A Case of Synchronous Double Lung Cancer with Tumor-to-tumor Metastasis, Namely with Small Cell Carcinoma Metastasizing to Squamous Cell Carcinoma

Introduction. Lung cancer is one of the most common malignant neoplasms, as well as the most common cause of death cancer. Most lung cancers are squamous cell carcinomas, small cell carcinomas or adenocarcinomas. Objective. Examining changes in trends of lung cancer incidence in Montenegro by histological type during a 15-year period, from 1997 to 2011. Methods. During the study period, histopathological confirmation was obtained for all primary lung cancer cases in the only hospital for lung diseases in the country. Based on the data from medical records, patients were classified by time period, sex, age groups and smoking history. Descriptive method was used. Results. Ratio between incidences of adenocarcinoma and squamous cell carcinoma changes in males, with a significant increase in the incidence rate of adenocarcinoma and drop in the rate of squamous cell carcinoma (p<0.001). In addition, statistically significant (p<0.05) decrease in the incidence of NSCLC (non-small cell lung cancer) and an increase in the incidence of SCLC (small cell lung cancer) was found. A statistically significant increase in linear trend in the incidence of small cell carcinoma was noted in females (p<0.005). Conclusion. Incidence rates of adenocarcinoma and small cell carcinoma have increased during the study period.

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Identification of potential serum biomarkers for simultaneously classifying lung adenocarcinoma, squamous cell carcinoma and small cell carcinoma

Cancer Biomarkers ◽

10.3233/cbm-201440 ◽

2020 ◽

pp. 1-12

Author(s):

Jiangqing Yu ◽

Fen Du ◽

Liping Yang ◽

Ling Chen ◽

Yuanxiang He ◽

...

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Small Cell ◽

Serum Biomarkers ◽

Stepwise Discriminant Analysis ◽

Mlp Model

BACKGROUND: Histological subtypes of lung cancer are crucial for making treatment decisions. However, multi-subtype classifications including adenocarcinoma (AC), squamous cell carcinoma (SqCC) and small cell carcinoma (SCLC) were rare in the previous studies. This study aimed at identifying and screening potential serum biomarkers for the simultaneous classification of AC, SqCC and SCLC. PATIENTS AND METHODS: A total of 143 serum samples of AC, SqCC and SCLC were analyzed by 1HNMR and UPLC-MS/MS. The stepwise discriminant analysis (DA) and multilayer perceptronMLPwere employed to screen the most efficient combinations of markers for classification. RESULTS: The results of non-targeted metabolomics analysis showed that the changes of metabolites of choline, lipid or amino acid might contribute to the classification of lung cancer subtypes. 17 metabolites in those pathways were further quantified by UPLC-MS/MS. DA screened out that serum xanthine, S-Adenosyl methionine (SAM), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCC) contributed significantly to the classification of AC, SqCC and SCLC. The average accuracy of 92.3% and the area under the receiver operating characteristic curve of 0.97 would be achieved by MLP model when a combination of those five variables as input parameters. CONCLUSION: Our findings suggested that metabolomics was helpful in screening potential serum markers for lung cancer classification. The MLP model established can be used for the simultaneous diagnosis of AC, SqCC and SCLC with high accuracy, which is worthy of further study.

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Surgical Resection for a Second Primary Lung Cancer Originating Close to the Initial Surgical Margin for Lung Squamous Cell Carcinoma

Case Reports in Surgery ◽

10.1155/2015/462193 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5

Author(s):

Seijiro Sato ◽

Terumoto Koike ◽

Takehisa Hashimoto ◽

Masanori Tsuchida

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Surgical Resection ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Surgical Margin ◽

Lung Squamous Cell Carcinoma ◽

Small Cell ◽

Second Primary

Few reports have described surgical resection for second primary lung cancers originating close to the initial surgical margin for lung cancer. A 64-year-old man had undergone left segmentectomy with lymph node dissection for small peripheral squamous cell lung cancer using video-assisted thoracic surgery, with pathology confirming a small tumor 12 mm in diameter identified about 3 cm from the surgical margin. Eighteen months after initial surgery, computed tomography revealed a 30 mm pulmonary nodule close to the initial surgical margin in the residual left upper lobe and the serum level of carcinoembryonic antigen was found to be increased. Local recurrence on the staple-line of the surgical margin was suspected, and completion left upper lobectomy was performed. Histological examination identified not only a squamous cell carcinoma component but also a small cell carcinoma component. The immunohistochemical staining pattern of the second tumor differed from that of the initial resected lung squamous cell carcinoma. The final pathological diagnosis was a second primary tumor with mixed small cell carcinoma and squamous cell carcinoma histology.

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Single primary lung cancer consisting of three cancer cell types (small cell carcinoma, adenocarcinoma, and squamous cell carcinoma) in which each had metastasized to different lymph nodes

The Japanese Journal of Thoracic and Cardiovascular Surgery ◽

10.1007/bf03032290 ◽

2002 ◽

Vol 50 (5) ◽

pp. 216-219 ◽

Cited By ~ 3

Author(s):

Hiroo Shikata ◽

Yoshimichi Ueda ◽

Shuji Tsuchishima ◽

Toshimichi Nonaka ◽

Yoh Watanabe ◽

...

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Cancer Cell ◽

Squamous Cell ◽

Primary Lung Cancer ◽

Cell Types ◽

Small Cell

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Lung Cancer with a Small Cell Carcinoma Component Diagnosed from Pleural Effusion and a Squamous Cell Carcinoma Component Diagnosed from the Tumor

Internal Medicine ◽

10.2169/internalmedicine.1200-18 ◽

2018 ◽

Vol 57 (23) ◽

pp. 3419-3422

Author(s):

Yoshiaki Zaizen ◽

Takaaki Tokito ◽

Ken Masuda ◽

Koichi Azuma ◽

Yoshiki Naito ◽

...

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Pleural Effusion ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Small Cell

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Human papillomavirus‐associated small cell carcinoma with synchronous squamous cell carcinoma in the nasopharynx: Report of a rare case

Cytopathology ◽

10.1111/cyt.12952 ◽

2020 ◽

Author(s):

Weihong Ma ◽

Guy Betts ◽

Michael Dykes ◽

Dominic St Leger ◽

Alexandra Sargent ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Rare Case ◽

Small Cell

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A re-evaluation of squamous cell carcinoma antigen (SCC) as a serum marker for non-small cell lung cancer

Medical Oncology ◽

10.1007/s12032-007-9021-3 ◽

2007 ◽

Vol 25 (2) ◽

pp. 187-189 ◽

Cited By ~ 11

Author(s):

Katsunori Kagohashi ◽

Hiroaki Satoh ◽

Hiroichi Ishikawa ◽

Morio Ohtsuka ◽

Kiyohisa Sekizawa

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Small Cell Lung Cancer ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cell Lung Cancer ◽

Serum Marker ◽

Small Cell ◽

Squamous Cell Carcinoma Antigen ◽

Small Cell Lung

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Epidemiologic trends in lung cancer over two decades in Northern Greece: an analysis of bronchoscopic data

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2009.346 ◽

2016 ◽

Vol 71 (4) ◽

Cited By ~ 1

Author(s):

T. Kontakiotis ◽

N. Manolakoglou ◽

F. Zoglopitis ◽

D. Iakovidis ◽

L. Sacas ◽

...

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Small Cell Lung Cancer ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Northern Greece ◽

Female Ratio

Background and Aim. The relative frequency of histological subtypes of lung cancer in Europe has changed dramatically during the 20th century. The aim of this study was to explore the changing epidemiology of lung cancer in Northern Greece over the last two decades. Methods. From the extensive database of the Bronchoscopy Unit of the G. Papanicolaou General Hospital, Thessaloniki, Greece, we identified all patients with a histologic and/or cytologic report positive for lung cancer over two consecutive decades. Results. Between 1/1/1986 and 31/12/2005 we identified 9981 patients with specimens positive for lung cancer. A significant increase in mean patient age was observed during the second decade (64.8±9.4 vs. 62.1±8.9, p=0.001). Men developed lung cancer ten times more often than women. The predominant histological type was squamous cell cancer in males (4203 cases, 45.7%) and adenocarcinoma (418 cases, 52.6%) in females. The number of lung cancer cases was significantly higher during the second decade compared to the first decade (5766 cases [57.8%] vs. 4215 cases [42.2%], respectively, p<0.001). There was a significant decrease in the percentage of squamous cell carcinoma in males in the second decade (2317 cases [44.1%] vs. 1886 cases [48.0%], p<0.001), and an increase in adenocarcinoma (1021 cases [19.4%] vs. 609 [11.6%], p<0.001). In females, the relative incidence of adenocarcinoma was decreased and that of squamous cell carcinoma was increased, but not significantly. There was no obvious change in the incidence of small cell lung cancer. Neoplastic lesions were most often located in the upper lobes. Conclusion. The number of lung cancer cases has increased in the last decade. Squamous lung cancer appears to be decreasing in men and increasing in women. Adenocarcinoma appears to be increasing in men and decreasing in women. There appears to be no change in small cell lung cancer. During the second decade there has been a significant decrease in the male: female ratio.

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