scholarly journals Uncertain model of industrial clusters for the optimal arrangement of co-operation networks under sustainable and dynamic conditions

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Abbas Sarafrazi ◽  
Reza Tavakkoli-Moghaddam ◽  
Mahdi Bashiri ◽  
Gholamreza Esmaeilian
Keyword(s):  
Industrial Clusters ◽  
Optimal Arrangement ◽  
Dynamic Conditions ◽  
Uncertain Model

Neutrophil Derived Cathepsin G Induces Potentially Thrombogenic Changes in Human Endothelial Cells: a Scanning Electron Microscopy Study in Static and Dynamic Conditions

1994 ◽  
Vol 72 (01) ◽  
pp. 140-145 ◽  
Author(s):  
Valeri Kolpakov ◽  
Maria Cristina D'Adamo ◽  
Lorena Salvatore ◽  
Concetta Amore ◽  
Alexander Mironov ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Thrombus Formation ◽  
Cathepsin G ◽  
Arterial Segment ◽  
Dynamic Conditions ◽  
Activated Neutrophils ◽  
Scanning Electron

SummaryActivated neutrophils may promote thrombus formation by releasing proteases which may activate platelets, impair the fibrinolytic balance and injure the endothelial monolayer.We have investigated the morphological correlates of damage induced by activated neutrophils on the vascular wall, in particular the vascular injury induced by released cathepsin G in both static and dynamic conditions.Human umbilical vein endothelial cells were studied both in a cell culture system and in a model of perfused umbilical veins. At scanning electron microscopy, progressive alterations of the cell monolayer resulted in cell contraction, disruption of the intercellular contacts, formation of gaps and cell detachment.Contraction was associated with shape change of the endothelial cells, that appeared star-like, while the underlying extracellular matrix, a potentially thrombogenic surface, was exposed. Comparable cellular response was observed in an “in vivo” model of perfused rat arterial segment. Interestingly, cathepsin G was active at lower concentrations in perfused vessels than in culture systems. Restoration of blood flow in the arterial segment previously damaged by cathepsin G caused adhesion and spreading of platelets on the surface of the exposed extracellular matrix. The subsequent deposition of a fibrin network among adherent platelets, could be at least partially ascribed to the inhibition by cathepsin G of the vascular fibrinolytic potential.This study supports the suggestion that the release of cathepsin G by activated neutrophils, f.i. during inflammation, may contribute to thrombus formation by inducing extensive vascular damage.

Industrial Clusters: a New Idea or an Old One?

1999 ◽  
Vol 29 (First Serie (1) ◽  
pp. 73-77 ◽  
Author(s):  
Gavin McCrone
Keyword(s):  
Industrial Clusters

Industrial Clusters: Scotland's Route to Economic Success

1999 ◽  
Vol 29 (First Serie (1) ◽  
pp. 43-58 ◽  
Author(s):  
Ron Botham ◽  
Bob Downes
Keyword(s):  
Industrial Clusters ◽  
Economic Success

Stochastic optimization of economic, financial, information, and logistics inter-cluster cooperation

2020 ◽  
Vol 26 (9) ◽  
pp. 1928-1950
Author(s):  
S.N. Yashin ◽  
Yu.V. Trifonov ◽  
E.V. Koshelev
Keyword(s):  
Public Policy ◽  
Population Growth ◽  
Stochastic Optimization ◽  
Optimization Model ◽  
Federal District ◽  
Industrial Clusters ◽  
Financial Information ◽  
Policy Management ◽  
Federal Districts ◽  
Further Development

Subject. This article deals with the simulation technologies based on the principles of stochastic optimization. They can bring a significant financial effect in the planning of investment development of both individual innovation and industrial clusters and federal districts of the country. Objectives. The article aims to investigate the mechanisms of inter-cluster cooperation within a single district. Methods. For the analysis, we used a stochastic optimization model in view of economic, financial, information, and logistics inter-cluster cooperation within a single federal district. Results. The considered stochastic optimization model of economic, financial, information, and logistics inter-cluster cooperation shows that the increase in fixed investment does not always cause population growth in the federal district regions. Conclusions. The use of a digital twin mechanism of inter-cluster cooperation can help avoid premature unreasonable public policy management decisions regarding the further development of innovation and industrial clusters.

State Financial Support of Innovative Industrial Clusters

2019 ◽  
Author(s):  
A.V. Polyanin ◽  
L.I. Pronyayeva ◽  
A.V. Pavlova ◽  
O.A. Fedotenkova
Keyword(s):  
Financial Support ◽  
Industrial Clusters

Increase of Investment Appeal of the Regions by Formation of Special Economic Zones and Territorial-Industrial Clusters

2019 ◽  
pp. 94-98
Author(s):  
I.G. Parshutina ◽  
O.A. Shaporova ◽  
E.A. Kirpichenko ◽  
◽  
◽  
...  
Keyword(s):  
Industrial Clusters ◽  
Special Economic Zones ◽  
Economic Zones
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