scholarly journals Imaging Diagnosis of a Proximal Tibia Tumor – Case Presentation

2018 ◽  
Vol 1 (Supplement) ◽  
pp. 36
Author(s):  
R. Turcu ◽  
A. Barbilian

Abstract Introduction. 30 years ago, the primary role of radiology in tumor pathology was predominant in establishing the diagnosis. A wide range of techniques has been developed, allowing the interventionist radiologist to apply new procedures to patients with tumor pathology. This improved both the diagnosis and the treatment of tumor lesions. Material and method. A 19-year-old male patient, accused pain and functional knee failure, and pain in the ipsilateral ankle, which started about three months before, because of a sprain. Following the clinical examination, a suspicion of a meniscal lesion associated with a lesion of the ankle ligament complex arose. The magnetic resonance imaging revealed the meniscal lesion, but changes in the proximal tibia were observed, which required computed tomography of the knee. The presence of an osseous tumor at the proximal tibia was revealed. Given the unpredictable evolution of tumors in young people, a bone scintigraphy was decided to be performed. Results. The imaging studies commonly used in assessing the patient with musculoskeletal tumor pathology are radiographs, nuclear magnetic resonance, computed tomography, bone scintigraphy. Magnetic resonance imaging is the most sensitive method of diagnosis, allowing the assessment of the extent of the tumor formation in the medullary canal, but also in the adjacent soft tissues. Conclusion. After analyzing the patient’s history, the clinical, paraclinical and imaging examination, and the differential diagnosis will be established and the optimal treatment will be decided in this case.

2018 ◽  
Vol 1 (Supplement) ◽  
pp. 39
Author(s):  
R. Turcu ◽  
A. Barbilian

Abstract Introduction. The most common and used molecular imaging techniques used in tumor pathology are the following: optics such as fluoroscopy, bioluminescence, and spectroscopy, radionuclides such as positron emission computed tomography, magnetic resonance with or without contrast substance, ultrasound and computed tomography. Material and method. A 39-year-old male patient accused having a shoulder tumor beginning 6 months before with a slow increase in volume without symptoms, pain, local temperature changes, and neurological phenomena. The clinical examination revealed the presence of an elastic consistency tumor, adherent to the bone but movable in soft adjacent tissues, without spontaneous and palpation pain, and local swelling. There was a slight functional embarrassment in conducting the abduction maneuver, but without limiting the amplitude of the movement. Results. Radiography of the shoulder did not reveal any significant changes. Magnetic resonance imaging of the shoulder and contrast-enhanced magnetic resonance imaging of the shoulder were performed. The evoked changes required a computed tomography of the shoulder. Conclusion. The thorough analysis of the imaging investigations and the clinical, paraclinical, and biological context of the patient will lead to the indication of the treatment and the optimal surgical time.


2016 ◽  
Vol 18 (3) ◽  
pp. 378 ◽  
Author(s):  
Talita Micheletti Helfer ◽  
Alberto Borges Peixoto ◽  
Gabriele Tonni ◽  
Edward Araujo Júnior

Craniosynostosis is defined as the process of premature fusion of one or more of the cranial sutures.  It is a common condition that occurs in about 1 to 2,000 live births. Craniosynostosis may be classified in primary or secondary. It is also classified as nonsyndromic or syndromic. According to suture commitment, craniosynostosis may affect a single suture or multiple sutures. There is a wide range of syndromes involving craniosynostosis and the most common are Apert, Pffeifer, Crouzon, Shaethre-Chotzen and Muenke syndromes. The underlying etiology of nonsyndromic craniosynostosis is unknown. Mutations in the fibroblast growth factor (FGF) signalling pathway play a crucial role in the etiology of craniosynostosis syndromes. Prenatal ultrasound`s detection rate of craniosynostosis is low. Nowadays, different methods can be applied for prenatal diagnosis of craniosynostosis, such as two-dimensional (2D) and three-dimensional (3D) ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) scan and, finally, molecular diagnosis. The presence of craniosynostosis may affect the birthing process. Fetuses with craniosynostosis also have higher rates of perinatal complications. In order to avoid the risks of untreated craniosynostosis, children are usually treated surgically soon after postnatal diagnosis.


Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 230
Author(s):  
Oleksandr Shapoval ◽  
Viktoriia Oleksa ◽  
Miroslav Šlouf ◽  
Volodymyr Lobaz ◽  
Olga Trhlíková ◽  
...  

Multimodal imaging, integrating several modalities including down- and up-conversion luminescence, T1- and T2(T2*)-weighted MRI, and CT contrasting in one system, is very promising for improved diagnosis of severe medical disorders. To reach the goal, it is necessary to develop suitable nanoparticles that are highly colloidally stable in biologically relevant media. Here, hydrophilic poly(N,N-dimethylacrylamide-N-acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer. The particles were tho-roughly characterized by a dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray energy dispersive spectroscopy (EDAX), selected area electron diffraction (SAED), elemental ana-lysis and fluorescence spectroscopy. Aqueous particle dispersions exhibited excellent colloidal stability in water and physiological buffers. In vitro toxicity assessments suggested no or only mild toxicity of the surface-engineered Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ particles in a wide range of concentrations. Internalization of the particles by several types of cells, including HeLa, HF, HepG2, and INS, was confirmed by a down- and up-conversion confocal microscopy. Newly developed particles thus proved to be an efficient contrast agent for fluorescence imaging, T1- and T2(T2*)-weighted magnetic resonance imaging (MRI), and computed tomography (CT).


2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Maimoona Siddique ◽  
Humayun Bashir ◽  
Imran K Niazi ◽  
Ahsan Shamim

An 11-year-old boy presented with painful swelling of leg following fracture of tibia. Osteo brous dysplasia (OFD) is an uncommon, benign, non-hereditary bone disorder in which brous tissue develops in place of normal bone that affects the young adults in their rst and second decade of life. Tc-99m MDP whole-body bone scintigraphy revealed increased tracer uptake in dense proximal tibia. On single-photon remission computed tomography-computed tomography (SPECT-CT), radiological features of cortical-based lesion superimposed on abnormal tracer uptake con rmed it to be a monostotic OFD. This case emphasises the role of SPECT-CT and magnetic resonance imaging in detecting osteo brous dysplasia and differentiating it from other benign bone conditions. Key words: Bone scintigraphy, magnetic resonance imaging, monostotic osteo brous dysplasia, single-photon emission computed tomography computed tomography, tibia


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