Matched interface and boundary (MIB) method is introduced for free vibration analysis of irregular membranes. Two distinct schemes-on-interface and off-interface schemes are used to deal with the topological relations between edges of irregular domains and the Cartesian mesh lines. Different geometric shapes such as triangle and quadrilateral are dealt with by using MIB procedures. A number of examples are chosen to demonstrate the accuracy and convergence of MIB method. Numerical results show that MIB method is an efficient and highly accurate approach to solve free vibration problems of irregular membranes. This study further extends the application of MIB.