Conclusion
This chapter focuses on the evidence-based medicine (EBM) reform project. Ultimately, if the EBM project is to realize its aspirational goal to improve the quality and efficiency of U.S. medical care, it is necessary but insufficient for research agencies like Patient-Centered Outcomes Research Institute (PCORI) to endure. In the long run, patterns of medical governance must change. PCORI (or whatever entity succeeds it) must develop a reputation among key stakeholders for competence, relevance, and impact that causes policy makers to conclude that supporting EBM is in their own political interest. The chapter then draws on lessons from the literature on U.S. state building to develop strategies to increase the durability of medical governance reform in contemporary American politics. It also briefly reviews the challenges of political sustainability that face any new agency or policy.