The study deals with experimental investigations into heat transfer flow boiling in rectangular, vertical and horizontal mini-channels. The dedicated measurement system was designed to observe flow boiling in the mini-channel. The main task of the system is to record images of two-phase flow with a high-speed video camera, which is equipped with the synchronous movement system. The data, in the form of the footage of two-phase flow structures, were subjected to the analysis with the scripts, developed for that purpose in the MathWorks Matlab 2010b environment. The scripts allowed the determination of void fraction for each pattern of two-phase flow structures observed, at various heat fluxes and various volume fluxes, for two spatial orientations of the mini-channel: vertical and horizontal.