scholarly journals Features of thrombocyte-vascular hemostasis in women with abnormal uterine bleeding and submucosal uterine fibroids

2021 ◽  
Vol 25 (2(98)) ◽  
pp. 9-12
Author(s):  
I. Byrchak ◽  
S. Yasnikovska ◽  
A. Goshovska
Keyword(s):  
Uterine Fibroids ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Aggregate State ◽  
Severe Degree ◽  
Fibrinolytic Potential

Objective – to investigate the features of platelet-vascular hemostasis in women with abnormal uterine bleeding on the background of submucosal uterine fibroids.Material and methods. The study included 30 women with abnormal uterine bleeding with submucosal uterine fibroids. Features of thrombocyte-vascular hemostasis were studiedResults. There are new data in relation to the features of certain links of the adjusting system of the aggregate state of blood on a background development of post hemorrhage anaemia. It is clearly shown that changes in the system of adjusting of the aggregate state of blood in women with a severe degree of anaemisation are the display of subclinical inopexi.Conclusions. Changes in the fibrinolytic potential of blood in women with chronic posthemorrhagic anemia on the background of abnormal uterine bleeding and submucosal uterine fibroids are secondary, due to the activation of thrombin and fibrinogenesis by external mechanisms.

scholarly journals Demographic parameters of women with uterine fibroids presenting as abnormal uterine bleeding

2018 ◽  
Vol 7 (7) ◽  
pp. 2915
Author(s):  
Manjiri R. Podder ◽  
Rahul Podder ◽  
Poonam V. Shivkumar
Keyword(s):  
Uterine Fibroids ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Reproductive Age ◽  
Uterine Tumors ◽  
Perimenopausal Women ◽  
Diagnostic Modalities ◽  
Pelvic Pressure ◽  
Reproductive Age Group ◽  
Demographic Features

Background: Uterine fibroids are commonest benign uterine tumors. Only about 25% women with fibroids are symptomatic. Around 70-80% are discovered incidentally during routine pelvic examination. Using ultrasonography screening, some authors have estimated a cumulative incidence of 70% in all women by age 50. Symptoms attributable to fibroids are mainly abnormal uterine bleeding (AUB), pelvic pressure, pain, and reproductive dysfunction. Heavy and/or prolonged menses is the typical bleeding pattern with myomas. Uterine fibroids are a leading cause of hysterectomy in perimenopausal women, thus, this study was done to find out its prevalence and demography in women presenting with AUB. The objectives of the present investigation were to find out the prevalence of uterine fibroid in women with AUB and to find out the various demographic features of womenMethods: The study was done for 2 years in the Dept of Obstetrics and Gynecology of a rural tertiary institute after taking clearance from institutional ethical committee. All the women presenting with AUB were included in the study. History and demographic features was enquired and entered in a predesigned proforma. All women were clinically examined after consent. Women with suspicion of fibroid were subjected to diagnostic modalities and the reports were followed and correlated.Results: Total 11,841 patients came to Gynaeological OPD during the study period. Out of these 3,878 (32.75%) presented with AUB, 2,126 were diagnosed as having fibroids after examination and investigations. Hence, the prevalence of fibroids amongst the women with AUB was 54.82% and 17.95% amongst all gynaecological patients. Maximum women were between 31-40 years, (64.78% rural and 62.73% urban). Majority were having parity between 1-2 (40.73% in urban, 38.96% in rural).Conclusions: Uterine fibroids are the commonest reason of AUB in reproductive age group with the prevalence of 54.82%. The trends in age incidence have remained the same over the years, commonly affecting women in third decade. There is no difference in incidence of fibroids amongst various socioeconomic classes. 

Combined Oral Contraceptive for Treatment of Women with Uterine Fibroids and Abnormal Uterine Bleeding: A Systematic Review

2015 ◽  
Vol 79 (3) ◽  
pp. 145-152 ◽  
Author(s):  
Rafael M. Moroni ◽  
Wellington P. Martins ◽  
Sabrine V. Dias ◽  
Carolina S. Vieira ◽  
Rui A. Ferriani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Contraceptive ◽  
Uterine Fibroids ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Combined Oral Contraceptive

scholarly journals Neglected case of uterine leiomyoma: Case report

2008 ◽  
Vol 61 (9-10) ◽  
pp. 525-528
Author(s):  
Dejan Nincic ◽  
Aljosa Mandic ◽  
Dragan Zikic ◽  
Bratislav Stojiljkovic ◽  
Katarina Mastilovic ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Clinical Laboratory ◽  
Uterine Fibroids ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Imaging Evaluation ◽  
Abdominal Tumor ◽  
Adequate Treatment ◽  
Good General Condition

Introduction. Uterine leimyomas are the most common gynaecologacal tumors and represent 30% of all benign gynecological tumors. The vast majority of leiomyomas are asymptomatic and do not need to be treated. Pelvic pain and abnormal uterine bleeding should be considered as the most important reasons for surgical treatment of uterine fibroids. Case report. A female patient, age 69, was treated at the Institute of Oncology in Sremska Kamenica because of a huge abdominal tumor. Major symptoms were increased body temperature, abnormal uterine bleeding and extensive abdominal enlargement. After the clinical, laboratory and imaging evaluation, the offered hysterectomy was performed. The evacuated tumor was 18 kg heavy and 40 cm in length. The pathohystological diagnosis was leiomyoma per magnum. The patient was released after 11 days of hospitalization without any postoperative complications and in good general condition. Discussion. Uterine fibroids can be managed medically and surgically. Hysterectomy should be performed in every case with dominant symptoms like abnormal uterine bleeding, tumor growth and increasing abdominal pain (when other causes are excluded) in postmenopausal women. This particular case is an example of low general and health culture of the reported patient and maybe caused by fear from medical and surgical treatment. Sometimes, making a diagnosis of the nature of pelvic tumor is very hard, but by respecting diagnostic procedure an adequate treatment of those patients can be ensured.

scholarly journals Characteristics of Violations in the Aggregate State of Blood Regulation System of Women with a High Degree Anemia on the Background of Endometrium Hyperplastic Processes

2018 ◽  
Vol 25 (1) ◽  
Author(s):  
Inna Byrchak
Keyword(s):  
Blood Plasma ◽  
Endometrial Hyperplasia ◽  
Uterine Bleeding ◽  
Regulation System ◽  
Aggregate State ◽  
Primary Hemostasis ◽  
Total Potential ◽  
Uterine Mucosa ◽  
Severe Degree ◽  
Spontaneous Platelet Aggregation

Endometrial hyperplasia is a benign pathology of the uterine mucosa, characterized by certain histological changes, characterized as simple and complex, non-atypical and atypical forms. Hyperplastic processes of endometrium, according to various authors, in the structure of gynecological pathology make up 15 to 40%. Clinically, the endometrial hyperplasia manifest by uterine bleeding. Maternal bleeding that is not susceptible to hormonal, symptomatic, and hemostatic therapy, leads to chronic post-hemorrhagic anemia and is the indication for surgical intervention. Consequently, systemic disorders of the hemostasis parameters on the background of uterine bleeding with endometrial hyperplasia, in particular the regulation of the aggregate state of blood systems, require further research to identify new pathogenetic links and develop correction methods.Materials and methods.State of platelet-vascular hemostasis was assessed by the percentage of platelets adhesion in the blood and by the index of spontaneous platelet aggregation. Total potential coagulation of blood, plasma fibrinolytic activity, plasminogen potential activity, antiplasmin, fibrinogen in blood plasma, the activity of antithrombin III, the concentration of soluble fibrin monomer complexes in the blood was determined by reagents made by Simko Ltd company (Ukraine). Using the «Thromboelastohraph ACG» machine we identified parameters of thrombin clotting rate, thromboelastograph K constant, specific platelets convolution constants, a- angle and coagulation composite index.Results. In women with anemia of ІІІ-rd degree against background of the uterine bleeding, at high activity of primary hemostasis, structural and chronometric hypocoagulation develops; it is predefined by the acute decreasing of fibrinogen in the blood. The principal reason of hypofibrinogenaemia is the excessive activating of non-fermentative fibrinolysis. In conclusion, changes in the system of regulation of the aggregate state of blood in women with severe degree of anemia are the display of subclinical inopexia that develops as a result of thrombocytes high functional activity.

scholarly journals LEVONORGESTREL INTRAUTERINE DEVICE VERSUS MEDROXYPROGESTERONE ACETATE IN TREATMENT OF SYMPTOMATIC UTERINE FIBROIDS

2018 ◽  
Vol 6 (7) ◽  
pp. 341-347
Author(s):  
Uğurkan Erkayıran ◽  
Bülent Köstü ◽  
Alev Özer ◽  
Abdullah Tok ◽  
Selim Karaküçük
Keyword(s):  
Pelvic Pain ◽  
Medroxyprogesterone Acetate ◽  
Intrauterine Device ◽  
Uterine Fibroids ◽  
Abnormal Uterine Bleeding ◽  
Good Choice ◽  
Uterine Bleeding ◽  
Number Of Patients ◽  
One Year ◽  
The One

Background: Medroxyprogesterone acetate (MPA) and levonorgestrel intrauterine device (LNG-IUD) are two drugs used to treat abnormal uterine bleeding in women with myoma. We organized this study to compare the effectiveness of these two treatments. Methods: This was a retrospective one-year-long cohort study of 95 women with uterine leimyoma. Fifty three women who had received LNG-IUD formed the LNG-IUD group while 42 women who received regular intramuscular injections of 150 mg MPA at every 3 months for one-year period made up the MPA group. Both groups were compared in aspect of demographic, clinical and biochemical characteristics. Results: At the end of one year, the LNG-IUD group had significantly smaller fibroid size, lower visual analogus scale score for pelvic pain, for dysmenorrhea and dyspareunia than the MPA group. There were a significant reduction in the number of patients with menorrhagia and a significant increase in serum hemoglobine levels both in  LNG-IUD and MPA groups at the end of the one-year long study period. Conclusions: LNG-IUD appears as a good choice for the reduction in fibroid size and associated pelvic pain.

scholarly journals Transvaginal Ultrasonography and Saline Infusion Sonohysterography for the Detection of Intra-Uterine Lesions in Pre- and Post-Menopausal Women with Abnormal Uterine Bleeding

2008 ◽  
Vol 36 (6) ◽  
pp. 1205-1213 ◽  
Author(s):  
B Yildizhan ◽  
R Yildizhan ◽  
B Ozkesici ◽  
N Suer
Keyword(s):  
Sensitivity And Specificity ◽  
Uterine Fibroids ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Saline Infusion ◽  
Transvaginal Ultrasonography ◽  
Endometrial Polyps ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Saline Infusion Sonohysterography

This prospective study investigated 79 pre- and 25 post-menopausal women with abnormal uterine bleeding who underwent conventional transvaginal ultrasonography (TVS) and saline infusion sonohysterography (SIS) and compared the results with histopathological findings obtained by dilatation and curettage, hysteroscopy or hysterectomy. Histological examination revealed normal endometrial histology in 28 patients, intracavitary polyps in 46 patients, submucosal fibroids in 18 patients, intramural fibroids in six patients and endometrial hyperplasia in six patients. The sensitivity and specificity of TVS in detecting endometrial polyps were 65.2% and 87.9%, respectively, compared with 91.3% and 93.1% for SIS. The sensitivity and specificity of TVS in detecting uterine fibroids were 95.8% and 95.0%, respectively, versus 91.6% and 98.7% for SIS. These results show that SIS is a satisfactory method of identifying lesions and that it is easy and cost-effective, and improves on the diagnostic utility of TVS. SIS is also a less invasive alternative to hysteroscopy, so should result in less morbidity in the evaluation of abnormal uterine bleeding in women.

Uterine Fibroids

2021 ◽  
Author(s):  
Kari Plewniak ◽  
Hye-Chun Hur
Keyword(s):  
Key Words ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Hormonal Status ◽  
Artery Embolization ◽  
Medical Comorbidities

Uterine fibroids may be present in up to 80% of women and are the most common benign indication for hysterectomy. Symptoms related to fibroids can vary tremendously and depend on the number, size, and location of fibroids, as well as the patient’s hormonal status. Several different treatment options are available for fibroids. A variety of factors, such as a patient’s symptoms, age, reproductive goals, and medical comorbidities, help determine which treatment is best for each patient.  This review contains 11 figures, 4 tables and 55 references Key Words: abnormal uterine bleeding, fibroids, FIGO fibroid classification, hysterectomy, leiomyoma, myomectomy, uterine artery embolization

scholarly journals Characteristics of Violations in the Aggregate State of Blood Regulation System of Women with a High Degree Anemia on the Background of Endometrium Hyperplastic Processes

2018 ◽  
Vol 25 (1) ◽  
Author(s):  
Inna Byrchak
Keyword(s):  
Blood Plasma ◽  
Endometrial Hyperplasia ◽  
Uterine Bleeding ◽  
Regulation System ◽  
Aggregate State ◽  
Primary Hemostasis ◽  
Total Potential ◽  
Uterine Mucosa ◽  
Severe Degree ◽  
Spontaneous Platelet Aggregation

Endometrial hyperplasia is a benign pathology of the uterine mucosa, characterized by certain histological changes, characterized as simple and complex, non-atypical and atypical forms. Hyperplastic processes of endometrium, according to various authors, in the structure of gynecological pathology make up 15 to 40%. Clinically, the endometrial hyperplasia manifest by uterine bleeding. Maternal bleeding that is not susceptible to hormonal, symptomatic, and hemostatic therapy, leads to chronic post-hemorrhagic anemia and is the indication for surgical intervention. Consequently, systemic disorders of the hemostasis parameters on the background of uterine bleeding with endometrial hyperplasia, in particular the regulation of the aggregate state of blood systems, require further research to identify new pathogenetic links and develop correction methods.Materials and methods.State of platelet-vascular hemostasis was assessed by the percentage of platelets adhesion in the blood and by the index of spontaneous platelet aggregation. Total potential coagulation of blood, plasma fibrinolytic activity, plasminogen potential activity, antiplasmin, fibrinogen in blood plasma, the activity of antithrombin III, the concentration of soluble fibrin monomer complexes in the blood was determined by reagents made by Simko Ltd company (Ukraine). Using the «Thromboelastohraph ACG» machine we identified parameters of thrombin clotting rate, thromboelastograph K constant, specific platelets convolution constants, a- angle and coagulation composite index.Results. In women with anemia of ІІІ-rd degree against background of the uterine bleeding, at high activity of primary hemostasis, structural and chronometric hypocoagulation develops; it is predefined by the acute decreasing of fibrinogen in the blood. The principal reason of hypofibrinogenaemia is the excessive activating of non-fermentative fibrinolysis. In conclusion, changes in the system of regulation of the aggregate state of blood in women with severe degree of anemia are the display of subclinical inopexia that develops as a result of thrombocytes high functional activity.

Sign in / Sign up

Export Citation Format

Share Document