A Convenient Synthesis of new Phenanthrolinone and Naphthyridinone Derivatives: Evaluation of their Biological activity

2014 ◽  
Vol 9 (1) ◽  
pp. 1866-1872
Author(s):  
Mona A. Hosny ◽  
Wafaa A. Mokbel ◽  
Emtithal A. El-Sawi
Keyword(s):  
Staphylococcus Aureus ◽  
Biological Activity ◽  
Candida Albicans ◽  
Sodium Hydroxide ◽  
Good Activity ◽  
Substituted Phenols ◽  
Smiles Rearrangement ◽  
Convenient Synthesis ◽  
Effective Synthesis ◽  
And Staphylococcus Aureus

A novel and effective synthesis of substituted acetamide via smiles rearrangement is described. Treatment of phenols with 2-chloroacetamide in the presence of sodium hydroxide and DMA where substituted phenols, which contain electron withdrawing groups, are more reactive for smiles rearrangement. The reaction followed by cyclization of the product by E.A.A. afforded the corresponding substituted phenanthrolinone and naphthyridinone in good yields and showed higher activity against (G- and G+, Eschierchia coli and Staphylococcus aureus respectively) and good activity toward Aspergillius flavus and Candida albicans.

scholarly journals A Convenient Synthesis of new Phenanthrolinone and Naphthyridinone Derivatives: Evaluation of their Biological activity

2013 ◽  
Vol 9 (1) ◽  
pp. 1866-1872
Author(s):  
Mona A. Hosny ◽  
Wafaa A. Mokbel ◽  
Emtithal A. El-Sawi
Keyword(s):  
Staphylococcus Aureus ◽  
Biological Activity ◽  
Candida Albicans ◽  
Sodium Hydroxide ◽  
Good Activity ◽  
Substituted Phenols ◽  
Smiles Rearrangement ◽  
Convenient Synthesis ◽  
Effective Synthesis ◽  
And Staphylococcus Aureus

A novel and effective synthesis of substituted acetamide via smiles rearrangement is described. Treatment of phenols with 2-chloroacetamide in the presence of sodium hydroxide and DMA where substituted phenols, which contain electron withdrawing groups, are more reactive for smiles rearrangement. The reaction followed by cyclization of the product by E.A.A. afforded the corresponding substituted phenanthrolinone and naphthyridinone in good yields and showed higher activity against (G- and G+, Eschierchia coli and Staphylococcus aureus respectively) and good activity toward Aspergillius flavus and Candida albicans.

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

2019 ◽  
Vol 70 (10) ◽  
pp. 3603-3610
Author(s):  
Madalina Mihalache ◽  
Cornelia Guran ◽  
Aurelia Meghea ◽  
Vasile Bercu ◽  
Ludmila Motelica ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Copper Complexes ◽  
Substrate Adhesion ◽  
Inert Substrate

The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: [Cu(TB)(HA)]Cl (C1), [Cu(TB)(HA)CH3COO]�H2O (C2) and [Cu(TB)(HA)](NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications.

Candida albicans: Molecular interactions with Pseudomonas aeruginosa and Staphylococcus aureus

2014 ◽  
Vol 28 (4) ◽  
pp. 85-96 ◽  
Author(s):  
Allia K. Lindsay ◽  
Deborah A. Hogan
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Candida Albicans ◽  
Molecular Interactions ◽  
And Staphylococcus Aureus

scholarly journals Effect of plants extracts on the growth of Candida albicans and Staphylococcus aureus

2016 ◽  
Vol 10 (16) ◽  
pp. 337-345
Author(s):  
Hassan Abdullah Al Abdalall Amira
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
And Staphylococcus Aureus

scholarly journals In vitro interactions between fluconazole and minocycline against mixed cultures of Candida albicans and Staphylococcus aureus

2015 ◽  
Vol 48 (6) ◽  
pp. 655-661 ◽  
Author(s):  
Hui Li ◽  
Caiqing Zhang ◽  
Ping Liu ◽  
Weiguo Liu ◽  
Yuan Gao ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Mixed Cultures ◽  
And Staphylococcus Aureus ◽  
In Vitro Interactions

scholarly journals Antibacterial and Antifungal Activity of Zinc(II) Carboxylates With/Without N-Donor Organic Ligands

2002 ◽  
Vol 8 (5) ◽  
pp. 269-274 ◽  
Author(s):  
V. Zelenák ◽  
K. Györyová ◽  
D. Mlynarcík
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Organic Ligands ◽  
Antibacterial And Antifungal Activity ◽  
Bacterial Strains ◽  
Structural Types ◽  
Antibacterial And Antifungal

The antibacterial and antifungal activity of zinc(II) carboxylates with composition Zn(RCOO)2•nH2O(R =H-, CH3− , CH3CH2CH2- , (CH3)2CH- , XCH2- , X=Cl, Br, I, n=0 or 2), [ZnX2(Nia+CH2COO-)2] (Nia=nicotinamide, X=Cl, Br, I) and [Zn(XCH2COO)2(Caf)2]•2H2O (Car=caffeine, X=Cl, Br) is studied against bacterial strains Staphylococcus aureus, Escherichia coli and yeast Candida albicans. The structural types are assigned to the prepared compounds and the influence of (i) carboxylate chain length, (ii) substitution of hydrogen atom of carboxylate by halogen and (iii) presence of N-donor organic ligands on the biological activity is discussed.

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