scholarly journals Lactic acidosis occurrence during exercises in the smoke chamber in a 53-year-old firefighter with no significant medical history

2014 ◽  
Vol 27 (2) ◽  
Author(s):  
Agata Bronisz ◽  
Magdalena Spychalska ◽  
Małgorzata Szafrańska
Keyword(s):  
Cardiovascular Disease ◽  
Lactic Acidosis ◽  
Systemic Diseases ◽  
Lactic Acid Concentration ◽  
Arterial Blood ◽  
Blood Ph ◽  
Acquired Immunodeficiency ◽  
Smoke Chamber ◽  
Reduced Rate ◽  
Immunodeficiency Syndrome

AbstractLactic acidosis is a form of metabolic acidosis with a high anion gap, reduced rate of arterial blood pH under 7.35 mmol/l, and lactic acid concentration over 7 mmol/l. In the literature we can find some descriptions of the cases of lactic acidosis in patients with severe systemic diseases (cancer, acquired immunodeficiency syndrome, sepsis, diabetes with cardiovascular disease and after organ transplantations). We present the case of lactic acidosis in a patient with no chronic disease — a firefighter in whom lactic acidosis has developed during standard exercises in the smoke chamber.

Cardiovascular disease: the new epidemic in sub-Saharan Africa

Vascular ◽  
2011 ◽  
Vol 19 (6) ◽  
pp. 301-307 ◽  
Author(s):  
Ifechukwude Ikem ◽  
Bauer E Sumpio
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Sub Saharan Africa ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Double Burden ◽  
The Usa ◽  
Acquired Immunodeficiency ◽  
Sub Saharan ◽  
Immunodeficiency Syndrome

Sub-Saharan Africa (SSA) is now facing a double burden of disease where patients are suffering from non-communicable diseases such as coronary heart disease, along with the burden of the current human immunodeficiency virus (HIV) epidemic. Due to this double burden, cardiovascular disease (CVD) prevention and treatment has been overlooked, allowing the rates to continue to rise unchecked. A series of searches were conducted using PubMed as the primary database. From these searches, journal articles were compiled that related to diabetes, obesity and smoking rates in SSA. Also, the prevalence of CVD in the USA was reviewed. Although the USA has higher rates of CVD now, the rates were on the decline compared with SSA. Due to ‘Westernization’ of SSA, the rates of CVD risk factors, such as diabetes, are expected to increase by 50%. Because of this, 80% of CVD deaths worldwide took place in developing countries like those in SSA. Although HIV/acquired immunodeficiency syndrome (AIDS) is the current epidemic in SSA, CVD disease poses a threat as the new epidemic because of the increasing rates of these CVD risk factors. Without combating this disease now, SSA is facing an epidemiological shift from AIDS to CVD being the leading cause of death.

scholarly journals Fatal Lactic Acidosis in a Patient with Acquired Immunodeficiency Syndrome Treated with Stavudine, Lamivudine and Indinavir

1999 ◽  
Vol 73 (12) ◽  
pp. 1232-1235 ◽  
Author(s):  
Ken TANAKA ◽  
Shigeki FUKAHORI ◽  
Hiroto JOJIMA ◽  
Yukiko FUJIMATSU ◽  
Kaori SHIRAISHI ◽  
...  
Keyword(s):  
Lactic Acidosis ◽  
Acquired Immunodeficiency Syndrome ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

scholarly journals Chronic lactic acidosis in a patient with acquired immunodeficiency syndrome and mitochondrial myopathy: biochemical studies.

1992 ◽  
Vol 3 (6) ◽  
pp. 1212-1219
Author(s):  
R Gopinath ◽  
M Hutcheon ◽  
S Cheema-Dhadli ◽  
M Halperin
Keyword(s):  
Lactic Acid ◽  
Liver Function ◽  
Lactic Acidosis ◽  
Acquired Immunodeficiency Syndrome ◽  
Mitochondrial Myopathy ◽  
Liver Function Tests ◽  
Rapid Rate ◽  
Biochemical Studies ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

A 30-yr-old man with acquired immunodeficiency syndrome treated with zidovudine developed biopsy-proven mitochondrial myopathy. Chronic lactic acidosis (lactate, 10 +/- 1 mmol/L) persisted for more than 5 wk. Liver function tests were normal, but the concentration of lactose rose to 16.1 mmol/L when 500 mmol of ethanol was infused. The concentration of lactose rose by only 1.5 mmol/L with maximally tolerated exercise. If this mitochondrial lesion compromised flux through the electron transport system, increased turnover of ATP with exercise should have exacerbated the degree of lactic acidosis because of increased need to regenerate ATP via glycolysis. Two possible explanations will be discussed: first, there was both a rapid rate of production of lactic acid in affected muscles in conjunction and an equally rapid rate of removal by uninvolved organs. Second, there was a low net rate of production of lactic acid in involved muscles despite the exercise.

Lactic Acidosis in Channel Catfish

1968 ◽  
Vol 25 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Charles W. Caillouet Jr.
Keyword(s):  
Lactic Acid ◽  
Lactic Acidosis ◽  
Respiratory Rate ◽  
Acid Concentration ◽  
Ictalurus Punctatus ◽  
Channel Catfish ◽  
Lactic Acid Concentration ◽  
Blood Ph

Channel catfish (Ictalurus punctatus) were subjected to 5 or 10 min of anoxia (removed from water) to rapidly increase blood lactic acid concentration metabolically. Blood pH decreased as blood lactic acid concentration increased. Respiratory rate increased in fish with lowered blood pH and with increased blood lactic acid concentration during the 10 min after fish were returned to water after anoxia. Fish not treated had a mean blood pH of 7.8. Blood pH decreased in catfish subjected to anoxia 5, 10, and 15 min and decreased further when the fish were returned to water. Lowered blood pH was associated with loss of equilibrium and death in catfish subjected to transportation and handling.

Immunogold labeling of Pneumocystis carinii for Electron microscopy

1991 ◽  
Vol 49 ◽  
pp. 270-271
Author(s):  
Michael P. Goheen ◽  
Marilyn S. Bartlett ◽  
James W. Smith
Keyword(s):  
Electron Microscopy ◽  
Pneumocystis Carinii ◽  
Severe Pneumonia ◽  
Culture Fluid ◽  
Immunogold Labeling ◽  
Antigenic Sites ◽  
Transmission Electron ◽  
Response To Chemotherapy ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Studies of the biology of Pneumocystis carinii (PC) are of increasing importance because this extracellular pathogen is a frequent source of severe pneumonia in patients with acquired immunodeficiency syndrome (AIDS) and is a leading cause of mortality in these patients. Immunoelectron microscopic localization of antigenic sites on the surface of PC would improve the understanding of these sites and their role in pathenogenisis of the disease and response to chemotherapy. The purpose of this study was to develop a methodology for visualizing immunoreactive sites on PC with transmission electron microscopy (TEM) using immunogold labeled probes.Trophozoites of PC were added to spinner flask cultures and allowed to grow for 7 days, then aliquots of tissue culture fluid were centrifuged at 12,000 RPM for 30 sec. Pellets of organisims were fixed in either 1% glutaraldehyde, 0.1% glutaraldehyde-4% paraformaldehyde, or 4% paraformaldehyde for 4h. All fixatives were buffered with 0.1M Na cacodylate and the pH adjusted to 7.1. After fixation the pellets were rinsed in 0.1M Na cacodylate (3X), dehydrated with ethanol, and immersed in a 1:1 mixture of 95% ethanol and LR White resin.

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