Non-alcoholic fatty liver disease: the role of the nurse

2020 ◽  
Vol 18 (Sup6) ◽  
pp. S15-S21
Author(s):  
Lea Ladegaard Grønkjær ◽  
Charlotte Wernberg ◽  
Mette Munk Lauridsen
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Western World ◽  
Alcoholic Fatty Liver ◽  
Obesity Epidemic ◽  
Adults And Children ◽  
Alcoholic Fatty Liver Disease

Obesity is a frequent cause of morbidity in the Western world, and its prevalence has doubled since 1980. It is well known that conditions such as cardiovascular disease and type 2 diabetes can be serious consequences of obesity. However, less is known about whether the liver may also be affected by the obesity epidemic. Non-alcoholic fatty liver disease (NAFLD) is present in more than a quarter of the adult Western population, and the prevalence is increasing among both adults and children. NAFLD thus represents a common liver disease in the Western world. This is worrisome, because NAFLD can cause liver inflammation and various stages of fibrosis and eventually result in cirrhosis and hepatocellular carcinoma, which both have a high mortality rate due to related complications. Lifestyle change is the most important aspect in the prevention and treatment of NAFLD, and nurses play an important role in the early detection of NAFLD and the prevention of its possible progression.

scholarly journals Non-alcoholic fatty liver disease and metabolic syndrome in childhood

2020 ◽  
Vol 183 (11) ◽  
pp. 51-61
Author(s):  
N. N. Vlasov ◽  
E. A. Kornienko
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Lifestyle Changes ◽  
Alcoholic Fatty Liver ◽  
Ample Evidence ◽  
Alcoholic Fatty Liver Disease

There is ample evidence that insulin resistance, hyperinsulinemia, and obesity are at the heart of the development of non-alcoholic fatty liver disease (NAFLD). The disease is now considered as the hepatic component of metabolic syndrome (MS).64 children with NAFLD were assessed for metabolic syndrome stigma. An analysis was also made on the state of the problem according to the literature on the general links of the pathogenesis of these conditions, methods of diagnosis and treatment of NAFLD.All components of MS are observed with different frequencies in patients with NAFD. This disease, together with type 2 diabetes mellitus, becomes very common diseases in childhood. The incidence of NAFLD in children is constantly growing, it has begun to occur in infants, an outcome in cirrhosis of the liver is possible within childhood, although the prognosis for NAFLD remains definitely uncertain. Weight loss with a low glycemic index diet, regular exercise, and other lifestyle changes are the mainstay of NAFLD treatment, but not yet very effective for various reasons. In these conditions, it is necessary to increase the role of primary prevention of MS and NAFLD.

scholarly journals Role of Leptin in Non-Alcoholic Fatty Liver Disease

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 762
Author(s):  
Carlos Jiménez-Cortegana ◽  
Alba García-Galey ◽  
Malika Tami ◽  
Pilar del Pino ◽  
Isabel Carmona ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Energy Homeostasis ◽  
Public Health Problem ◽  
Calorie Intake ◽  
Alcoholic Fatty Liver ◽  
Adults And Children ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial health and economic burden in all countries, yet there is no approved pharmacotherapy to treat this entity, nor well-established strategies for its diagnosis. Its prevalence has been rapidly driven by increased physical inactivity, in addition to excessive calorie intake compared to energy expenditure, affecting both adults and children. The increase in the number of cases, together with the higher morbimortality that this disease entails with respect to the general population, makes NAFLD a serious public health problem. Closely related to the development of this disease, there is a hormone derived from adipocytes, leptin, which is involved in energy homeostasis and lipid metabolism. Numerous studies have verified the relationship between persistent hyperleptinemia and the development of steatosis, fibrinogenesis and liver carcinogenesis. Therefore, further studies of the role of leptin in the NAFLD spectrum could represent an advance in the management of this set of diseases.

scholarly journals Roles of Ceramides in Non-Alcoholic Fatty Liver Disease

2021 ◽  
Vol 10 (4) ◽  
pp. 792
Author(s):  
Eric Hajduch ◽  
Floriane Lachkar ◽  
Pascal Ferré ◽  
Fabienne Foufelle
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Hepatic Metabolism ◽  
Liver Fat ◽  
Alcoholic Fatty Liver ◽  
Obesity Epidemic ◽  
Lipid Species ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epidemic. Liver fat accumulation induces the synthesis of specific lipid species and particularly ceramides, a sphingolipid. In turn, ceramides have deleterious effects on hepatic metabolism, a phenomenon called lipotoxicity. We review here the evidence showing the role of ceramides in non-alcoholic fatty liver disease and the mechanisms underlying their effects.

scholarly journals Role of hepatokines in non-alcoholic fatty liver disease

2019 ◽  
Vol 7 (4) ◽  
pp. 143-148 ◽  
Author(s):  
Yini Ke ◽  
Chengfu Xu ◽  
Jin Lin ◽  
Youming Li
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Metabolic Diseases ◽  
Alcoholic Fatty Liver ◽  
Diabetes And Obesity ◽  
Alcoholic Fatty Liver Disease ◽  
Muscular Tissues

Abstract Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic diseases like type 2 diabetes and obesity. In recent decades, accumulating evidence has revealed that the hepatokines, proteins mainly secreted by the liver, play important roles in the development of NAFLD by acting directly on the lipid and glucose metabolism. As a member of organokines, the hepatokines establish the communication between the liver and the adipose, muscular tissues. In this review, we summarize the current understanding of the hepatokines and how they modulate the pathogenesis of metabolic disorders especially NAFLD.

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