scholarly journals Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin

2020 ◽  
Vol 70 (1) ◽  
pp. 77-88 ◽  
Author(s):  
Namfa Sermkaew ◽  
Thipapun Plyduang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Moringa Oleifera ◽  
Delivery Systems ◽  
Polyethylene Glycol 400 ◽  
Peg 400 ◽  
Enhanced Dissolution ◽  
Promising Strategy ◽  
Herbal Medicinal ◽  
Percentage Ratio

AbstractThe aim of the present study was to develop self-microemulsifying drug delivery systems (SMEDDS) of the extract of Moringa oleifera, a herbal medicinal plant. Kaempferol and quercetin, the flavonoids present in the leaf extract of M. oleifera, were chosen as markers for quantification. The optimized formulation of SMEDDS consisted of propylene glycol dicaprylocaprate, polysorbate 80, and polyethylene glycol 400 (PEG 400) in a percentage ratio of 20:60:20 (m/m). SMEDDS emulsified immediately (within 20 s) after dilution in water, resulting in transparent microemulsions with a droplet size of 49 nm. SMEDDS could increase the solubility of kaempferol and quercetin to nearly 100 % within 15 min, whereas only a 30 % improvement in solubility was achieved in the case of crude extract. These results demonstrated SMEDDS to be a promising strategy to improve the solubility of M. oleifera extract-derived drugs, which, in turn, could prove beneficial to the herbal medicine field.

A Triple-responsive Targeted Hybrid Liposomes with High MRI Performance for Tumor Diagnosis and Therapy

2021 ◽  
Author(s):  
Weihe Yao ◽  
Chenyu Liu ◽  
Ning Wang ◽  
Hengjun Zhou ◽  
Hailiang Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Tumor Diagnosis ◽  
Diagnosis And Therapy ◽  
Promising Strategy ◽  
Therapy And Diagnosis

The targeted multi-responsive drug delivery systems with MRI capacity were anticipated as a promising strategy for tumor therapy and diagnosis. Herein, we successfully synthesized anisamide-modified and non-modified UV/GSH-responsive molecules (10,10-NB-S-S-P-AA...

Zeta potential changing self-emulsifying drug delivery systems utilizing a novel Janus-headed surfactant: A promising strategy for enhanced mucus permeation

2019 ◽  
Vol 291 ◽  
pp. 111285 ◽  
Author(s):  
Faezeh Sharifi ◽  
Imran Nazir ◽  
Mulazim Hussain Asim ◽  
Mansour Jahangiri ◽  
Pedram Ebrahimnejad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Promising Strategy

scholarly journals Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

2012 ◽  
Vol 431 (1-2) ◽  
pp. 161-175 ◽  
Author(s):  
Ana Maria Sierra Villar ◽  
Beatriz Clares Naveros ◽  
Ana Cristina Calpena Campmany ◽  
Monserrat Aróztegui Trenchs ◽  
Coloma Barbé Rocabert ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Design And Optimization ◽  
Enhanced Dissolution

Olmesartan Medoxomil-Loaded Self-Nanoemulsifying Drug Delivery Systems: Design, In-Vitro Characterization, and Pharmacokinetic Assessments in Rabbits Via LC-MS/MS

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
El-Assal M. I. A. ◽  
El-Gendy M. A. ◽  
Tadros M. I. ◽  
El-Gazayerly O. N.
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Drug Delivery Systems ◽  
Oral Absorption ◽  
Systems Design ◽  
Olmesartan Medoxomil ◽  
Delivery Systems ◽  
Log P ◽  
Polyethylene Glycol 400

Olmesartan medoxomil (OLM) is a lipophilic (log P = 4.31) antihypertensive drug suffering from limited oral bioavailability in humans (26%) due to its low aqueous solubility, uncontrolled enzymatic conversion to the active metabolite (olmesartan; OL) and efflux by drug resistance pumps. Surmounting such limitations via incorporation of OLM into self-nanoemulsifying drug delivery systems (SNEDDS). Based on OLM-equilibrium solubility studies in various oils, surfactants and co-surfactants, Capmul® MCM, Tween® 20, Cremophor® EL and polyethylene glycol-400 (PEG) were combined in different ratios to plot ternary phase diagrams. OLM-loaded SENDDS were developed and evaluated for particle size, polydispersity index (PDI), zeta potential, self-emulsification time, morphology, drug released percentages after 5-min (Q5min%), 1-hour (Q1h%) and dissolution efficiency percentages (DE1h%). The OL pharmacokinetics from SNEDDS (F6) and Benicar® tablets were evaluated (LC-MS/MS) in rabbits. Spherical OLM-loaded SNEDDS were developed. The best-achieved SNEDDS (F6) showed short emulsification time (13 s), fine droplet size (60.00 nm), low PDI (0.25), negative zeta potential (-14.4 mV), promising dissolution parameters; Q5min% (29.78%), Q1h% (66.69%) and DE1h%(47.96%) and enhanced in vivo absorption characteristics; shorter Tmax, higher Cmax and larger AUC(0−48h; suggesting its potential for the enhancement of the oral absorption of practically insoluble drugs; like OLM.

Development and Optimization of Self-emulsifying Drug Delivery Systems (SEDDS) for Enhanced Dissolution and Permeability of Rosuvastatin

2016 ◽  
Vol 13 (3) ◽  
pp. 362-370 ◽  
Author(s):  
H. Y. Karasulu ◽  
E. Gündoğdu ◽  
T. Turgay ◽  
U. Ö. Türk ◽  
S. Apaydın ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Enhanced Dissolution

Co-delivery of doxorubicin and methotrexate by dendritic chitosan-g-mPEG as a magnetic nanocarrier for multi-drug delivery in combination chemotherapy

2017 ◽  
Vol 8 (47) ◽  
pp. 7333-7350 ◽  
Author(s):  
Mahdi Rahimi ◽  
Kazem D. Safa ◽  
Roya Salehi
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Combination Chemotherapy ◽  
Anticancer Agents ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Synergistic Effects ◽  
Delivery Systems ◽  
Promising Strategy

Nanoparticulate drug delivery systems have the potential to improve the therapeutic efficacy of anticancer agents, and combination therapy is a promising strategy for clinical cancer treatment with synergistic effects.

scholarly journals INTERAÇÃO DO LAPACHOL COM NANOPLATAFORMAS MICELARES DRUG DELIVERY

2021 ◽  
Vol 13 (1) ◽  
pp. 09-18
Author(s):  
Katieli da Silva Souza Campanholi ◽  
Flávia Amanda Pedroso de Morais ◽  
Évelin Lemos de Oliveira ◽  
Maycon Renan Santos Lima ◽  
Elza Aparecida da Silva ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Delivery Systems ◽  
Clinical Use ◽  
High Toxicity ◽  
Fluorescence Emission Spectra ◽  
Micellar Systems ◽  
Promising Strategy

The high toxicity of several systemically administered drugs is due to low specificity to diseased cells. This results in adverse effects and discomfort to patients. A promising strategy to enhance the therapeutic efficacy and clinical use of activeingredients is their incorporation into nanostructured micellar systems. These nanocarriers are widely addressed in the literature as drug delivery systems. Thus, this paper discusses aspects related to the interaction capacity of the natural drug lapachol with two micellar systems (F127 and P123), aiming to obtain a new drug for systemic administration. For this, previous studies were conducted to evaluate the variations that the aggregation of lapachol results in its spectral behavior. Subsequently, the interaction of lapachol with drug delivery systems was investigated by monitoring the fluorescence emission spectra of the drug. In general, the results obtained were promising and enrich the current therapeutic arsenal with a new medicine proposal, whose drug has established ethnopharmacological and scientific recognition.

scholarly journals Phytosomes: A Promising Strategy for Enhanced Therapeutic Beneϐits of Phytochemicals

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3157-3163
Author(s):  
Kamal Saroha ◽  
Parul Waliyan ◽  
Rakesh Pahwa ◽  
Shweta Pal ◽  
Inderbir Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Herbal Extract ◽  
Herbal Extracts ◽  
Promising Strategy ◽  
Pharmacodynamic Profile ◽  
Novel Drug ◽  
Herbal Formulations ◽  
Phytochemical Constituent

Phytosomes are phytochemical based novel drug delivery systems that lead to better absorption, greater bioavailability in addition to improved therapeutic efficacy of numerous phytoconstituents. It is a supremely advanced form of herbal formulations which contains the active phytoconstituent of herbal extract bound by phospholipid molecule. Additionally, these also act as vesicular systems for various fascinating and significant phytoactive. The phytosomes technique produces remarkable minute spheres or tiny cells, which is helpful in the protection of active phytochemical constituent from destruction by the gastric environment. Furthermore, phytosomes also reveal efficient pharmacokinetic as well as pharmacodynamic profile compared to conventional herbal extracts. The current manuscript is a cogent attempt to review the potential pharmacological benefits of herbal extracts by forming an impressive and successful phytophospholipid complex.  Salient attributes, as well as promising and imperative applications of phytosomes, are illustrated in the manuscript. Recent advances in research endeavours, along with major inferences on effective phytosomal drug delivery systems, have also been highlighted.

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