Folic acid supplementation and risk for foetal abdominal wall defects in China: Results from a large population-based intervention cohort study

2021 ◽  
pp. 1-20
Author(s):  
Jufen Liu ◽  
Zhiwen Li ◽  
Rongwei Ye ◽  
Aiguo Ren ◽  
Jianmeng Liu
Keyword(s):  
Cohort Study ◽  
Folic Acid ◽  
Abdominal Wall ◽  
Birth Defects ◽  
Southern China ◽  
Large Population ◽  
Northern China ◽  
Population Based ◽  
Abdominal Wall Defects ◽  
Birth Prevalence

Abstract Folic acid (FA) can reduce the risk for selected birth defects other than neural tube defects (NTDs). We examined whether FA has preventive effects against foetal abdominal wall defects (AWDs) in a unique intervention cohort in China. Birth outcomes of 247 831 singleton births from a population-based cohort study with detailed preconceptional FA intake information were collected in China in 1993-1996. Information on births at 20 complete gestational weeks, including live births, stillbirths, and pregnancy terminations, and all structural birth defects regardless of gestational week was recorded. The birth prevalence of omphalocele, gastroschisis, and total foetal AWDs was classified by maternal FA supplementation. The prevalence of total AWDs was 4.30 per 10 000 births among women who took FA compared to 13.46 per 10 000 births among those who did not take FA in northern China and 6.28 and 5.18 per 10 000 births, respectively, in southern China. The prevalence of omphalocele was 0.54 per 10 000 births among women who took FA compared to 3.74 per 10 000 births among those who did not take FA in northern China and 1.79 and 1.44 per 10 000 births, respectively, in southern China. FA supplementation significantly prevented total AWDs in multivariate analysis (relative risk=0.26, 95% confidence interval: 0.11-0.61) in northern China, although no preventive effect of FA on AWDs was observed in southern Chin. FA supplementation successfully reduced the prevalence of AWDs in northern China.

scholarly journals Folic acid supplementation and risk for congenital limb reduction defects in China

2019 ◽  
Vol 48 (6) ◽  
pp. 2010-2017 ◽  
Author(s):  
Jufen Liu ◽  
Zhiwen Li ◽  
Rongwei Ye ◽  
Aiguo Ren ◽  
Jianmeng Liu
Keyword(s):  
Folic Acid ◽  
Southern China ◽  
Large Population ◽  
Northern China ◽  
Population Based ◽  
Folic Acid Supplementation ◽  
Live Births ◽  
Limb Reduction ◽  
Congenital Limb ◽  
Gestational Week

Abstract Background Folic acid (FA) supplementation prevents neural tube defects, but there are mixed results for its ability to prevent limb reduction defects. We examined whether a preventive effect of FA supplementation exists for congenital limb reduction defects in a large population in China. Methods Data from a large population-based cohort study in China were used to evaluate the effects of FA supplementation on birth defects. All births at 20 complete gestational weeks, including live births, stillbirths and pregnancy terminations, and all structural congenital anomalies, regardless of gestational week, were recorded. A total of 247 831 singleton live births delivered at gestational ages of 20–42 weeks to women from northern and southern China with full information on FA intake were included. Limb reduction defects were classified by subtype and maternal FA supplementation. Results The prevalence of limb reduction defects was 2.7 per 10 000 births among women who took FA compared with 9.7 per 10 000 births among those who did not take FA in northern China; the prevalence was 4.5 and 3.8 per 10 000 births, respectively, in southern China. In both unadjusted and adjusted analyses, the estimated relative risk for upper limb reduction defects [odds ratio (OR) = 0.17, 95% confidence interval (CI): 0.04, 0.63] and total limb reduction defects (OR = 0.24, 95% CI: 0.08, 0.70) in northern China, but not for lower limb reduction defects ,was significantly decreased in association with FA supplementation in northern China. There was no association between FA supplementation and either an increased or decreased risk for limb reduction defects in southern China. Conclusions FA supplementation successfully reduces the prevalence of limb reduction defects in northern China, whose population has low folate concentrations.

scholarly journals Population‐based birth defects data in the United States, 2012–2016: A focus on abdominal wall defects

2019 ◽  
Vol 111 (18) ◽  
pp. 1436-1447 ◽  
Author(s):  
Erin B. Stallings ◽  
Jennifer L. Isenburg ◽  
Tyiesha D. Short ◽  
Dominique Heinke ◽  
Russell S. Kirby ◽  
...  
Keyword(s):  
United States ◽  
Abdominal Wall ◽  
Birth Defects ◽  
The United States ◽  
Population Based ◽  
Abdominal Wall Defects

scholarly journals Folic acid supplementation and risk for congenital hydrocephalus in China

2021 ◽  
pp. 1-7
Author(s):  
Jufen Liu ◽  
Zhiwen Li ◽  
Rongwei Ye ◽  
Aiguo Ren ◽  
Jianmeng Liu
Keyword(s):  
Folic Acid ◽  
Large Population ◽  
Northern China ◽  
International Classification Of Diseases ◽  
Population Based ◽  
Folic Acid Supplementation ◽  
Congenital Hydrocephalus ◽  
Maternal Characteristics ◽  
The North ◽  
Classification Of Diseases

Abstract Objective: We examined whether folic acid (FA) supplementation prevented congenital hydrocephalus (CH) in more than 200 000 births in China. Design: A large population-based cohort study. Setting: All births at 20 complete gestational weeks, including live births, stillbirths and pregnancy terminations, and all structural birth defects regardless of gestational week were recorded. The prevalence of births with CH was classified by maternal characteristics and FA supplementation. CH was diagnosed in accordance with code 742.3 of the International Classification of Diseases, Ninth Revision, Clinical Modification, while non-neural tube defect (NTD) CH refers to CH without anencephaly (740), spina bifida (741) or encephalocele (742·0). Participants: A total of 247 831 pregnant women who delivered with known outcomes were included. Results: A total of 206 cases of CH (0·83 per 1000 births) and 170 cases of non-NTD CH (0·69 per 1000 births) were recorded in the study. The prevalence of CH and non-NTD CH was higher in women in the no supplementation group than those in the FA supplementation group (0·92 and 0·72 v. 0·75 and 0·65 per 1000 births, respectively). FA supplementation during the periconceptional period significantly prevented CH (OR = 0·29, 95 % CI 0·12, 0·69) and non-NTD CH (OR = 0·34, 95 % CI 0·12, 0·97) in northern China, especially in a high-compliance group (≥ 80 %). Conclusions: Periconceptional FA supplementation did not significantly prevent CH overall in the current study. However, in the north of China with common maternal folate insufficiency, there was some evidence.

Associations between Body Composition and Mortality: A Large Population-Based Cohort Study

2020 ◽  
Author(s):  
Fu-Rong Li ◽  
Pei-Liang Chen ◽  
Xin Cheng ◽  
Hai-Lian Yang ◽  
Wen-Fang Zhong ◽  
...  
Keyword(s):  
Body Composition ◽  
Cohort Study ◽  
Large Population ◽  
Population Based

scholarly journals Body-composition predictors of mortality in women aged ≥75 y: data from a large population-based cohort study with a 17-y follow-up

2014 ◽  
Vol 100 (5) ◽  
pp. 1352-1360 ◽  
Author(s):  
Yves Rolland ◽  
Adeline Gallini ◽  
Christelle Cristini ◽  
Anne-Marie Schott ◽  
Hubert Blain ◽  
...  
Keyword(s):  
Body Composition ◽  
Cohort Study ◽  
Large Population ◽  
Population Based ◽  
Predictors Of Mortality

scholarly journals P2-69 Metabolic syndrome and risk of brain tumour in a large population-based cohort study

2011 ◽  
Vol 65 (Suppl 1) ◽  
pp. A238-A239
Author(s):  
M. Edlinger ◽  
T. Bjorge ◽  
J. Manjer ◽  
P. Stattin ◽  
H. Ulmer
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Brain Tumour ◽  
Large Population ◽  
Population Based
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