Comparative studies on novel combinations of pregabalin plus venlafaxine with standard diazepam and marketed combination of alprazolam plus sertraline for anxiety disorders

Summary Objective- In present study, eleven novel dose combinations of Pregabalin & Venlafaxine from minimum effective dose to higher anxiolytic dose were taken for assessment of anxiolytic activity in Swiss mice.Method — Classical animal models of anxiety vise: Elevated plus-maze model and Light & Dark Exploration test Apparatus. Diazepam was used as a standard anxiolytic. In addition the combinations were also compared with a fixed dose marketed combination of Alprazolam & Sertraline (Anxit Plus).Result — The results of the study reveal that combinations of Pregabalin & Venlafaxine (serotonin norepinephrine reuptake inhibitor) have better anxiolytic efficacy, which is comparable to Diazepam and Alprazolam-Sertraline combination.Conclusion- Further clinical studies are required for getting better idea about efficacy and clinical utility of Pregabalin-Venlafaxine combination.

Content-based medical image retrieval system based on gradient orientation and edge information

Retrieval of biomedical pictures is a significant side of computer based diagnosis. It helps the radiologist and restorative authority to spot and analyze the particular disease. This paper proposes a Content Based Medical Image Retrieval (CBMIR) approach for retrieving similar biomedical images. The extraction of retrieving features is based on histogram of oriented gradients (HOG) and canny edge detection. To reduce the dimensionality, principal component analysis(PCA) is employed over the feature vector. The experiments are conducted on high-resolution computed tomography medical images of lungs. With the average retrieval rate (ARR) and average retrieval precision (ARP), the performance of the proposed approach is analyzed and compared with other existing methods viz. Local Binary Pattern (LBP), LBP with uniform patterns (LBPu2), Local Mesh Pattern with uniform patterns (LMePu2) and LMeP with gabor transform (GLMeP).

CASE REPORT OF DIGITAL NECROSIS DUE TO RADIAL ARTERY INJURY AND AN ASSOCIATION WITH THE ARTERIAL ANATOMY OF THE HAND

Radial artery puncture, an invasive procedure, is frequently used in critically-ill patients. Although considered safe, severe and rare complications such as finger necrosis can occur. Here we report a case of finger necrosis and discuss its relationship with the anatomy of hand arteries

HOMEOSTASIS CHANGE IN THE SMALL INTESTINE WITH DISTURBED REGIONAL BLOOD FLOW IN EARLY POSTNATAL ONTOGENESIS

Objective: A study of the ischemic damage course and regeneration in the small intestine with disturbed regional blood flow in early postnatal ontogenesis.Materials and Methods: The experiments were carried out on 30 puppies at the age from 1 to 4 weeks. The state of regional blood flow in the ischemic area of the small intestine was investigated by blood filling of tissues, metabolism - by redox potential, oxygen pressure and diffusion oxygen coefficient, lipid peroxidation activity and catalase activity. Database formation and statistical calculations were performed using the applied programmes "Microsoft Excel", "ANOVA" for "Windows".Results: The performed research showed that in animals of early age pronounced microcirculatory disorders were observed. About this evidenced significant tissue bloodfilling in the ischemic region of the small intestine. Essential disorder of the blood supply in the organ naturally led to a pronounced fall in the redox potential, the oxygen pressure, and the diffusion oxygen coefficient in the tissues.On a level with the disturbances in the electrogenesis and tissue oxygenation, we found a significant diminution in their antioxidant capacity, as evidenced by a pronounced increase in lipid peroxidation and a decrease in catalytic activity. Insufficient oxygen supply of tissues caused the development of irreversible changes in the intestinal wall, the disorder of the organ motility with frequent appearance of small intestinal intussusception.Conclusions: A significant disturbance of the small intestine blood supply at the early age, caused by an operating trauma, leads to a pronounced decrease in electrical activity and oxygenation of the organ tissues, accompanied by marked metabolic disorders.Oxygen starvation of tissues in the ischemic region of the small intestine at the early age contributes to the development of irreversible changes in the intestinal wall, and frequent disruption of the regeneration process in this area. Keywords: small intestine; local ischemia; early age

Surgical Anatomy of the liver

The liver is the second largest human organ and has got a complex internal vascular and ductal anatomy. It is subdivided into lobes, sections and segments and receives dual blood supply from the hepatic artery and portal vein. The hepatic veins drain the liver directly into the inferior vena to which the liver is intimately related. Anatomical variations are common. A thorough knowledge of the liver anatomy and its variations is of critical importance for safe and successful procedures and surgeries involving the liver.

Chemical Induced Liver Injury: Types, Mechanisms and Biomarkers

Liver is a primary organ involved in biotransformation of foods and drugs. Liver diseases are a major worldwide problem; Hepatic disorders are mainly caused by toxic chemicals, e.g. - alcohol, carbon tetra chloride, anticancer agent, analgesic, anti-inflammatory drugs, anti-tuberculosis agent and heavy metals. Various risk factors for liver damage include age, gender, alcoholism, nutrition and genetic polymorphisms of cytochrome P450 have also been considered. The present review enumerate various hepatic diseases, risk factors and chemicals induced hepatic injury via different mechanical pathway as well as numerous biochemical changes viz. serum biomarkers, proteomics biomarkers, genomic biomarkers, metabolic biomarkers and micro RNA. This review could be immensely useful for researchers especially for pharmacologists, toxicologist working on hepatotoxicity and drug research organization.

Acellular dermal matrix and gingival connective in the treatment of periodontal recessions – comparative clinical evaluation in humans

ABSTRACTDifferent periodontal surgical techniques have been proposed for the treatment of periodontal recessions. Among these, the graft of gingival connective tissue stands out for the high predictability of success. This work compared the clinical outcomes of treatment of periodontal recessions, using the gingival connective tissue grafts and acellular dermal matrix. A total of 72 recessions constituted the sample, divided equally into 2 groups. Group 1: treated with acellular dermal matrix graft (MDA) associated with the displaced: Group 2: treated with gingival connective tissue graft, also associated with the flap offset coronally. We evaluated the clinical parameters of probing depth, insert, clinical periodontal recession towards coronal-apical diameter mesio-distal of recessions, keratinized and mucosa thickness flap and influence of grafts in relation to root coverage. The initial measures were compared to those obtained with 45, 90 and 120 days after surgery. No statistically significant differences were found between the groups in terms of reduction of periodontal recessions, keratinized and mucosa flap thickness and of grafts in relation to root coverage. The Group 2 (CG) showed statistically significant reduction in the depth of drilling and clinical level of insertion, compared to group 1 (MDA). However, these differences were not clinically relevant. It was concluded that both the gingival connective tissue graft as the acellular dermal matrix can be used in the treatment of periodontal recessions, with a high predictability of success.Keywords: Gingival recession, connective tissue graft, acellular dermal matrix, periodontal surgery, gum recession, root coverage.

Gross anatomy of the nose, nasal cavity and larynx in the pampas deer (Ozotoceros bezoarticus, Linnaeus 1758)

Available information on the anatomy of the respiratory system of the pampas deer (Ozotoceros bezoarticus, Linnaeus 1758) is scarce, so the aim of this work was to describe the upper respiratory tract anatomy of this species. The study was performed with 10 adult animals of both sexes and the study method was simple dissection. Pampas deer had a nasolabial plane different to the small domestic ruminants. The nasal cavity had the fundamental conformation of the ruminants with simple winding of the dorsal concha and double winding of the ventral one. The vomeronasal organ communicated directly with the oral cavity by the incisive duct. The larynx was located ventrally to the first two cervical vertebrae. The total length of the larynx was 52.76 ± 7.66 mm from the epiglottis to the cricoid cartilage. The dorsoventral length was 30.32 ± 3.71 mm. It is necessary to make detailed histological examinations of the distribution of the olfactory epithelium versus non-sensory epithelium within the nasal cavity. These data are essential to understand the function of the turbinates and the nasal cavity in general. In the same way, detailed studies of the physiology of the vomeronasal organ and larynx are necessary.

Radiographic position of the mental foramen

Background: The location of the mental foramen is important for dental surgeons. Variations in its locations can be a cause of complications during local anesthesia or surgical procedures which involving mandible. The usual location of the mental foramen in an Indian population has not been previously reported.Aim: The purpose of this study was to evaluate the most common location of the mental foramen in an Indian population.Materials and Methods: 260 panoramic radiographs were evaluated with regard to the location and symmetry of the mental foramina in male and female subjects.Results: We found that the mental foramen was located between the first and second premolars in 20% , in line with the second premolar in 61%, between the second premolar and mesial root of first molar 3.8%, In the line of mesial root of first molar 5.3% and distal to mesial root of first molar 0.3%. It was symmetrical in 59 %.Conclusions: This study emphasis that the most common location of mental foramen is in the line of second premolar followed by between the two premolars. The clinician should asses the location of mental foramen before any surgical intervention involving mandible.

“Langerhan Cell Histiocytosis –Review Of Literature”

Background: Langerhans cell histiocytosis is a relatively rare unique disease process characterized by an abnormal proliferation of immature dendritic cells usually affecting children and young adults.Discussion: Histiocytosis are rare diseases of great biological variability and a wide range of clinical manifestations. The first manifestations of LCH may occur in the oral cavity may vary from a continuous gingival infection or a dental abscess to necrotizing ulcerating defects or a painful jaw swelling.The criteria for diagnosis of LCH includes identification of the characteristic clinical features histopathological, Immunohistochemical findings. Various treatment modalities has been adopted including wide surgical excision along with radiotherapy,chemotherapy ,isolated radiotherapy and use of alkalizing agents.Keywords- Langerhans cell histiocytosis, Histiocytosis X , Osteolysis of skull