scholarly journals Erratum to : Optimal Combination of Exploration Techniques Based on the Information-cost Function

1995 ◽  
Vol 111 (4) ◽  
pp. e1-e1
1995 ◽  
Vol 111 (3) ◽  
pp. 145-147 ◽  
Author(s):  
Tetsuya SHOJI ◽  
Ryoichi KOUDA ◽  
Hiroaki KANEDA

1998 ◽  
Vol 57 (1) ◽  
pp. 932-940 ◽  
Author(s):  
S. Blanco ◽  
A. Figliola ◽  
R. Quian Quiroga ◽  
O. A. Rosso ◽  
E. Serrano

Liquidity ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Yanti Budiasih

The purpose of this study are to (1) determine the combination of inputs used in producing products such as beef sausages and veal sausage meatball; and (2) determine the optimal combination whether the product can provide the maximum profit. In order to determine the combination of inputs and maximum benefits can be used linear programming with graphical and simplex method. The valuation result shows that the optimal input combination would give a profit of Rp. 1.115 million per day.


2019 ◽  
Author(s):  
Jacob Porter ◽  
Oscar Vivas-Rodriguez ◽  
C. David Weaver ◽  
Eamonn Dickson ◽  
Abdulmohsen Alsafran ◽  
...  

A set of novel Kv7.2/7.3 (KCNQ2/3) channel blockers was synthesized to address several liabilities of the known compounds XE991 (metabolic instability and CYP inhibition) and the clinical compound DMP 543 (acid instability, insolubility, and lipophilicity). Using the anthrone scaffold of the prior channel blockers, alternative heteroarylmethyl substituents were installed via enolate alkylation reactions. Incorporation of a pyridazine and a fluorinated pyridine gave an analog (JDP-107) with an optimal combination of potency (IC<sub>50</sub>= 0.16 𝜇M in a Kv7.2 thallium flux assay), efficacy in a Kv7.2/7.3 patch clamp assay, and drug-like properties.


2017 ◽  
Author(s):  
James Gibson

Despite what we learn in law school about the “meeting of the minds,” most contracts are merely boilerplate—take-it-or-leave-it propositions. Negotiation is nonexistent; we rely on our collective market power as consumers to regulate contracts’ content. But boilerplate imposes certain information costs because it often arrives late in the transaction and is hard to understand. If those costs get too high, then the market mechanism fails. So how high are boilerplate’s information costs? A few studies have attempted to measure them, but they all use a “horizontal” approach—i.e., they sample a single stratum of boilerplate and assume that it represents the whole transaction. Yet real-world transactions often involve multiple layers of contracts, each with its own information costs. What is needed, then, is a “vertical” analysis, a study that examines fewer contracts of any one kind but tracks all the contracts the consumer encounters, soup to nuts. This Article presents the first vertical study of boilerplate. It casts serious doubt on the market mechanism and shows that existing scholarship fails to appreciate the full scale of the information cost problem. It then offers two regulatory solutions. The first works within contract law’s unconscionability doctrine, tweaking what the parties need to prove and who bears the burden of proving it. The second, more radical solution involves forcing both sellers and consumers to confront and minimize boilerplate’s information costs—an approach I call “forced salience.” In the end, the boilerplate experience is as deep as it is wide. Our empirical work should reflect that fact, and our policy proposals should too.


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