Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography

Multimodal imaging, integrating several modalities including down- and up-conversion luminescence, T1- and T2(T2*)-weighted MRI, and CT contrasting in one system, is very promising for improved diagnosis of severe medical disorders. To reach the goal, it is necessary to develop suitable nanoparticles that are highly colloidally stable in biologically relevant media. Here, hydrophilic poly(N,N-dimethylacrylamide-N-acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer. The particles were tho-roughly characterized by a dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray energy dispersive spectroscopy (EDAX), selected area electron diffraction (SAED), elemental ana-lysis and fluorescence spectroscopy. Aqueous particle dispersions exhibited excellent colloidal stability in water and physiological buffers. In vitro toxicity assessments suggested no or only mild toxicity of the surface-engineered Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ particles in a wide range of concentrations. Internalization of the particles by several types of cells, including HeLa, HF, HepG2, and INS, was confirmed by a down- and up-conversion confocal microscopy. Newly developed particles thus proved to be an efficient contrast agent for fluorescence imaging, T1- and T2(T2*)-weighted magnetic resonance imaging (MRI), and computed tomography (CT).

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Fabrication of a dual T1 and T2 contrast agent for magnetic resonance imaging using cellulose nanocrystals/Fe3O4 nanocomposite

European Polymer Journal ◽

10.1016/j.eurpolymj.2019.05.048 ◽

2019 ◽

Vol 118 ◽

pp. 128-136 ◽

Cited By ~ 5

Author(s):

Narges Torkashvand ◽

Nahid Sarlak

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Contrast Agent ◽

Cellulose Nanocrystals ◽

Resonance Imaging ◽

T1 And T2

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Ultrafine graphene oxide–CoFe2O4 nanoparticle composite as T1 and T2 contrast agent for magnetic resonance imaging

RSC Advances ◽

10.1039/c5ra27186j ◽

2016 ◽

Vol 6 (21) ◽

pp. 17423-17429 ◽

Cited By ~ 6

Author(s):

N. Venkatesha ◽

Pavan Poojar ◽

R. Ashwini ◽

Yasrib Qurishi ◽

Sairam Geethanath ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Graphene Oxide ◽

Magnetic Resonance ◽

Contrast Agent ◽

Synthesis Method ◽

Resonance Imaging ◽

T1 And T2 ◽

Nanoparticle Composites

Graphene oxide–CoFe2O4 nanoparticle composites were synthesized using a two step synthesis method in which graphene oxide was initially synthesized followed by precipitation of CoFe2O4 nanoparticles in a reaction mixture containing graphene oxide.

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Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent

Applied Sciences ◽

10.3390/app11178222 ◽

2021 ◽

Vol 11 (17) ◽

pp. 8222

Author(s):

Shanti Marasini ◽

Huan Yue ◽

Adibehalsadat Ghazanfari ◽

Son Long Ho ◽

Ji Ae Park ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Contrast Agent ◽

Contrast Agents ◽

Proton Spin ◽

Water Proton ◽

Resonance Imaging ◽

Polyaspartic Acid ◽

Mri Contrast ◽

T1 And T2

Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2/r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

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Craniosynostosis: prenatal diagnosis by 2D/3D ultrasound, magnetic resonance imaging and computed tomography.

Medical Ultrasonography ◽

10.11152/mu.2013.2066.183.3du ◽

2016 ◽

Vol 18 (3) ◽

pp. 378 ◽

Cited By ~ 16

Author(s):

Talita Micheletti Helfer ◽

Alberto Borges Peixoto ◽

Gabriele Tonni ◽

Edward Araujo Júnior

Keyword(s):

Magnetic Resonance Imaging ◽

Computed Tomography ◽

Prenatal Diagnosis ◽

Magnetic Resonance ◽

Three Dimensional ◽

3D Ultrasound ◽

Resonance Imaging ◽

Perinatal Complications ◽

Wide Range ◽

Magnetic Resonance Imaging Mri

Craniosynostosis is defined as the process of premature fusion of one or more of the cranial sutures. It is a common condition that occurs in about 1 to 2,000 live births. Craniosynostosis may be classified in primary or secondary. It is also classified as nonsyndromic or syndromic. According to suture commitment, craniosynostosis may affect a single suture or multiple sutures. There is a wide range of syndromes involving craniosynostosis and the most common are Apert, Pffeifer, Crouzon, Shaethre-Chotzen and Muenke syndromes. The underlying etiology of nonsyndromic craniosynostosis is unknown. Mutations in the fibroblast growth factor (FGF) signalling pathway play a crucial role in the etiology of craniosynostosis syndromes. Prenatal ultrasound`s detection rate of craniosynostosis is low. Nowadays, different methods can be applied for prenatal diagnosis of craniosynostosis, such as two-dimensional (2D) and three-dimensional (3D) ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) scan and, finally, molecular diagnosis. The presence of craniosynostosis may affect the birthing process. Fetuses with craniosynostosis also have higher rates of perinatal complications. In order to avoid the risks of untreated craniosynostosis, children are usually treated surgically soon after postnatal diagnosis.

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Investigation of the potential of using TiO2 nanoparticles as a contrast agent in computed tomography and magnetic resonance imaging

Applied Nanoscience ◽

10.1007/s13204-019-01098-y ◽

2019 ◽

Vol 10 (8) ◽

pp. 3143-3148 ◽

Cited By ~ 4

Author(s):

Hiroaki Akasaka ◽

Naritoshi Mukumoto ◽

Masao Nakayama ◽

Tianyuan Wang ◽

Ryuichi Yada ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Computed Tomography ◽

Magnetic Resonance ◽

Contrast Agent ◽

Tio2 Nanoparticles ◽

Resonance Imaging

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A New Potential Contrast Agent for Magnetic Resonance Imaging: Iron Oxide-4A Nanocomposite

Journal of Biomedical Physics and Engineering ◽

10.31661/jbpe.v0i0.755 ◽

2019 ◽

Cited By ~ 1

Author(s):

L Zareei ◽

B Divband ◽

A Mesbahi ◽

M Khatamian ◽

A Kiani ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Iron Oxide ◽

Magnetic Resonance ◽

Contrast Agent ◽

Contrast Agents ◽

Particle Diameter ◽

Average Particle ◽

Relaxation Rates ◽

Resonance Imaging ◽

T1 And T2

Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent.Materials and Methods: Iron oxide–4A nanocomposite (F4A) was synthesized. MTT assay was used to consider the nanocomposite safety for cell culture. The T1 and T2 relaxation times were measured using a 1.5 Tesla clinical MRI scanner. Then the corresponding relaxivities were determined.Results: The average particle diameter of the nanocomposite was 50 to 100 nm based on scanning electron microscope (SEM) image. A linear relationship between relaxation rates and the Fe concentration of the nanocomposite was obtained. The T1 and T2 relaxivities of the nanocomposite were calculated 5.413 and 1092.1 mM-1.s-1, respectively which led to the T2/T1 relaxivity ratioof 201.75.Conclusion: The high T2/T1 relaxivity ratio of the iron oxide–4A nanocomposite confirms it’s potential to act as a T2 contrast agent.

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