scholarly journals Factors Determining the Intensive Care Need in Help Syndrome & AFLP in Pregnancy

2021 ◽  
Vol 6 (2) ◽  
pp. 1-5
Author(s):  
Aydin Atis Alev ◽  
Keyword(s):  
Intensive Care ◽  
Fatty Liver ◽  
Liver Enzyme ◽  
Elevated Liver Enzyme ◽  
Mortality And Morbidity ◽  
Factors Affecting ◽  
Acute Fatty Liver ◽  
In Pregnancy

To compare factors affecting mortality and morbidity in HELLP (Hemolysis, Elevated Liver Enzyme Levels, and Low Platelets) syndrome & AFLP (Acute fatty liver of pregnancy).

scholarly journals Fatal case of acute fatty liver of pregnancy

2020 ◽  
Vol 10 (1) ◽  
pp. 410
Author(s):  
Sarada Mamilla ◽  
Sandhya Rani ◽  
Gayathri . ◽  
Bhavana . ◽  
Ramya Bharghavi ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Fatty Liver ◽  
High Mortality ◽  
Disseminated Intravascular Coagulation ◽  
Fatal Case ◽  
Mortality And Morbidity ◽  
Intravascular Coagulation ◽  
Acute Fatty Liver ◽  
In Pregnancy

Acute fatty liver in pregnancy is a catstrophic condition with high mortality and morbidity. Delay in managing complications would result in fatality. We present a case of 22-year-old primi, who presented to us in labor with jaundice and later developed, disseminated intravascular coagulation, Vulval haematoma, reexploration, sepsis, ARDS and cardiac arrest and death.

scholarly journals Insufficienza renale acuta del postpartum: una diagnosi complessa?

2013 ◽  
Vol 25 (1) ◽  
pp. 26-31
Author(s):  
Giuseppe Gernone ◽  
Francesco Papagno ◽  
Vito Pepe ◽  
Francesco Soleti
Keyword(s):  
Fatty Liver ◽  
Plasma Exchange ◽  
Liver Enzyme ◽  
Elevated Liver Enzyme ◽  
Acute Fatty Liver

La diagnosi differenziale nei casi d'insufficienza renale acuta del postpartum associata ad anemia emolitica microangiopatica e trombocitopenia, include, tra le altre: pre-clampsia grave/eclampsia, grave eclampsia, la sindrome HELLP (Hemolysis, Elevated Liver enzyme, Low Platelet), la acute fatty liver of pregnancy (AFLP), la porpora trombotica trombocitopenica/sindrome emolitico-uremica associata alla gravidanza (TTP/aHUS), esordio acuto o flare di LES in gravidanza e la sindrome catastrofica da anticorpi antifosfolipidi (CAPS). Si tratta di condizioni potenzialmente pericolose per la vita data la presenza di disfunzione multiorgano. Il verificarsi di uno stato di ipercoagulabilità e la concentrazione decrescente di ADAMTS 13 in gravidanza e nel post-parto aumentano il rischio di sviluppare porpora trombotica trombocitopenica (TTP). Vi è però una notevole sovrapposizione riguardo la clinica ed i test di laboratorio tra queste condizioni, e quindi la diagnosi può essere un problema anche per clinici esperti. Tuttavia è importante stabilire un'accurata diagnosi poiché la gestione e le complicanze di tali sindromi possono essere differenti. Il caso presentato sottolinea la complessità connessa alla diagnosi differenziale dei quadri clinici che includono anemia emolitica microangiopatica e trombocitopenia connessi alla gravidanza ed il ruolo del plasma exchange nella loro gestione.

scholarly journals Acute Fatty Liver of Pregnancy and its Differentiation from Other Liver Diseases in Pregnancy

2015 ◽  
Vol 75 (08) ◽  
pp. 844-847 ◽  
Author(s):  
J. Maier ◽  
E. Schalinski ◽  
C. Häberlein ◽  
U. Gottschalk ◽  
L. Hellmeyer
Keyword(s):  
Fatty Liver ◽  
Liver Diseases ◽  
Acute Fatty Liver ◽  
In Pregnancy

scholarly journals Determining the Target Population That Would Most Benefit from Screening for Hepatic Fibrosis in a Primary Care Setting

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1605
Author(s):  
Su Hyun Park ◽  
Jong Hyun Lee ◽  
Dae Won Jun ◽  
Kyung A Kang ◽  
Ji Na Kim ◽  
...  
Keyword(s):  
Primary Care ◽  
Fatty Liver ◽  
Hepatic Fibrosis ◽  
Liver Enzyme ◽  
Elevated Liver Enzyme ◽  
Curve Analysis ◽  
Low Risk ◽  
Net Benefit ◽  
Diabetes Group ◽  
Decision Curve Analysis

Due to its high prevalence, screening for hepatic fibrosis in the low-risk population is called for action in the primary care clinic. However, current guidelines provide conflicting recommendations on populations to be screened. We aimed to identify the target populations that would most benefit from screening for hepatic fibrosis in clinical practice. This study examined 1288 subjects who underwent magnetic resonance elastography. The diagnostic performance of the Fibrosis-4 (FIB-4) index and NAFLD fibrosis score was compared in the following groups: (1) ultrasonography (USG)-diagnosed NAFLD, (2) elevated liver enzyme, (3) metabolic syndrome, (4) impaired fasting glucose, and (5) type 2 diabetes regardless of fatty liver. Decision curve analysis was performed to express the net benefit of groups over a range of probability thresholds (Pts). The diabetes group showed a better area under the receiver operating characteristic curve (AUROC: 0.69) compared with subjects in the USG-diagnosed NAFLD (AUROC: 0.57) and elevated liver enzyme (AUROC: 0.55) groups based on the FIB-4 index. In decision curve analysis, the diabetes group showed the highest net benefit for the detection of significant fibrosis across a wide range of Pts. Patients with diabetes, even in the absence of fatty liver, would be preferable for hepatic fibrosis screening in low-risk populations.

P371 Case series of acute fatty liver in pregnancy and literature review

2009 ◽  
Vol 107 ◽  
pp. S520-S520
Author(s):  
A. Uku ◽  
G. Mohiyiddeen ◽  
M. Raghavan ◽  
J. Wynn ◽  
T. Onon
Keyword(s):  
Literature Review ◽  
Fatty Liver ◽  
Case Series ◽  
Acute Fatty Liver ◽  
In Pregnancy

scholarly journals A Rare Disease Presenting Postpartum: Acute Fatty Liver of Pregnancy

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Sofía Córdoba-Vives ◽  
Patricia Pérez-Rodríguez ◽  
Astrid Marín-Delgado ◽  
Miguel Matus-Vargas ◽  
Adriana Arias-González
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Fatty Liver ◽  
Hepatic Dysfunction ◽  
Third Trimester ◽  
Fatal Disease ◽  
The Third ◽  
Emergency Cesarean ◽  
Acute Fatty Liver ◽  
High Index Of Suspicion

Acute fatty liver of pregnancy is a rare but highly fatal disease affecting women most frequently during the third trimester of pregnancy or in the postpartum period. It is considered a diagnosis of exclusion and requires a timely diagnosis to avoid maternal mortality. We present the case of a 33-year-old primigravida who required an emergency cesarean section due to fetal bradycardia. On postoperative day one, the patient was noted jaundiced, oliguric, and hypoglycemic. Laboratory tests revealed important hepatic dysfunction, coagulopathy, and renal failure. She was admitted to the Intensive Care Unit with the suspicion of acute fatty liver of pregnancy. Plasma exchange was started on postoperative day 5 with major clinical and laboratory improvement. A transjugular hepatic biopsy confirmed the diagnosis. The patient had satisfactory evolution and was discharged 15 days after delivery. Acute fatty liver of pregnancy is a highly morbid disease that needs a high index of suspicion to be diagnosed. Admission to an Intensive Care Unit to ensure maximum supportive care is mandatory in this disease.

Liver and endocrine diseases in pregnancy

2020 ◽  
pp. 295-305
Author(s):  
Catherine Williamson
Keyword(s):  
Fatty Liver ◽  
Rare Diseases ◽  
Adverse Outcomes ◽  
Reproductive Age ◽  
Endocrine Glands ◽  
Autoimmune Hypothyroidism ◽  
Endocrine Diseases ◽  
Acute Fatty Liver ◽  
Specific Disorders ◽  
In Pregnancy

Liver and endocrine diseases are sufficiently common in pregnancy that the majority of obstetricians will manage them regularly. They range from common disorders such as autoimmune hypothyroidism to rare diseases such as acute fatty liver of pregnancy. The liver and endocrine glands play important roles in homeostasis and metabolism, and abnormalities in their functioning can result in adverse outcomes for pregnant women and their children. This chapter describes the presentation and management of pregnancy-specific disorders of the liver and endocrine glands, and also focuses on the commoner disorders of these organs that can occur in women of reproductive age, and therefore which may also have an impact on pregnancy.

Antepartum Complications of Pregnancy

2018 ◽  
Author(s):  
Gaea Moore
Keyword(s):  
Cardiac Arrest ◽  
Fatty Liver ◽  
Multidisciplinary Care ◽  
Multidisciplinary Care Team ◽  
Perimortem Cesarean Section ◽  
Acute Fatty Liver ◽  
Pregnant State ◽  
Antepartum Complications ◽  
In Pregnancy

Pregnancy presents unique considerations and challenges to the critical care provider, including the physiologic adaptations to the pregnant state, recruitment and collaboration with a multidisciplinary care team, determination of fetal status, preparing for and managing cardiac arrest in pregnancy, and evaluation and management of diseases unique to pregnancy (including preeclampsia and acute fatty liver of pregnancy). This review contains 48 references, and 4 tables. Key words: acute fatty liver of pregnancy, maternal cardiac arrest, perimortem cesarean section, preeclampsia, pregnancy

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