Association of MTHFR C677T, MTHFR A1298C and MTRR A66G Polymorphisms with Birth Defects in Southern China

Minmin Jiang; Shengwen Huang; Jun Yuan; Xingwei Ma; Xiaoli Wu; Zhaozhen Zhuo; Lingyan Ren; Qian Jin

doi:10.2485/jhtb.30.297

Association of MTHFR C677T, MTHFR A1298C and MTRR A66G Polymorphisms with Birth Defects in Southern China

Journal of Hard Tissue Biology ◽

10.2485/jhtb.30.297 ◽

2021 ◽

Vol 30 (3) ◽

pp. 297-302

Author(s):

Minmin Jiang ◽

Shengwen Huang ◽

Jun Yuan ◽

Xingwei Ma ◽

Xiaoli Wu ◽

...

Keyword(s):

Birth Defects ◽

Southern China

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Folic acid supplementation and risk for foetal abdominal wall defects in China: Results from a large population-based intervention cohort study

British Journal Of Nutrition ◽

10.1017/s0007114521000337 ◽

2021 ◽

pp. 1-20

Author(s):

Jufen Liu ◽

Zhiwen Li ◽

Rongwei Ye ◽

Aiguo Ren ◽

Jianmeng Liu

Keyword(s):

Cohort Study ◽

Folic Acid ◽

Abdominal Wall ◽

Birth Defects ◽

Southern China ◽

Large Population ◽

Northern China ◽

Population Based ◽

Abdominal Wall Defects ◽

Birth Prevalence

Abstract Folic acid (FA) can reduce the risk for selected birth defects other than neural tube defects (NTDs). We examined whether FA has preventive effects against foetal abdominal wall defects (AWDs) in a unique intervention cohort in China. Birth outcomes of 247 831 singleton births from a population-based cohort study with detailed preconceptional FA intake information were collected in China in 1993-1996. Information on births at 20 complete gestational weeks, including live births, stillbirths, and pregnancy terminations, and all structural birth defects regardless of gestational week was recorded. The birth prevalence of omphalocele, gastroschisis, and total foetal AWDs was classified by maternal FA supplementation. The prevalence of total AWDs was 4.30 per 10 000 births among women who took FA compared to 13.46 per 10 000 births among those who did not take FA in northern China and 6.28 and 5.18 per 10 000 births, respectively, in southern China. The prevalence of omphalocele was 0.54 per 10 000 births among women who took FA compared to 3.74 per 10 000 births among those who did not take FA in northern China and 1.79 and 1.44 per 10 000 births, respectively, in southern China. FA supplementation significantly prevented total AWDs in multivariate analysis (relative risk=0.26, 95% confidence interval: 0.11-0.61) in northern China, although no preventive effect of FA on AWDs was observed in southern Chin. FA supplementation successfully reduced the prevalence of AWDs in northern China.

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