Daratumumab infusion reaction rates pre- and post-addition of montelukast to pre-medications

Daratumumab, a CD38-directed monoclonal antibody indicated for multiple myeloma treatment in adult patients, is associated with a high incidence of infusion-related reactions (IRRs). Due to CD38 receptor presence in the lungs, many reactions present similarly to asthma or allergic rhinitis. Montelukast, a leukotriene receptor antagonist, has been hypothesized to reduce daratumumab IRRs due to its efficacy in treating allergic rhinitis and asthma and the presence of leukotriene receptors in the lungs. Recently published data reported daratumumab can be safely administered via rapid rate protocol that reduces infusion time from 195 min to 90 min after completion of two doses. This retrospective, observational cohort study examined 73 patients who received daratumumab in the outpatient setting between December 2015 and April 2020. Patients were included if they were 18 years or older, had an International Classification of Disease (ICD)-10 diagnosis code for multiple myeloma, and received daratumumab intravenously. The primary outcome was a comparison of IRRs between those who did and did not receive montelukast. Secondary outcomes included IRR symptoms, rescue medications utilized for IRRs, and rapid rate administration outcomes. Montelukast use was associated with a lower rate of IRRs (44.4% vs. 65.2%, p = 0.044). Pulmonary IRR symptoms were more common in those who did not receive montelukast. Rapid rate administration of daratumumab did not lead to any IRRs. Adding montelukast as a pre-medication for daratumumab infusions led to a reduction in IRRs, and rapid rate administration was found to be safe after completion of two full doses of daratumumab.

Editorial to Special Issue Molecular Biology of Selenium in Health and Disease

The selenium field expanded at a rapid rate for about 45 years, from the mid-1970’s until about 2015 (see [...]

Future of Work and Its Implication on Employee Well-Being in the 4IR Era

Capitalist corporations seek ever-new opportunities for trade and gain. As competition intensifies within markets, profit-seeking corporations innovate and diversify their products in an unceasing pursuit of new market niches. The incessant changes and unpredictable nature of capitalism often leads to insecurity regarding job loss. Job insecurity has been empirically proven to have negative effects on individuals and organisations. It associates to reduced job satisfaction and decreased mental health. A longitudinal Swedish study showed an indirect effect of trust on job satisfaction and mental health of employees. The advent of AIs, humanoids, robotics, and digitization present reason for employees to worry about the future of their work. A recent study conducted by the McKinsey Global Institute reports that by 2030, a least 14% of employees globally could need changing their careers as a result of the rapid rate of digitization, robotics, and advancement in artificial intelligence disruptions in the world of work.

LGBTQIA+ Students

Structural changes have occurred at a rapid rate in the U.S. concerning LGBTQIA+ (lesbian, gay, bisexual, transgender, queer/questioning, intersex, and ally/asexual) rights and lived experiences. However, in K-12 education LGBTQIA+ students continue to face challenges and obstacles not faced by their heterosexual, cisgender peers. Using heteronormativity as its underpinning, this chapter will highlight some of the challenges encountered by LGBTQIA+ students, provide a background to understand the current state of educational practices and policies, and provide recommendations for teachers, administrators, students, and communities to help reduce the trauma endured by many LGBTQIA+ students.

Exacerbation of COVID 19 in Hypertensive Patients ( A review)

Since its discovery in December 2019, corona virus was outbreak worldwide with very rapid rate, so it described by WHO as pandemic. It associated with severe acute respiratory distress syndrome, and can enter to cells through Angiotensin Converting Enzyme 2 (ACE 2) receptor which play an important role as regulator for blood pressure. Hypertension is a potential risk factor for sever acute respiratory syndrome COVID-19, and associated with high mortality rate as shown in many epidemiological studies. Moreover, specific antihypertensive medications that infected patients were receiving are not known; only data about renin-angiotensin-aldosterone system (RAAS) are available.

Future Work: Exploring the Future of Work Spaces in the Context of Wellington

<p>This research analyses the forces that have led to the design of contemporary offices, examining how these forces are likely to change; with the goal of exploring what the future of workspaces might be. Digital technologies such as artificial intelligence are changing the world of work at a rapid rate, threatening to greatly increase effects of automation. Social changes in the way people work are also taking place, seen in the recent explosion in coworking. This gives rise to the question of what the implications of this are on the design of workspaces. This research uses the local context of Wellington as a vehicle to explore what the future of workspaces could be for the city, as well as wider New Zealand. A process of design led research is utilised, as the topic of work in general is vast, encompassing many different areas. This research also reviews how other designers and architects are responding to current workplace design issues, utilising these different approaches in the iterative design phase. The implications of this research relate directly to the city of Wellington, giving an idea of what the future of the office could be. The broad nature of the initial investigation also allows some conclusions to be applied internationally, as work in general is greatly examined.</p>

Future Work: Exploring the Future of Work Spaces in the Context of Wellington

<p>This research analyses the forces that have led to the design of contemporary offices, examining how these forces are likely to change; with the goal of exploring what the future of workspaces might be. Digital technologies such as artificial intelligence are changing the world of work at a rapid rate, threatening to greatly increase effects of automation. Social changes in the way people work are also taking place, seen in the recent explosion in coworking. This gives rise to the question of what the implications of this are on the design of workspaces. This research uses the local context of Wellington as a vehicle to explore what the future of workspaces could be for the city, as well as wider New Zealand. A process of design led research is utilised, as the topic of work in general is vast, encompassing many different areas. This research also reviews how other designers and architects are responding to current workplace design issues, utilising these different approaches in the iterative design phase. The implications of this research relate directly to the city of Wellington, giving an idea of what the future of the office could be. The broad nature of the initial investigation also allows some conclusions to be applied internationally, as work in general is greatly examined.</p>

A Deep Learning-Based Embedding Framework for Object Detection and Recognition in Underwater Marine Organisms

The detection of marine organisms is an important part of the intelligent strategy in marine ranch, which requires an underwater robot to detect the marine organism quickly and accurately in the complex ocean environment. Based on the latest deep learning arithmetic, this paper put forward to find the marine organism in a picture or video to construct a real-time objective invention system for marine organisms. The neural network arithmetic： YOLOv4 was employed to extract the deep features of marine organisms, implementing the accurate detection and size detection of different fish can use arithmetic for evaluation in fisheries. Furthermore, improving the architecture of the backbone and the neck connection is called YOLOv4-embedding. As a result, compared with other object detection arithmetic, YOLOv4-embedding object detection arithmetic was better at detection accuracy--higher detection confidence and higher detection ratio than other one-stage object detection arithmetic, EfficientDet-D3 example. The consequence demonstrates that the suggested instrument could implement the rapid invention of different varieties in marine organisms. Compared to the YOLOv4, the mAP 75 of the YOLOv4-embedding achieves an improvement of 2.92% for the marine organism dataset at a rapid rate of ~51 FPS on RTX 3090, 60.8% AP 50 for the MS COCO dataset.

A. D. Kaplan. First aid station in industrial plants. V. A. Obukh Institute for the Study of Occupational Diseases. Moscow, 1928 Publishing house of the Moszdravotdel

With the present rapid rate of growth of the industrialization of the country and the reconstruction of the socialist economy with its huge factories, factories, state and collective farms under construction, the question of first aid points becomes urgent. The appearance of this brochure in print should be hailed as the first experience of analyzing the problem of a first aid station in production from an organizational and surgical point of view. The author raises in detail and broadly the question of the approach of the attending physician to production, of the structure of the first aid station for the successful treatment of injuries and its prevention. Concerning the organizational form of the item, the author believes that this institution should not have medical functions, but only the provision of first aid, and should be organizationally individualized according to the characteristics of the injury rate of this enterprise. Due to the fact that it is not possible to get a sufficiently qualified specialist for such a point - a doctor, the standardization of first aid should be carefully developed: typification of stopping bleeding, handling a wound, burn, fracture, typing of dressings, etc. In addition, the responsibilities of the point should be immediate transportation of the victim to the nearest medical institution.

Opinion: revisiting the means to select and transmit of the AAC model

PurposeThis paper, a theoretical article, aims to revisit the augmentative and alternative communication (AAC) communication model and its transmission processes and interface as proposed by Lloyd, Quist and Windsor in 1990. More specifically, the focus of this paper is on the classifications of the SELECT (i.e. the means to select symbols) and TRANS (i.e. the means to transmit messages) components of the AAC transmission processes and interface.Design/methodology/approachThe field of AAC is evolving at a rapid rate. As the field continues to evolve in terms of its clinical, social, research and theoretical underpinnings, it is incumbent upon academics and practitioners in AAC to be cognizant of terminological and theoretical changes that may be needed to keep pace with the evolution of the field.FindingsThe authors welcome feedback from academics and clinicians with the hope that a more thorough discussion will lead stakeholders to more accurate and descriptive terminology related to the means to select and transmit components of the AAC model transmission processes.Originality/valueThe goal of this article was to suggest that the aided versus unaided classification continue to be used to classify the means to select but a new taxonomy be adopted for the means to transmit, thereby eliminating the use of the terms high and low technology. Terminology developed to describe TRANS should be unambiguous, include both expressive and receptive communication and be clinically relevant. In the opinion of the authors, the proposed taxonomy meets all three of these criteria.