scholarly journals Comparative studies on novel combinations of pregabalin plus venlafaxine with standard diazepam and marketed combination of alprazolam plus sertraline for anxiety disorders

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Rahul P. Pol ◽  
ATUL RAMCHANDRA CHOPADE1,2 ◽  
Nilofar S. Naikwade1 ◽  
R. J. Dias3
Keyword(s):  
Clinical Utility ◽  
Elevated Plus Maze ◽  
Fixed Dose ◽  
Test Apparatus ◽  
Minimum Effective Dose ◽  
Plus Maze ◽  
Norepinephrine Reuptake Inhibitor ◽  
Animal Models Of Anxiety ◽  
Serotonin Norepinephrine Reuptake Inhibitor ◽  
Norepinephrine Reuptake

Summary Objective- In present study, eleven novel dose combinations of Pregabalin & Venlafaxine from minimum effective dose to higher anxiolytic dose were taken for assessment of anxiolytic activity in Swiss mice.Method — Classical animal models of anxiety vise: Elevated plus-maze model and Light & Dark Exploration test Apparatus. Diazepam was used as a standard anxiolytic. In addition the combinations were also compared with a fixed dose marketed combination of Alprazolam & Sertraline (Anxit Plus).Result — The results of the study reveal that combinations of Pregabalin & Venlafaxine (serotonin norepinephrine reuptake inhibitor) have better anxiolytic efficacy, which is comparable to Diazepam and Alprazolam-Sertraline combination.Conclusion- Further clinical studies are required for getting better idea about efficacy and clinical utility of Pregabalin-Venlafaxine combination.

scholarly journals The Effect of Serotonin-Norepinephrine Reuptake Inhibitor Milnacipran on Anxiety-like Behaviors in Diabetic Mice

2021 ◽  
Vol 8 (3) ◽  
pp. 200
Author(s):  
Tuhfatul Ulya ◽  
Chrismawan Ardianto ◽  
Mahardian Rahmadi ◽  
Dewi Wara Shinta ◽  
Junaidi Khotib
Keyword(s):  
Diabetes Mellitus ◽  
Neuronal Plasticity ◽  
Elevated Plus Maze ◽  
Stress Disorders ◽  
Inadequate Response ◽  
Antidepressant Agents ◽  
Footshock Stress ◽  
Plus Maze ◽  
Norepinephrine Reuptake Inhibitor ◽  
Serotonin Norepinephrine Reuptake Inhibitor

Background: Diabetes mellitus is a chronic disease that causes neuronal plasticity and increased hypothalamic pituitary adrenal (HPA) axis of stress disorders. The change in metabolism is reportedly associated with inadequate response to antianxiety and antidepressant agents. Objective: This study aimed to determine the effect of milnacipran antidepressants on anxiety-like behavior in mice with diabetes mellitus. Methods: Male ICR mice were divided into naive, stress, diabetes mellitus (DM), DM + stress groups to measure anxiety-like behavior. Diabetes mellitus was induced using alloxan, and electric footshock stress was used as a stressor for 14 consecutive days. Anxiety-like behavior was measured using the light-dark box (LDB) and elevated plus maze (EPM) test at days 0, 7 and 14. The antidepressant milnacipran (MIL) was given for 7 days, on days 8 to 14. On day 14, evaluation of anxiety-like behavior after administration of MIL was carried out in all groups using LDB and EPM tests. Results: The results showed that administration of milnacipran effectively ameliorated anxiety-like behavior in the non-DM, but not in the DM group, using the LDB test. A similar result was demonstrated in the EPM test showing the non-DM group's attenuation after milnacipran administration. Conclusion: The present results indicate that there is an inadequate attenuation of the anxiety-like behavior after treatment with milnacipran in diabetes conditions.

scholarly journals The novel dipeptide ligand of TASP

2019 ◽  
Vol 484 (2) ◽  
pp. 228-232
Author(s):  
O. A. Deeva ◽  
A. S. Pantileev ◽  
I. V. Rybina ◽  
M. A. Yarkova ◽  
T. A. Gudasheva ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Open Field Test ◽  
Anxiolytic Activity ◽  
The Novel ◽  
Minimum Effective Dose ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Order Of Magnitude ◽  
Preliminary Administration

Using the previously obtained first dipeptide ligand TSPO the N‑carbobenzoxy-L‑tryptophanyl-L‑isoleucine amide (GD‑23) as a basis, the new dipeptide was synthesized — the N‑phenylpropionyl–L‑tryptophanyl-L‑leucine amide (GD‑102). GD‑102 expressed anxiolytic activity in the open field test in BALB/c mice and in the elevated plus maze test in ICR mice. The minimum effective dose of GD‑102 was an order of magnitude lower than that of GD‑23. Preliminary administration of the TSPO selective antagonist, compound PK11195, completely blocked the anxiolytic activity of GD‑102, that indicated the participation of TSPO in the realization of the anxiolytic action GD‑102. The results were confirmed by molecular docking data.

TAKO TSUBO CARDIOMYOPATHY ASSOCIATED WITH AN OVERDOSE OF THE SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR VENLAFAXINE

2011 ◽  
Vol 22 ◽  
pp. S103-S104
Author(s):  
Eduardo Oliveros Acebes ◽  
Salvador Gamez Casado ◽  
Maria Ferrer Civeira ◽  
Inma Muñoz Roldán ◽  
Marta Clavero Olmos ◽  
...  
Keyword(s):  
Reuptake Inhibitor ◽  
Norepinephrine Reuptake Inhibitor ◽  
Tako Tsubo Cardiomyopathy ◽  
Serotonin Norepinephrine Reuptake Inhibitor ◽  
Norepinephrine Reuptake

Everyday Problems in Treating Depression: Focus on SNRIs

CNS Spectrums ◽  
2008 ◽  
Vol 13 (S11) ◽  
pp. 4-4 ◽  
Author(s):  
Siegfried Kasper
Keyword(s):  
Selective Serotonin Reuptake Inhibitors ◽  
Antidepressant Activity ◽  
New Class ◽  
Treatment Of Depression ◽  
Norepinephrine Reuptake Inhibitor ◽  
Dual Action ◽  
Everyday Problems ◽  
Serotonin Norepinephrine Reuptake Inhibitor ◽  
Poor Tolerability ◽  
Norepinephrine Reuptake

Most effective antidepressants directly or indirectly increase the synaptic concentrations of serotonin (5-HT) and/or norepinephrine (NE) by blocking the reuptake of one or both of the neurotransmitters. This property was initially discovered with the tricyclic antidepressants (TCAs). Their various additional interactions at different receptors and ion channels are not required for antidepressant action, but are responsible for the poor tolerability and toxicity in overdose of the early antidepressants.The selective serotonin reuptake inhibitors are effective and well tolerated. Selective norepinephrine reuptake inhibitors, such as reboxetine, also have proven antidepressant activity. A selective action on one or the other of the principal monoamines thus appears to be sufficient for antidepressant activity. The idea that a dual action on both neurotransmitters might produce greater efficacy in certain patients led to the development of the serotonin norepinephrine reuptake inhibitor (SNRI) antidepressants, which block the reuptake of both 5-HT and NE without the nonspecific, side-effect–inducing interactions of the TCAs. The three SNRIs—venlafaxine, milnacipran, and duloxetine—constitute a new class of antidepressants.Antidepressant response rates rarely exceed 60% to 70% and remission rates are usually <50%. Although SNRIs clearly provide superior efficacy in certain populations, their use has not dramatically changed antidepressant therapy. The search for agents that are more effective, rapidly acting, and better tolerated continues. However, clinicians must find ways to better use the antidepressants that are available today. This supplement, based on a symposium held at the International Forum on Affective Disorders in Budapest in December 2007, discusses several everyday problems in the treatment of depression, with a focus on SNRIs.

scholarly journals Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats

2018 ◽  
Vol 68 (3) ◽  
pp. 381-388 ◽  
Author(s):  
Blandina Bernal-Morales ◽  
Gabriel Guillén-Ruiz ◽  
Jonathan Cueto-Escobedo ◽  
Juan Francisco Rodríguez-Landa ◽  
Carlos M. Contreras
Keyword(s):  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Clinical Applications ◽  
Minimum Effective Dose ◽  
Single Session ◽  
Adult Rats ◽  
Stressed Group ◽  
Plus Maze ◽  
Forced Swim Stress

Abstract The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited an increase in anxiety-like behavior in the elevated plus maze (EPM) and open field test (OFT) compared to the non-stressed group. Diazepam (1 h before the tests) reduced anxiety-like behavior in rats forced to swim compared to the vehicle stressed group. The dose-response curve for diazepam indicated that the 0.5 mg kg−1 dose (1 h before the EPM and OFT) was the minimum effective dose in reducing anxiety-like behavior without altering locomotor activity in weaning rats. These results indicate that weaning rats can develop anxiety-like behavior after a brief, single session of stress, and that rats at this age are seemingly more sensitive to diazepam than adult rats, which may be taken into account for clinical applications.

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