Histologic and micro–computed tomographic evaluation of the osseointegration of a nonresorbable bone substitute in alveoli of ponies after tooth extraction

The objective of this study was to evaluate the biological responses of three different mixtures of a bone substitute material placed in tooth extraction sites to determine which mixture best enhances bone formation. Under general anesthesia three adult mongrel canine had bilateral extractions of the second and fourth premolar bicuspids. Each site was modeled into 3-wall defect with box-like dimensions and having the window on the buccal (outer) side of the mandible. A synthetic hydroxyapatite bone cement (HAC) was prepared three different ways: 1) 2.5 gms HAC + 0.75 cc sterile water (W); 2) 2.5 gms HAC + 0.75 cc 2% Hydroxypropylmethylcellulose in sterile water (HPMC); 3) 2.5 gms HAC + 0.75 cc Sodium Phosphate [45mM/15mL Phosphate + 60 MEq/15mL Sodium] (SP). Each mixture was syringe injected into a different extraction site and the fourth site received no cement to serve as a control site, and after sites were filled, a periodontal flap closure was accomplished with a 4-0 VICRYL suture.

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Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing

Journal of Dental Research ◽

10.1177/0022034518818456 ◽

2019 ◽

Vol 98 (4) ◽

pp. 450-458 ◽

Cited By ~ 11

Author(s):

M. Arioka ◽

X. Zhang ◽

Z. Li ◽

U.S. Tulu ◽

Y. Liu ◽

...

Keyword(s):

Bone Healing ◽

Tooth Extraction ◽

Bone Repair ◽

Alveolar Bone ◽

Bone Fragility ◽

Reconstructive Procedures ◽

Osteoprogenitor Cells ◽

Computed Tomographic ◽

Cellular Assays ◽

Socket Healing

Osteoporosis is associated with decreased bone density and increased bone fragility, but how this disease affects alveolar bone healing is not clear. The objective of this study was to determine the extent to which osteoporosis affects the jaw skeleton and then to evaluate possible mechanisms whereby an osteoporotic phenotype might affect the rate of alveolar bone healing following tooth extraction. Using an ovariectomized mouse model coupled with micro–computed tomographic imaging, histologic, molecular, and cellular assays, we first demonstrated that the appendicular and jaw skeletons both develop osteoporotic phenotypes. Next, we demonstrated that osteoporotic mice exhibit atrophy of the periodontal ligament (PDL) and that this atrophy was accompanied by a reduction in the pool of osteoprogenitor cells in the PDL. The paucity of PDL-derived osteoprogenitor cells in osteoporotic mice was associated with significantly slower extraction socket healing. Collectively, these analyses demonstrate that the jaw skeleton is susceptible to the untoward effects of osteoporosis that manifest as thinner, more porous alveolar bone, PDL thinning, and slower bone repair. These findings have potential clinical significance for older osteopenic patients undergoing reconstructive procedures.

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Evaluation of a bone substitute covered with a collagen membrane for ridge preservation after tooth extraction. Clinical and tomographic randomized controlled study in humans

Clinical Oral Implants Research ◽

10.1111/clr.13140 ◽

2018 ◽

Vol 29 (4) ◽

pp. 424-433 ◽

Cited By ~ 2

Author(s):

Felipe Anderson Sousa Nunes ◽

Túlio B. Pignaton ◽

Arthur B. Novaes ◽

Mário Taba ◽

Michel R. Messora ◽

...

Keyword(s):

Bone Substitute ◽

Tooth Extraction ◽

Randomized Controlled Study ◽

Controlled Study ◽

Collagen Membrane ◽

Ridge Preservation ◽

Randomized Controlled

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A Novel Procedure for the Immediate Reconstruction of Severely Resorbed Alveolar Sockets for Advanced Periodontal Disease

Case Reports in Dentistry ◽

10.1155/2017/9370693 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5

Author(s):

Mario Aimetti ◽

Valeria Manavella ◽

Luca Cricenti ◽

Federica Romano

Keyword(s):

Periodontal Disease ◽

Tooth Extraction ◽

Cone Beam ◽

Scaffold Material ◽

New Bone Formation ◽

Immediate Reconstruction ◽

Computed Tomographic ◽

Implant Placement ◽

Bone Deficiency ◽

Computed Tomographic Scan

Background. Several clinical techniques and a variety of biomaterials have been introduced over the years in an effort to overcome bone remodeling and resorption after tooth extraction. However, the predictability of these procedures in sockets with severely resorbed buccal/lingual plate due to periodontal disease is still unknown. Case Description. A patient with advanced periodontitis underwent extraction of upper right lateral and central incisors. The central incisor exhibited complete buccal bone plate loss and a 9 mm vertical bone deficiency on its palatal side. The alveolar sockets were filled with collagen sponge and covered with a nonresorbable high-density PTFE membrane. Primary closure was not attained and any rigid scaffold material was not used. Histologic analysis provided evidence of new bone formation. At 12 months a cone-beam computed tomographic scan revealed enough bone volume to insert two conventional dental implants in conjunction with minor horizontal bone augmentation procedures. Clinical Implications. This case report would seem to support the potential of the proposed reconstructive approach in changing the morphology of severely resorbed alveolar sockets, minimizing the need for advanced bone regeneration procedures during implant placement.

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