scholarly journals GLYCATED HEMOGLOBIN A1C AS A BIOMARKER PREDICTOR FOR DIABETES MELLITUS, CARDIOVASCULAR DISEASE AND INFLAMMATION

2018 ◽  
Vol 23 (2) ◽  
pp. 191
Author(s):  
Indranila KS
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Hemoglobin A1c ◽  
Glycated Hemoglobin ◽  
Glycated Hemoglobin A1c ◽  
Diabetes Melitus

Hemoglobin glikasi (HbA1c) telah diakui secara luas sebagai petanda biologis peramal untuk keparahan Diabetes Melitus (DM).Hemoglobin glikosilasi (HbA1c) adalah petanda biologis penting yang mencerminkan kepekatan glukosa plasma puasa dan postprandialselama 120 hari sebelumnya. Telah dianggap sebagai alat penting dalam diagnosis dan manajemen diabetes. Peningkatan kadar HbA1cberarti resistensi insulin jangka panjang dan konsekuensi berat adanya hiperglikemia, dislipidemia, hiperkoagulabilitas dan responsinflamasi. Terdapat hubungan positif antara HbA1c tinggi dan hasil yang buruk pada DM, penyakit kardiovaskular (CVD) dan inflamasi.HbA1c adalah petanda biologis peramal tidak hanya di DM, tetapi juga untuk CVD dan inflamasi.

scholarly journals Glycated Hemoglobin A1c Levels in Type 1 Diabetes Mellitus and Outcomes After Myocardial Infarction

Circulation ◽  
2019 ◽  
Vol 139 (20) ◽  
pp. 2380-2382 ◽  
Author(s):  
Thomas Nyström ◽  
Ulrik Sartipy ◽  
Andrea Contardi ◽  
Marcus Lind ◽  
Rino Bellocco ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Hemoglobin A1c ◽  
Glycated Hemoglobin ◽  
Glycated Hemoglobin A1c

scholarly journals Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis

2020 ◽  
Vol 127 (7) ◽  
pp. 877-892 ◽  
Author(s):  
Michelle C. Flynn ◽  
Michael J. Kraakman ◽  
Christos Tikellis ◽  
Man K.S. Lee ◽  
Nordin M.J. Hanssen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Glucose Transporter ◽  
Hemoglobin A1c ◽  
Glycated Hemoglobin ◽  
Plasma Cholesterol ◽  
Wild Type ◽  
Glucose Transporter 1 ◽  
Glycation End Products ◽  
Viable Approach

Rationale: Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend >50% of their time outside the optimal glucose range. These glucose variations, termed transient intermittent hyperglycemia (TIH), appear to be an independent risk factor for cardiovascular disease, but the pathological basis for this association is unclear. Objective: To determine whether TIH per se promotes myelopoiesis to produce more monocytes and consequently adversely affects atherosclerosis. Methods and Results: To create a mouse model of TIH, we administered 4 bolus doses of glucose at 2-hour intervals intraperitoneally once to WT (wild type) or once weekly to atherosclerotic prone mice. TIH accelerated atherogenesis without an increase in plasma cholesterol, seen in traditional models of diabetes mellitus. TIH promoted myelopoiesis in the bone marrow, resulting in increased circulating monocytes, particularly the inflammatory Ly6-C hi subset, and neutrophils. Hematopoietic-restricted deletion of S100a9 , S100a8 , or its cognate receptor Rage prevented monocytosis. Mechanistically, glucose uptake via GLUT (glucose transporter)-1 and enhanced glycolysis in neutrophils promoted the production of S100A8/A9. Myeloid-restricted deletion of Slc2a1 (GLUT-1) or pharmacological inhibition of S100A8/A9 reduced TIH-induced myelopoiesis and atherosclerosis. Conclusions: Together, these data provide a mechanism as to how TIH, prevalent in people with impaired glucose metabolism, contributes to cardiovascular disease. These findings provide a rationale for continual glucose control in these patients and may also suggest that strategies aimed at targeting the S100A8/A9-RAGE (receptor for advanced glycation end products) axis could represent a viable approach to protect the vulnerable blood vessels in diabetes mellitus. Graphic Abstract: A graphic abstract is available for this article.

Use of Glycated Hemoglobin (A1C) in the Diagnosis of Type 2 Diabetes Mellitus in Adults

2011 ◽  
Vol 35 (3) ◽  
pp. 247-249 ◽  
Author(s):  
Ronald M. Goldenberg ◽  
Alice Y.Y. Cheng ◽  
Zubin Punthakee ◽  
Maureen Clement
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hemoglobin A1c ◽  
Glycated Hemoglobin ◽  
Glycated Hemoglobin A1c
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