Role of hepatokines in non-alcoholic fatty liver disease

Abstract Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic diseases like type 2 diabetes and obesity. In recent decades, accumulating evidence has revealed that the hepatokines, proteins mainly secreted by the liver, play important roles in the development of NAFLD by acting directly on the lipid and glucose metabolism. As a member of organokines, the hepatokines establish the communication between the liver and the adipose, muscular tissues. In this review, we summarize the current understanding of the hepatokines and how they modulate the pathogenesis of metabolic disorders especially NAFLD.

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Non-alcoholic fatty liver disease and metabolic syndrome in childhood

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-183-11-51-61 ◽

2020 ◽

Vol 183 (11) ◽

pp. 51-61

Author(s):

N. N. Vlasov ◽

E. A. Kornienko

Keyword(s):

Metabolic Syndrome ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Lifestyle Changes ◽

Alcoholic Fatty Liver ◽

Ample Evidence ◽

Alcoholic Fatty Liver Disease

There is ample evidence that insulin resistance, hyperinsulinemia, and obesity are at the heart of the development of non-alcoholic fatty liver disease (NAFLD). The disease is now considered as the hepatic component of metabolic syndrome (MS).64 children with NAFLD were assessed for metabolic syndrome stigma. An analysis was also made on the state of the problem according to the literature on the general links of the pathogenesis of these conditions, methods of diagnosis and treatment of NAFLD.All components of MS are observed with diﬀerent frequencies in patients with NAFD. This disease, together with type 2 diabetes mellitus, becomes very common diseases in childhood. The incidence of NAFLD in children is constantly growing, it has begun to occur in infants, an outcome in cirrhosis of the liver is possible within childhood, although the prognosis for NAFLD remains deﬁnitely uncertain. Weight loss with a low glycemic index diet, regular exercise, and other lifestyle changes are the mainstay of NAFLD treatment, but not yet very eﬀective for various reasons. In these conditions, it is necessary to increase the role of primary prevention of MS and NAFLD.

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Non-alcoholic fatty liver disease: the role of the nurse

Gastrointestinal Nursing ◽

10.12968/gasn.2020.18.sup6.s15 ◽

2020 ◽

Vol 18 (Sup6) ◽

pp. S15-S21

Author(s):

Lea Ladegaard Grønkjær ◽

Charlotte Wernberg ◽

Mette Munk Lauridsen

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Western World ◽

Alcoholic Fatty Liver ◽

Obesity Epidemic ◽

Adults And Children ◽

Alcoholic Fatty Liver Disease

Obesity is a frequent cause of morbidity in the Western world, and its prevalence has doubled since 1980. It is well known that conditions such as cardiovascular disease and type 2 diabetes can be serious consequences of obesity. However, less is known about whether the liver may also be affected by the obesity epidemic. Non-alcoholic fatty liver disease (NAFLD) is present in more than a quarter of the adult Western population, and the prevalence is increasing among both adults and children. NAFLD thus represents a common liver disease in the Western world. This is worrisome, because NAFLD can cause liver inflammation and various stages of fibrosis and eventually result in cirrhosis and hepatocellular carcinoma, which both have a high mortality rate due to related complications. Lifestyle change is the most important aspect in the prevention and treatment of NAFLD, and nurses play an important role in the early detection of NAFLD and the prevention of its possible progression.

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