigations, I think it desirable to explain the principles upon which both parts of the investigations have been conducted. 2. The methods commonly employed in late years for measuring and classifying the effects of magnetic disturbance have been, in my judgment, very valuable to the science, especially in its earlier stages. But familiarity through many past years with magnetic photograms has strongly impressed me with the feeling that a different method ought now to be employed, taking account of relations of disturbances which perhaps could not be known at the introduction of the ancient method. I may thus describe the general ideas which have guided me:—First, that there is no such thing as a day really free from disturbance, and no reason in the nature of things for separating one or more days from the general series. There is abundant reason for such separation on the ground of convenience of reduction; but when the reduction has been effected by suit­able process, the results of the separated days ought to be combined with those of the unseparated days in the formation of general means (the numerical necessity for which I propose to consider in the close of this paper),—the reduction of the separated days serving also to throw great light upon the nature of the acting forces on those days, which forces in all probability are acting, though in different degrees, on other days. Second, that, with our present knowledge of the character of magnetic disturbances, I cannot think myself justified in separating any single magnetic indication, or any series of indications defined only by their magnitude; nor do I entertain the belief that any special value could attach to the results which I might derive from observations from which such indications have been removed. The study of the photograms shows clearly that the successive indications at successive moments of the same day are a connected series; there is no such thing as a sudden display of force in any element; the sharpest salience which is exhibited on a generally smooth curve occupies at least an hour in its development (I believe, never less, although the individual saliences in a continued storm are of shorter duration), and during this time the force has been gradually increasing and gradually diminishing. Under these circumstances, I cannot think it right that I should cut off a part of that salienee, with the belief of obtaining results, that can possess any philosophical value, from the part which is left. And I come to the conclusion that each disturbed day must be considered in its entirety, and that our attention ought to be given in the first instance to the devising of methods by which the complicated registers of each of those days, separately considered, can be rendered manageable, and in the next place to the discussion of the laws of disturbance which they may aid to reveal to us, and to the ascertaining of their effects on the general means in which they ought to be included.


2004 ◽  
Vol 18 (31n32) ◽  
pp. 4129-4142 ◽  
Author(s):  
H. EZ-ZAHRAOUY ◽  
H. MAHBOUB ◽  
A. BENYOUSSEF ◽  
M. J. OUAZZANI

The effect of the random quantum transverse field Ω on the tricritical behavior of the spin-1 Blume–Emery–Griffiths (BEG) model is studied using an effective field theory. It is found that the tricritical behavior depends on both the biquadratic interaction K, single-ion anisotropy Δ and the concentration p of the disorder of Ω. Indeed, there exists a special value p1 of the probability p below which the tricritical behavior disappears. In addition, at sufficiently low temperatures, the system exhibits long-range order accompanied by the tricritical behavior below a special value p2 of the probability p.


2021 ◽  
Vol 59 (1) ◽  
pp. 227-232
Author(s):  
Anping Xu ◽  
Weidong Chen ◽  
Weijie Xie ◽  
Yajun Wang ◽  
Ling Ji

AbstractObjectivesHemoglobin (Hb) variant is one of the most common monogenic inherited disorders. We aimed to explore the prevalence and hematological and molecular characteristics of Hb variants in southern China.MethodsWe collected blood samples from all patients with suspected variants found during HbA1c measurement via a cation-exchange high-performance liquid chromatography system (Bio-Rad Variant II Turbo 2.0) or a capillary electrophoresis method (Sebia Capillarys). Hematological analysis, Sanger sequencing, and gap-PCR were performed for these samples.ResultsAmong the 311,024 patients tested, we found 1,074 Hb variant carriers, including 823 identified using Capillarys and 251 using Variant II Turbo 2.0, with a total carrier rate of 0.35%. We discovered 117 types of Hb variants (52 HBB, 47 HBA, and 18 HBD mutations) containing 18 new mutations. The most common variant found was Hb E, followed by Hb New York, Hb J-Bangkok, Hb Q-Thailand, Hb G-Coushatta, Hb G-Honolulu, Hb G-Taipei, and Hb Broomhill. Most heterozygotes for the Hb variant exhibited normal hematological parameters. However, most patients with compound heterozygotes for the Hb variant and thalassemia showed varied degrees of microcytic hypochromic anemia.ConclusionsThe prevalence of hemoglobin variants remains high and exhibits genetic diversity and widespread distribution in the population of southern China.


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