Faculty Opinions recommendation of Efficacy of ethanol against Candida albicans and Staphylococcus aureus polymicrobial biofilms.

Author(s):  
Mahmoud Ghannoum ◽  
Pranab Mukherjee
2014 ◽  
Vol 58 (12) ◽  
pp. 7606-7610 ◽  
Author(s):  
Kaat De Cremer ◽  
Nicolas Delattin ◽  
Katrijn De Brucker ◽  
Annelies Peeters ◽  
Soña Kucharíková ◽  
...  

ABSTRACTWe here report on thein vitroactivity of toremifene to inhibit biofilm formation of different fungal and bacterial pathogens, includingCandida albicans,Candida glabrata,Candida dubliniensis,Candida krusei,Pseudomonas aeruginosa,Staphylococcus aureus, andStaphylococcus epidermidis. We validated thein vivoefficacy of orally administered toremifene againstC. albicans and S. aureusbiofilm formation in a rat subcutaneous catheter model. Combined, our results demonstrate the potential of toremifene as a broad-spectrum oral antibiofilm compound.


Author(s):  
Minasari Minasari ◽  
Dennis Dominika

Cinnamon is one of the spices that has been used for a long time, even before 2100 BC as an essential material to mummify a king's body and also as addition for foods and drinks to increase the flavours. Cinnamon has three active components such as cinnamaldehyd, eugenol and linalool. Cinnamon has good fungicidal and fungistatic effect against Candida albicans and bacteristatic, bactericidal effect against Staphylococcus aureus. Cinnamon can be used to decrease the amount of Candida albicans and Staphylococcus aureus colonies, so the researcher is interested to examine the fungistatic, fungicidal, bacteristatic dan bactericidal effect against Candida albicans and Staphylococcus aureus. The goal of this research is to determine the effect of different concentrations of cinnamon extract against Candida albicans and Staphylococcus aureus.In this research, the extract's concentrations that are used are 100%, 50%, 25%, 12,5%, 6,25%, 3,125%, 1,56%, 0,78%, 0,39%, 0,195% and also two controls which are formaldehyd and aquadest. The extract used in this research is obtained by extraction method. Dilution technique is used in the test with three times replication. This research is experimental laboratorium type with pretest-postest design. Kruskal-Wallis and Mann-Whitney test is used to analyze the data.The result show that concentration 0,78 % extract has shown fungistatic effect and concentration 25% has shown fungicidal effect against Candida albicans, and concentration 1,562% bacteristatic, concentration 50% bactericidal Staphylococcus aureus. From double comparison table, we can conclude that there are significant difference between each concentration's effect against Candida albicans and Staphylococcus aureus.The result shows that the increase of cinnamon extract's concentration will lessen the remaining colonies of Candida albicans.


2017 ◽  
Vol 7 (4) ◽  
pp. 424-431 ◽  
Author(s):  
N. A. Ushakova ◽  
A. E. Dontsov ◽  
N. L. Sakina ◽  
E. S. Brodsky ◽  
I. A. Ratnikova ◽  
...  

<p>Eumelanin type pigments are synthesized at all the stages of the life cycle of the fly Hermetia illucens: in the larvae, pre-pupae,<br />pupae and adult flies (dead flies). The greatest content of melanin was recorded in the cuticles. Melanin was present not only<br />in the cuticle, hence it remained in the cuticle after the emergence of the adult fly. It was also found in the insect body in a<br />complex with lipids. In pupae, it is mostly lauric acid that was associated with melanin. Its proportion in the melanin-chitosan<br />complex was 80%. The isolated melanin-chitosan complex of adult flies showed a wide range of antibacterial activity, inhibiting<br />the growth of 21 out of the 25 of the test cultures. The melanin-chitosan complex of empty pupal membranes and alcohol<br />suspension of pupal melanin inhibited twice as smaller number of test cultures and the above activity was absolutely in the<br />pupal chitosan. The largest zone of growth inhibition was recorded with respect to Aspergillus niger, Candida albicans,<br />salmonella, and Staphylococcus aureus. An alcohol suspension of pupal melanin inhibited the growth of 10 test cultures. In this<br />case the greatest activity was shown in relation to Mycobacterium B5 and Acinetobacter sp. 1182.</p>


Sign in / Sign up

Export Citation Format

Share Document