A Triple-responsive Targeted Hybrid Liposomes with High MRI Performance for Tumor Diagnosis and Therapy

The targeted multi-responsive drug delivery systems with MRI capacity were anticipated as a promising strategy for tumor therapy and diagnosis. Herein, we successfully synthesized anisamide-modified and non-modified UV/GSH-responsive molecules (10,10-NB-S-S-P-AA...

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Hypoxia Responsive Drug Delivery Systems in Tumor Therapy

Current Pharmaceutical Design ◽

10.2174/1381612822666160217130049 ◽

2016 ◽

Vol 22 (19) ◽

pp. 2808-2820 ◽

Cited By ~ 13

Author(s):

Houman Alimoradi ◽

Siddharth S. Matikonda ◽

Allan B. Gamble ◽

Gregory I. Giles ◽

Khaled Greish

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Tumor Therapy ◽

Delivery Systems

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Polymeric Drug Delivery System Based on Pluronics for Cancer Treatment

Molecules ◽

10.3390/molecules26123610 ◽

2021 ◽

Vol 26 (12) ◽

pp. 3610

Author(s):

Jialin Yu ◽

Huayu Qiu ◽

Shouchun Yin ◽

Hebin Wang ◽

Yang Li

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Drug Delivery Systems ◽

Tumor Therapy ◽

Chemical Properties ◽

Drug Carriers ◽

Disease Diagnosis ◽

Delivery Systems ◽

Polymeric Drug Delivery ◽

Physical And Chemical

Pluronic polymers (pluronics) are a unique class of synthetic triblock copolymers containing hydrophobic polypropylene oxide (PPO) and hydrophilic polyethylene oxide (PEO) arranged in the PEO-PPO-PEO manner. Due to their excellent biocompatibility and amphiphilic properties, pluronics are an ideal and promising biological material, which is widely used in drug delivery, disease diagnosis, and treatment, among other applications. Through self-assembly or in combination with other materials, pluronics can form nano carriers with different morphologies, representing a kind of multifunctional pharmaceutical excipients. In recent years, the utilization of pluronic-based multi-functional drug carriers in tumor treatment has become widespread, and various responsive drug carriers are designed according to the characteristics of the tumor microenvironment, resulting in major progress in tumor therapy. This review introduces the specific role of pluronic-based polymer drug delivery systems in tumor therapy, focusing on their physical and chemical properties as well as the design aspects of pluronic polymers. Finally, using newer literature reports, this review provides insights into the future potential and challenges posed by different pluronic-based polymer drug delivery systems in tumor therapy.

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Environment Responsive Metal–Organic Frameworks as Drug Delivery System for Tumor Therapy

Nanoscale Research Letters ◽

10.1186/s11671-021-03597-w ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Chao Yan ◽

Yue Jin ◽

Chuanxiang Zhao

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Tumor Therapy ◽

Metal Organic Frameworks ◽

Delivery Systems ◽

Drug Uptake ◽

High Concentration ◽

Metal Organic

AbstractNanoparticles as drug delivery systems can alter the drugs' hydrophilicity to affect drug uptake and efflux in tissues. They prevent drugs from non-specifically binding with bio-macromolecules and enhance drug accumulation at the lesion sites, improving therapy effects and reducing unnecessary side effects. Metal–organic frameworks (MOFs), the typical nanoparticles, a class of crystalline porous materials via self-assembled organic linkers and metal ions, exhibit excellent biodegradability, pore shape and sizes, and finely tunable chemical composition. MOFs have a rigid molecular structure, and tunable pore size can improve the encapsulation drug's stability under harsh conditions. Besides, the surface of MOFs can be modified with small-molecule ligands and biomolecule, and binding with the biomarkers which is overexpressed on the surface of cancer cells. MOFs formulations for therapeutic have been developed to effectively respond to the unique tumor microenvironment (TEM), such as high H2O2 levels, hypoxia, and high concentration glutathione (GSH). Thus, MOFs as a drug delivery system should avoid drugs leaking during blood circulation and releasing at the lesion sites via a controlling manner. In this article, we will summary environment responsive MOFs as drug delivery systems for tumor therapy under different stimuli.

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Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin

Acta Pharmaceutica ◽

10.2478/acph-2020-0012 ◽

2020 ◽

Vol 70 (1) ◽

pp. 77-88 ◽

Cited By ~ 4

Author(s):

Namfa Sermkaew ◽

Thipapun Plyduang

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Moringa Oleifera ◽

Delivery Systems ◽

Polyethylene Glycol 400 ◽

Peg 400 ◽

Enhanced Dissolution ◽

Promising Strategy ◽

Herbal Medicinal ◽

Percentage Ratio

AbstractThe aim of the present study was to develop self-microemulsifying drug delivery systems (SMEDDS) of the extract of Moringa oleifera, a herbal medicinal plant. Kaempferol and quercetin, the flavonoids present in the leaf extract of M. oleifera, were chosen as markers for quantification. The optimized formulation of SMEDDS consisted of propylene glycol dicaprylocaprate, polysorbate 80, and polyethylene glycol 400 (PEG 400) in a percentage ratio of 20:60:20 (m/m). SMEDDS emulsified immediately (within 20 s) after dilution in water, resulting in transparent microemulsions with a droplet size of 49 nm. SMEDDS could increase the solubility of kaempferol and quercetin to nearly 100 % within 15 min, whereas only a 30 % improvement in solubility was achieved in the case of crude extract. These results demonstrated SMEDDS to be a promising strategy to improve the solubility of M. oleifera extract-derived drugs, which, in turn, could prove beneficial to the herbal medicine field.

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Nanotechnology-based drug delivery systems for enhanced diagnosis and therapy of oral cancer

Journal of Materials Chemistry B ◽

10.1039/d0tb00957a ◽

2020 ◽

Vol 8 (38) ◽

pp. 8781-8793

Author(s):

Zhangfan Ding ◽

Krishna Sigdel ◽

Lei Yang ◽

Yunfei Liu ◽

Ming Xuan ◽

...

Keyword(s):

Drug Delivery ◽

Oral Cancer ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Diagnosis And Therapy ◽

Life Threatening

Oral cancer is a common malignant life-threatening tumor.

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Zeta potential changing self-emulsifying drug delivery systems utilizing a novel Janus-headed surfactant: A promising strategy for enhanced mucus permeation

Journal of Molecular Liquids ◽

10.1016/j.molliq.2019.111285 ◽

2019 ◽

Vol 291 ◽

pp. 111285 ◽

Cited By ~ 8

Author(s):

Faezeh Sharifi ◽

Imran Nazir ◽

Mulazim Hussain Asim ◽

Mansour Jahangiri ◽

Pedram Ebrahimnejad ◽

...

Keyword(s):

Drug Delivery ◽

Zeta Potential ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Promising Strategy

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Zeta potential changing self-emulsifying drug delivery systems: A promising strategy to sequentially overcome mucus and epithelial barrier

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2019.09.007 ◽

2019 ◽

Vol 144 ◽

pp. 40-49 ◽

Cited By ~ 11

Author(s):

Imran Nazir ◽

Andrea Fürst ◽

Noemi Lupo ◽

Andrea Hupfauf ◽

Ronald Gust ◽

...

Keyword(s):

Drug Delivery ◽

Zeta Potential ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Epithelial Barrier ◽

Promising Strategy

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Tumor-targeted Drug Delivery by Nanocomposites

Current Drug Metabolism ◽

10.2174/1389200221666200520092333 ◽

2020 ◽

Vol 21 (8) ◽

pp. 599-613 ◽

Cited By ~ 1

Author(s):

Abu Baker ◽

Mohd Salman Khan ◽

Muhammad Zafar Iqbal ◽

Mohd Sajid Khan

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Drug Delivery Systems ◽

Tumor Therapy ◽

Delivery Systems ◽

Great Achievement ◽

Tumor Environment ◽

Poorly Soluble ◽

Pharmaceutical Industries ◽

Stimuli Sensitive

Background: Tumor-targeted delivery by nanoparticles is a great achievement towards the use of highly effective drug at very low doses. The conventional development of tumor-targeted delivery by nanoparticles is based on enhanced permeability and retention (EPR) effect and endocytosis based on receptor-mediated are very demanding due to the biological and natural complications of tumors as well as the restrictions on the design of the accurate nanoparticle delivery systems. Methods: Different tumor environment stimuli are responsible for triggered multistage drug delivery systems (MSDDS) for tumor therapy and imaging. Physicochemical properties, such as size, hydrophobicity and potential transform by MSDDS because of the physiological blood circulation different, intracellular tumor environment. This system accomplishes tumor penetration, cellular uptake improved, discharge of drugs on accurate time, and endosomal discharge. Results: Maximum drug delivery by MSDDS mechanism to target therapeutic cells and also tumor tissues and sub cellular organism. Poorly soluble compounds and bioavailability issues have been faced by pharmaceutical industries, which are resolved by nanoparticle formulation. Conclusion: In our review, we illustrate different types of triggered moods and stimuli of the tumor environment, which help in smart multistage drug delivery systems by nanoparticles, basically a multi-stimuli sensitive delivery system, and elaborate their function, effects, and diagnosis.

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