Differential pulse adsorptive stripping voltammetric determination of methotrexate using a functionalized carbon nanotubes-modified glassy carbon electrode

AbstractA glassy carbon electrode (GC) containing multiwalled functionalized carbon nanotubes (MWCNTs) immobilized within a dihexadecylhydrogenphosphate film (DHP) is proposed as a nanostructured platform for determination of methotrexate (MTX) concentration (a drug used in cancer treatment) using differential pulse adsorptive stripping voltammetry (DPAdSV). The voltammograms for a MTX solution using MWCNTs-DHP/GC electrode presented an oxidation peak potential at 0.98 V vs. Ag/AgCl (3.0 mol L−1 KCl) in a 0.1 mol L−1 sulphuric acid. The apparent heterogeneous electron transfer rate constant of 0.46 s−1 was calculated. The recovery area of 2.62×10−9 mol cm2 was also obtained. Under the optimal experimental conditions, the analytical curve was linear in the MTX concentration range from 5.0×10−8 to 5.0×10−6 mol L−1, with a detection limit of 3.3×10−8 mol L−1. The MWCNTs-DHP/GC electrode can be easily prepared and was applied for the determination of MTX in pharmaceutical formulations, with results similar to those obtained using a high-performance liquid chromatography comparative method.

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Differential pulse voltammetric determination of ciprofibrate in pharmaceutical formulations using a glassy carbon electrode modified with functionalized carbon nanotubes within a poly(allylamine hydrochloride) film

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2011.11.028 ◽

2012 ◽

Vol 161 (1) ◽

pp. 755-760 ◽

Cited By ~ 17

Author(s):

Humberto H. Takeda ◽

Bruno C. Janegitz ◽

Roberta A. Medeiros ◽

Luiz H.C. Mattoso ◽

Orlando Fatibello-Filho

Keyword(s):

Carbon Nanotubes ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Pharmaceutical Formulations ◽

Differential Pulse ◽

Voltammetric Determination ◽

Carbon Electrode ◽

Functionalized Carbon Nanotubes ◽

Allylamine Hydrochloride

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Glassy Carbon Electrode Modified with Functionalized Carbon Nanotubes Within a Poly(allylamine hydrochloride) Film for the Voltammetric Determination of Sulfite in Foods

Electroanalysis ◽

10.1002/elan.201100122 ◽

2011 ◽

Vol 23 (11) ◽

pp. 2526-2533 ◽

Cited By ~ 23

Author(s):

Elen Romão Sartori ◽

Humberto Hissashi Takeda ◽

Orlando Fatibello-Filho

Keyword(s):

Carbon Nanotubes ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Voltammetric Determination ◽

Carbon Electrode ◽

Functionalized Carbon Nanotubes ◽

Allylamine Hydrochloride

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The Application of Glassy Carbon Electrode Modified by Multi-Walled Carbon Nanotubes for the Fast Determination of Hydroquinone in Wastewater

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.955-959.1160 ◽

2014 ◽

Vol 955-959 ◽

pp. 1160-1166

Author(s):

Shao Hua Li ◽

Ying Ying Zhao ◽

Jun Qing Yang ◽

Guo Yan Zhang ◽

Ju Rui Qi

Keyword(s):

Carbon Nanotubes ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Phosphate Buffer Solution ◽

Differential Pulse ◽

Carbon Electrode ◽

Buffer Solution ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

A novel multi-walled carbon nanotubes (MWCNTs)-modified glassy carbon electrode (GCE) with excellent stability, repeatability and anti-interference was synthesized and it exhibited an electrocatalytic signal for hydroquinone (HQ) compared to bare GCE, which suggested that the presence of MWCNTs efficiently enhances electron transfer. Various parameters such as pH, modifier volume, and scan rate were optimized using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. Under optimum conditions, linear responses for HQ in 0.1mol·L-1 phosphate buffer solution of pH 6.0 were obtained in the range of 5×10-6 mol·L-1 to 2×10-4 mol·L-1 with detection limits of 2.7×10-6 mol·L-1 (signal-to-noise ratio of 3). Such MWCNTs-modified GCE was successfully applied for the determination of hydroquinone in simulated water samples and can be developed for the the detection of HQ.

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Differential pulse anodic stripping voltammetric determination of Cd and Pb at a bismuth glassy carbon electrode modified with Nafion, poly(2,5-dimercapto-1,3,4-thiadiazole) and multiwalled carbon nanotubes

Microchimica Acta ◽

10.1007/s00604-010-0541-8 ◽

2011 ◽

Vol 173 (1-2) ◽

pp. 95-102 ◽

Cited By ~ 39

Author(s):

Xiuhui He ◽

Zhaohong Su ◽

Qingji Xie ◽

Chao Chen ◽

Yingchun Fu ◽

...

Keyword(s):

Carbon Nanotubes ◽

Multiwalled Carbon Nanotubes ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Differential Pulse ◽

Voltammetric Determination ◽

Carbon Electrode ◽

Multiwalled Carbon ◽

Anodic Stripping

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Adsorptive anodic stripping differential pulse voltammetric determination of CellCept at Fe 3 O 4 nanoparticles decorated multi-walled carbon nanotubes modified glassy carbon electrode

Analytical Biochemistry ◽

10.1016/j.ab.2016.12.019 ◽

2017 ◽

Vol 520 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Mohammad Bagher Gholivand ◽

Mohammad Solgi

Keyword(s):

Carbon Nanotubes ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Differential Pulse ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Anodic Stripping ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

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Multiwall Carbon Nanotubes-Modified Glassy Carbon Electrode for Square-Wave Stripping Voltammetric Determination of Aqueous Antimony (III) Ion

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.518-523.1571 ◽

2012 ◽

Vol 518-523 ◽

pp. 1571-1575 ◽

Cited By ~ 4

Author(s):

Yao Guang Guo ◽

Wei Yan ◽

Xiao Yi Lou ◽

Dong Xue Xiao ◽

Ping Zhai ◽

...

Keyword(s):

Carbon Nanotubes ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Multiwall Carbon Nanotubes ◽

Deposition Potential ◽

Carbon Electrode ◽

Experimental Conditions ◽

Square Wave ◽

Multiwall Carbon

A glassy carbon electrode (GCE) modified with multiwall carbon nanotubes (MWCNTs) for electrochemical square-wave stripping voltammetric (SWV) determination of antimony (III) was introduced. Various experimental parameters, such as the amounts of carbon nanotubes, the deposition potential and time, the electrolyte solution, etc, were thoroughly optimized and discussed. Under the optimum experimental conditions, the MWCNTs-modified GCE exhibited well linear behaviour in the antimony(III) concentration range from 0.04 to 0.26 mg/L (R=0.9983) with a detection limit of 3.20×10-4mg/L (S/N=3) under a 360 s accumulation. The proposed electrode also exhibited encouraging properties for measurements of simulated water samples.

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