A Species Difference in Conditioned Emotional Response

1964 ◽  
Vol 15 (2) ◽  
pp. 579-585 ◽  
Author(s):  
Norman D. Henderson
Keyword(s):  
Emotional Response ◽  
Species Differences ◽  
Conditioned Emotional Response ◽  
Species Difference ◽  
Quantitative Measure ◽  
Exploratory Activity ◽  
Activity Level ◽  
Old Rats ◽  
Rats And Mice

A technique to produce a quantitative measure of CER without pretraining is presented. The response, a change in S's exploratory activity during the CS, occurs rapidly in even 3-wk. old rats and mice. Species differences occur in the reaction to CS, US, and CS-US pairings. Although rats tend to suppress activity during CS as a result of CS-US pairings, the shock or buzzer alone increases activity level; while the opposite is true of mice.

Effects of Amobarbital on the Conditioned Emotional Response and Conditioned Avoidance Response

1966 ◽  
Vol 16 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Dennis K. Kamano ◽  
Louis K. Martin ◽  
Michael E. Ogle ◽  
Barbara J. Powell
Keyword(s):  
Avoidance Response ◽  
Emotional Response ◽  
Conditioned Emotional Response ◽  
Conditioned Avoidance ◽  
Conditioned Avoidance Response

Developmental Changes in Retrograde Messengers Involved in Depolarization-Induced Suppression of Excitation at Parallel Fiber-Purkinje Cell Synapses in Rodents

2007 ◽  
Vol 97 (1) ◽  
pp. 824-836 ◽  
Author(s):  
Francis Crepel
Keyword(s):  
Purkinje Cell ◽  
Indirect Effects ◽  
Cannabinoid Receptor ◽  
Parallel Fiber ◽  
Developmental Changes ◽  
Wild Type ◽  
Cb1 Cannabinoid Receptor ◽  
Old Rats ◽  
Rats And Mice ◽  
Retrograde Messenger

At parallel fiber (PF) to Purkinje cell (PC) synapses, depolarization-induced suppression of excitation (DSE) and suppression of PF-excitatory postsynaptic currents (EPSCs) by activation of postsynaptic mGluR1 glutamate (Glu) receptors involve retrograde release of endocannabinoids. However, Levenes et al. suggested instead that Glu was the retrograde messenger in this latter case. Because the study by Levenes et al. was performed in nearly mature rats, whereas most others were performed in juvenile animals, DSE was re-investigated in juvenile versus nearly mature rats and mice. Indeed, DSE was preferred here to agonist-induced suppression of PF-EPSCs, to avoid possible indirect effects in this latter case. In 10- to 12-day-old rats, DSE of PF-EPSCs was entirely mediated through retrograde release of endocannabinoids. In 18- to 22-day-old-rats, DSE was partly resistant to CB1 cannabinoid receptor antagonists. The remaining component was potentiated by the Glu uptake inhibitor d-threo-beta-benzyloxyaspartate (d-TBOA) and blocked by the desensitizing kainate (KA) receptor agonist (2S,4R)-4-methylglutamic acid (SYM 2081). This SYM-2081-sensitive component of DSE was accompanied by a paired-pulse facilitation increase that was also potentiated by d-TBOA and blocked by SYM 2081. In nearly mature wild-type and GluR6 −/− mice, results fully confirmed the presence of an endocannabinoid-independent component of DSE that involves retrograde release of Glu and activation of presynaptic KA receptors including GluR6 receptor subunits. Therefore retrograde release of Glu by PCs participates to DSE at PF-PC synapses in nearly mature rodents but not in juvenile ones, and Glu probably operates through activation of presynaptic KA receptors that include GluR6 receptor subunits.

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