Modern Ways of Treatment of Metabolic Disorders in Women with Polycystic Ovarian Syndrome

Abstract Article represents complex approach to PCOS problem from the position of prophylaxis and therapy of metabolic disorders, which include overweight and obesity, insulin resistance, carbohydrate and lipid metabolism deviations. Lifestyle modification specifically including healthy diet was provided as an example. Also, were described medications, which increase insulin sensitivity and method of treatment in case of 3rd class obesity.

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Women with polycystic ovarian syndrome and elevated levels of insulin resistance are more prone to benefit from diets to improve insulin sensitivity: a meta-analysis

Fertility and Sterility ◽

10.1016/j.fertnstert.2019.07.1109 ◽

2019 ◽

Vol 112 (3) ◽

pp. e388

Author(s):

Esther López-Bayghen ◽

Samantha García-Hernandez ◽

M. Elba Gonzalez-Mejia ◽

Leonardo M. Porchia

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Polycystic Ovarian Syndrome ◽

Meta Analysis ◽

Improve Insulin Sensitivity ◽

Ovarian Syndrome

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Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

10.21203/rs.3.rs-395007/v1 ◽

2021 ◽

Author(s):

Muhammad Aliff Haslan ◽

Nurdiana Samsulrizal ◽

Nooraain Hashim ◽

Noor Syaffinaz Noor Mohamad Zin ◽

Farshad Hosseini Shirazi ◽

...

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Normal Control ◽

Polycystic Ovarian Syndrome ◽

Density Lipoprotein ◽

Female Rats ◽

Lipoprotein Cholesterol ◽

Therapeutic Effects ◽

Ficus Deltoidea ◽

Ovarian Syndrome

Abstract Background: Insulin resistance and hormonal imbalances are key features in the pathophysiology of polycystic ovarian syndrome (PCOS). We have shown that Ficus deltoidea var. deltoidea Jack (Moraceae) can improve insulin sensitivity and hormonal profile in PCOS female rats. However, biological characteristics underpinning the therapeutic effects of F. deltoidea for treating PCOS remain to be clarified. This study aims to investigate the biochemical, hormonal, and histomorphometric changes in letrozole (LTZ)-induced PCOS female rats following treatment with F. deltoidea.Methods: PCOS was induced in rats except for normal control by administering LTZ at 1 mg/kg/day for 21 days. Methanolic extract of F. deltoidea leaf was then orally administered to the PCOS rats at the dose of 250, 500, or 1000 mg/kg/day, respectively for 15 consecutive days. Lipid profile was measured enzymatically in serum. The circulating concentrations of reproductive hormone and antioxidant enzymes were determined by ELISA assays. Ovarian and uterus histomorphometric changes were further observed by hematoxylin and eosin (H&E) staining.Results: The results showed that treatment with F. deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats. The levels of high-density lipoprotein cholesterol (HDL), estrogen, and superoxide dismutase (SOD) also similar to those observed in normal control rats. Histomorphometric measurements confirmed that F. deltoidea increased the corpus luteum number and the endometrial thickness.Conclusions: F. deltoidea can reverse PCOS symptoms in female rats by improving insulin sensitivity, antioxidant activities, hormonal imbalance, and histological changes. These findings suggest the potential use of F. deltoidea as an adjuvant agent in the treatment program of PCOS.

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The Insulin-Sensitive Side of SHIP2

The Scientific World JOURNAL ◽

10.1100/tsw.2001.34 ◽

2001 ◽

Vol 1 ◽

pp. 209-210

Author(s):

Stephane Schurmans

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Type Ii Diabetes ◽

Polycystic Ovarian Syndrome ◽

Type Ii ◽

Obesity Hypertension ◽

Ovarian Syndrome ◽

The Eu

A substantial and increasing proportion of death and disability in the EU (and elsewhere) is attributable to diseases associated with insulin resistance (i.e., decreased insulin sensitivity). Beside type II diabetes, other diseases like obesity, hypertension, atherosclerosis, hyperlipidaemia, polycystic ovarian syndrome, and acromegaly are indeed associated with insulin resistance [1].

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Is serum amylase normal in women with polycystic ovarian syndrome?

Baghdad Science Journal ◽

10.21123/bsj.11.4.1583-1591 ◽

2014 ◽

Vol 11 (4) ◽

pp. 1583-1591

Author(s):

Baghdad Science Journal

Keyword(s):

Insulin Resistance ◽

Metabolic Disorders ◽

Polycystic Ovarian Syndrome ◽

Serum Amylase ◽

Amylase Activity ◽

Polycystic Ovary ◽

Reproductive Age ◽

Ovary Syndrome ◽

Reproductive Age Women ◽

Ovarian Syndrome

Background : Polycystic ovary syndrome (PCOS) is the most common cause of infertility in reproductive-age women , it is an important harbinger of metabolic disorders. It has been reported that hyperamylasemia can be used as marker of ovarian cancer patients . The current study was conducted to evaluate amylase activity and to estimate the correlation of this enzyme with insulin and insulin resistance in PCOS patients. Methods: This study was conducted on forty five patients with PCOS in comparison to twenty five women as control. Fasting blood sample was taken from each subject and analyzed for amylase activity , FSH,LH, Insulin , proteins, and blood sugar , meanwhile insulin resistance was determined by HOMA-IR index. Results: The results of the study showed a significant increase (p

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Association of Thyroid Stimulating Hormone with Insulin Resistance in Women with Polycystic Ovarian Syndrome

Journal of Armed Forces Medical College Bangladesh ◽

10.3329/jafmc.v11i1.30676 ◽

2016 ◽

Vol 11 (1) ◽

pp. 69-73

Author(s):

Salma Naher ◽

Sultana Rajia Begum ◽

Liaquat Ali ◽

Maksumul Hakim

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Subclinical Hypothyroidism ◽

Polycystic Ovarian Syndrome ◽

Thyroid Stimulating Hormone ◽

Model Assessment ◽

C Peptide ◽

Ovarian Syndrome ◽

Serum Tsh ◽

Stimulating Hormone

Introduction: Polycystic Ovarian Syndrome (PCOS) is a major cause of female infertility which is thought to be associated with Insulin Resistance (IR). However the nature and degree of IR have been shown to vary in different populations. PCOS women have also been reported to have increased prevalence of subclinical hypothyroidism which has been postulated to be determinants of IR. The natures of thyroid involvement have also been shown to vary between populations.Objectives: The study was undertaken to explore the distribution of IR and thyroid dysfunction as assessed by Thyroid Stimulating Hormone (TSH) levels among PCOS subjects and also to investigate the association of IR with TSH in women with PCOS.Materials and Methods: One hundred and fifty one PCOS patients (age in years 24±5; M±SD) were studied. PCOS was diagnosed by Rotterdam criteria. Fasting serum C-peptide was measured by Enzyme Linked Immuno Sorbide Essay (ELISA) and serum TSH was measured by Microparticle Enzyme Immunoassay (MEIA). Serum glucose was estimated by Glucose-Oxidase method (GOD-PAP). Insulin sensitivity was assessed by using Homeostasis Model Assessment (HOMA).Results: The mean serum C-peptide (nmol/l) and HOMA%S were 0.67 (±0.35) and 85 (±42) respectively. The median (Range) serum TSH level (?lU/ml) of the study subjects was found to be 2.49 (0.66 to 20.86). Insulin sensitivity was found to be 26%, 47%, 17% and 10% in those who had HOMA%S level at the range of <50, 50-100, 101-150 and >150 respectively. Of the total PCOS subjects, 85% had normal level of TSH value whereas only 15% PCOS subjects had subclinical hypothyroidism. The median serum TSH level of the insulin resistance and non-resistance groups were 2.25 (0.89-5.71) and 2.58 (0.74-20.86) respectively. On Pearson's correlation analysis insulin sensitivity was not found to be any significant association with TSH in the PCOS subjects.Conclusion: The study revealed that there was no significant association with IR and TSH in the PCOS subjects.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 69-73

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Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-021-03452-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Muhammad Aliff Haslan ◽

Nurdiana Samsulrizal ◽

Nooraain Hashim ◽

Noor Syaffinaz Noor Mohamad Zin ◽

Farshad H. Shirazi ◽

...

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Normal Control ◽

Polycystic Ovarian Syndrome ◽

Density Lipoprotein ◽

Female Rats ◽

Lipoprotein Cholesterol ◽

Therapeutic Effects ◽

Ficus Deltoidea ◽

Ovarian Syndrome

Abstract Background Insulin resistance and hormonal imbalances are key features in the pathophysiology of polycystic ovarian syndrome (PCOS). We have previously shown that Ficus deltoidea var. deltoidea Jack (Moraceae) can improve insulin sensitivity and hormonal profile in PCOS female rats. However, biological characteristics underpinning the therapeutic effects of F. deltoidea for treating PCOS remain to be clarified. This study aims to investigate the biochemical, hormonal, and histomorphometric changes in letrozole (LTZ)-induced PCOS female rats following treatment with F. deltoidea. Methods PCOS was induced in rats except for normal control by administering LTZ at 1 mg/kg/day for 21 days. Methanolic extract of F. deltoidea leaf was then orally administered to the PCOS rats at the dose of 250, 500, or 1000 mg/kg/day, respectively for 15 consecutive days. Lipid profile was measured enzymatically in serum. The circulating concentrations of reproductive hormone and antioxidant enzymes were determined by ELISA assays. Ovarian and uterus histomorphometric changes were further observed by hematoxylin and eosin (H&E) staining. Results The results showed that treatment with F. deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats. The levels of high-density lipoprotein cholesterol (HDL), estrogen, and superoxide dismutase (SOD) are also similar to those observed in normal control rats. Histomorphometric measurements confirmed that F. deltoidea increased the corpus luteum number and the endometrial thickness. Conclusions F. deltoidea can reverse PCOS symptoms in female rats by improving insulin sensitivity, antioxidant activities, hormonal imbalance, and histological changes. These findings suggest the potential use of F. deltoidea as an adjuvant agent in the treatment program of PCOS.

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