Effects of intravenous administration of lipopolysaccharide on cytochrome P450 isoforms and hepatic drug metabolizing enzymes in swine

2010 ◽  
Vol 71 (3) ◽  
pp. 342-348 ◽  
Author(s):  
Michael J. Myers ◽  
Dorothy E. Farrell ◽  
Karyn D. Howard ◽  
Joseph C. Kawalek
Keyword(s):  
Cytochrome P450 ◽  
Intravenous Administration ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug ◽  
Cytochrome P450 Isoforms

scholarly journals Effects of Cyclamen trochopteranthum on hepatic drug-metabolizing enzymes

2011 ◽  
Vol 63 (3) ◽  
pp. 545-555 ◽  
Author(s):  
Sevki Arslan ◽  
Ozden Ozgun ◽  
Gurbet Celik ◽  
Asli Semiz ◽  
Olcay Dusen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Mrna Level ◽  
Drug Metabolizing Enzymes ◽  
Mrna Levels ◽  
Rt Pcr ◽  
Metabolizing Enzymes ◽  
Hepatic Drug ◽  
Tuber Extract ◽  
Different Doses

The modulatory effects of the Cyclamen trochopterantum tuber extract on hepatic drug-metabolizing enzymes, including aniline 4-hydroxylase (A4H; CYP2E1), ethoxyresorufin O-deethylase (EROD; CYP1A), methoxyresorufin O-demethylase (MROD; CYP1A), caffeine N-demethylase (C3ND; CYP1A2) aminopyrene N-demethylase (APND; CYP2C6), and erythromycin N-demethylase (ERND; CYP3A1), were examined in vivo in rats. The activities of all of these enzymes were induced by the cyclamen extract. In addition, Western-blot and RT-PCR results clearly showed that CYP2E1, CYP1A1/CYP1A2 and CYP2C6 protein and mRNA levels were substantially increased by four different doses of cyclamen. Although, the CYP3A1 protein level was increased significantly, the mRNA level was not changed. These results indicate that cyclamen tuber extract might have a potential not only to inhibit and/or induce the metabolism of certain co-administered drugs but also influence the development of toxicity and carcinogenesis due to the induction of the cytochrome P450-dependent drug-metabolizing enzymes.

Comparative inhibitory effects of mefloquine and primaquine on hepatic drug-metabolizing enzymes

1990 ◽  
Vol 39 (1) ◽  
pp. 212-216 ◽  
Author(s):  
Thananda Sukhumanan ◽  
Wichitra Suphakawanich ◽  
Amnuay Thithapandha
Keyword(s):  
Drug Metabolizing Enzymes ◽  
Inhibitory Effects ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

Induction of hepatic drug metabolizing enzymes in mammals by pesticides: A review

1980 ◽  
Vol 15 (6) ◽  
pp. 723-754 ◽  
Author(s):  
Ernest Hodgson ◽  
Arun P. Kulkarni ◽  
David L. Fabacher ◽  
Karen M. Robacker
Keyword(s):  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

Microscope immersion oils: effects of skin application on cutaneous and hepatic drug-metabolizing enzymes

1975 ◽  
Vol 24 (7) ◽  
pp. 779-783 ◽  
Author(s):  
David R. Bickers ◽  
Julie Eiseman ◽  
Attallah Kappas ◽  
Alvito P. Alvares
Keyword(s):  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

Effects of Garlic Powders with Varying Alliin Contents on Hepatic Drug Metabolizing Enzymes in Rats

2003 ◽  
Vol 51 (26) ◽  
pp. 7617-7623 ◽  
Author(s):  
Anne-Marie Le Bon ◽  
Marie-France Vernevaut ◽  
Lucien Guenot ◽  
Remi Kahane ◽  
Jacques Auger ◽  
...  
Keyword(s):  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hepatic Drug
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